2019
Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling
Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.Peer-Reviewed Original ResearchConceptsMyocardial blood flowSingle photon emissionBlood flowRecombinant TIMP-3Matrix metalloproteinasesR injuryTomography/Intracoronary deliveryMMP activationPost-myocardial infarction remodelingSubsequent left ventricular remodelingHybrid single-photon emissionDual-isotope single-photon emissionTomography/Computed Tomography ImagingLeft ventricular remodelingIschemia/reperfusionPost-MI remodelingPost-myocardial infarctionComputed tomography (CT) imagingIntracoronary infusionVentricular functionSaline groupVentricular remodelingNoninvasive evaluationTreatment groupsNoninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography
Boutagy NE, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MR, French BA, Annex BH, Carrasco N, Sinusas AJ. Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography. Circulation Cardiovascular Imaging 2019, 12: e009063. PMID: 31296047, PMCID: PMC6629470, DOI: 10.1161/circimaging.119.009063.Peer-Reviewed Original ResearchConceptsMicro-single photon emissionSingle photon emissionHindlimb ischemiaTomography/Tomography/Computed TomographyIschemic gastrocnemius muscleNIS inhibitor perchloratePeripheral artery diseaseSkeletal muscleUnilateral hindlimb ischemiaAdeno-Associated Virus Serotype 9Standardized uptake valueSodium/iodide symporterVivo quantificationVirus serotype 9Vivo validationNonischemic limbsArtery diseaseNonischemic muscleC57BL/6J miceMurine modelGastrocnemius muscleComputed tomographyIschemic conditionsRadiotracer uptakeMolecular Imaging Targets in Heart Failure and Left Ventricular Remodeling
Boutagy N, Feher A, Sikanderkhel S, Sinusas A. Molecular Imaging Targets in Heart Failure and Left Ventricular Remodeling. 2019, 405-435. DOI: 10.1002/9781118754467.ch13.ChaptersHeart failureManagement of HFMultimodality cardiovascular imagingMolecular imaging targetsMagnetic resonance imagingPositron emission tomographySingle photon emissionExtracellular matrix depositionCardiac injuryVentricle remodelingVentricular remodelingStandard clinical toolResonance imagingEmission tomographyClinical toolCompensatory mechanismsCardiac perfusionCardiovascular imagingNuclear imaging modalitiesImaging modalitiesImaging targetsPhoton emissionMatrix depositionNoninvasive measurementMolecular imagingMolecular Imaging of the Heart
Boutagy NE, Feher A, Alkhalil I, Umoh N, Sinusas AJ. Molecular Imaging of the Heart. 2019, 9: 477-533. PMID: 30873600, DOI: 10.1002/cphy.c180007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular diseaseRisk stratificationCardiovascular molecular imagingMultimodality cardiovascular imagingIschemic heart failureMolecular imagingMolecular imaging targetsPositron emission tomographySingle photon emissionNumerous cardiovascular diseasesClinical molecular imagingEjection fractionHeart failureMedical therapySystemic diseaseMyocardial infarctionPathophysiological changesCardiac functionEarly diagnosisDisease processCardiac arrhythmiasEmission tomographyCardiovascular imagingImaging strategiesPhoton emission
2017
Quantitative Assessment of Coronary Microvascular Function
Feher A, Sinusas AJ. Quantitative Assessment of Coronary Microvascular Function. Circulation Cardiovascular Imaging 2017, 10: e006427. PMID: 28794138, PMCID: PMC5678979, DOI: 10.1161/circimaging.117.006427.Peer-Reviewed Original ResearchMeSH KeywordsComputed Tomography AngiographyCoronary AngiographyCoronary CirculationEchocardiographyHeart DiseasesHumansMagnetic Resonance ImagingMicrocirculationMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsPrognosisReproducibility of ResultsTomography, Emission-Computed, Single-PhotonConceptsCoronary microvascular dysfunctionMyocardial blood flowMicrovascular dysfunctionBlood flowMyocardial perfusionCoronary microvascular impairmentCoronary microvascular functionEpicardial coronary arteriesNormal myocardial perfusionMyocardial contrast echocardiographyAbsolute myocardial blood flowImportant prognostic relevanceMagnetic resonance imagingPositron emission tomographySingle photon emissionMicrovascular impairmentMicrovascular functionMultiple imaging modalitiesPrognostic relevanceCoronary arteryCoronary flowCoronary perfusionContrast echocardiographyClinical valueFunctional microcirculation
2015
Myocardial perfusion pattern for stratification of ischemic mitral regurgitation response to percutaneous coronary intervention
Goyal P, Kim J, Feher A, L. C, Gurevich S, Veal DR, Szulc M, Wong FJ, Ratcliffe MB, Levine RA, Devereux RB, Weinsaft JW. Myocardial perfusion pattern for stratification of ischemic mitral regurgitation response to percutaneous coronary intervention. Coronary Artery Disease 2015, 26: 642-650. PMID: 26049923, PMCID: PMC4631658, DOI: 10.1097/mca.0000000000000271.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac-Gated Single-Photon Emission Computer-Assisted TomographyEchocardiographyExercise TestFemaleHeartHumansLogistic ModelsMaleMiddle AgedMitral Valve InsufficiencyMultivariate AnalysisMyocardial InfarctionMyocardial Perfusion ImagingPercutaneous Coronary InterventionRisk AssessmentStroke VolumeConceptsPercutaneous coronary interventionMyocardial perfusion imagingAdvanced mitral regurgitationMitral regurgitationMyocardial perfusionCoronary interventionPerfusion defectsLV volumesStress/rest myocardial perfusionLeft ventricular (LV) chamber dilationVentricular chamber dilationAbnormal myocardial perfusionMild mitral regurgitationPerfusion defect sizeIschemic mitral regurgitationMyocardial perfusion patternsRest myocardial perfusionSingle photon emissionTransthoracic echocardiographyChamber dilationPerfusion deficitsPerfusion patternsMR severityRest scorePerfusion differences