2024
Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation
Alashi A, Vermillion B, Callegari S, Burns R, Guo L, Moulton E, Guerrera N, Depino A, Papademetris X, Zeiss C, Thorn S, Liu C, Sinusas A. Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.087. DOI: 10.1093/ehjci/jeae142.087.Peer-Reviewed Original ResearchPeripheral arterial diseaseStandardized uptake valueHindlimb ischemia modelReactive hyperemiaSkeletal muscle perfusionPerfusion reserveCapillary densityPET imagingArtery diseaseNon-ischemicRubidium-82 positron emission tomographyType 2 muscle fibersRelevant pre-clinical modelIndicative of fibrosisManagement of peripheral arterial diseaseCapillary to muscle fiber ratioClinically relevant pre-clinical modelPre-clinical modelsMuscle perfusionFast myosinWeeks post-ligationRb-82 uptakeEvaluate treatment strategiesRabbit hindlimb ischemia modelPositron emission tomographyPAIN PROFILES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE: ROLE OF PSYCHOSOCIAL FACTORS AND FEMALE SEX
Alashi A, Hurtado C, Romain G, Callegari S, Jacque F, Sinusas A, Smolderen K. PAIN PROFILES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE: ROLE OF PSYCHOSOCIAL FACTORS AND FEMALE SEX. Journal Of The American College Of Cardiology 2024, 83: 2284. DOI: 10.1016/s0735-1097(24)04274-8.Peer-Reviewed Original Research
2023
The Potential Role of PET in the Management of Peripheral Artery Disease
Alashi A, Vermillion B, Sinusas A. The Potential Role of PET in the Management of Peripheral Artery Disease. Current Cardiology Reports 2023, 25: 831-839. PMID: 37314651, PMCID: PMC11542486, DOI: 10.1007/s11886-023-01904-8.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseLower extremitiesManagement of PADSetting of PADEarly detectionLarge vessel diseaseManagement of patientsNon-invasive testsPositron emission tomography (PET) imagingEmission Tomography ImagingNon-invasive toolVascular inflammationVessel diseaseMicrovascular perfusionRoutine screeningBlood flowClinical researchPatientsDiseaseTomography imagingPET imagingSkeletal musclePotential roleSummaryThe purpose
2020
Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy
Alashi A, Smedira NG, Hodges K, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Desai MY. Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy. Journal Of The American Heart Association 2020, 10: e016210. PMID: 33342243, PMCID: PMC7955478, DOI: 10.1161/jaha.120.016210.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresCardiomyopathy, HypertrophicDissectionEarly Medical InterventionEchocardiography, StressExercise TestFemaleHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsVentricular outflow tract gradientObstructive coronary artery diseaseBetter long-term survivalSurgical myectomyOutflow tract gradientObstructive hypertrophic cardiomyopathyCoronary artery diseaseLong-term survivalClass ITract gradientEarly surgeryArtery diseaseHypertrophic cardiomyopathyLeft ventricular outflow tract gradientAppropriate internal defibrillator dischargePrimary composite end pointBasal septal thicknessClass I indicationsPrimary composite eventsHypertrophic obstructive cardiomyopathyComposite end pointLong-term outcomesComposite eventsEarly referralObstructive cardiomyopathyLong-Term Outcomes of Patients With Mediastinal Radiation–Associated Coronary Artery Disease Undergoing Coronary Revascularization With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting
Dunn AN, Donnellan E, Johnston DR, Alashi A, Reed GW, Jellis C, Krishnaswamy A, Gillinov AM, Svensson LG, Ellis S, Griffin BP, Kapadia SR, Pettersson GB, Desai MY. Long-Term Outcomes of Patients With Mediastinal Radiation–Associated Coronary Artery Disease Undergoing Coronary Revascularization With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting. Circulation 2020, 142: 1399-1401. PMID: 33017210, DOI: 10.1161/circulationaha.120.046575.Peer-Reviewed Original Research
2019
P1951Serial left ventricular global longitudinal strain and mortality in patients with Takotsubo cardiomyopathy
Isaza N, Alashi A, Faulx J, Popovic Z, Menon V, Faulx M, Griffin B, Desai M. P1951Serial left ventricular global longitudinal strain and mortality in patients with Takotsubo cardiomyopathy. European Heart Journal 2019, 40: ehz748.0698. DOI: 10.1093/eurheartj/ehz748.0698.Peer-Reviewed Original ResearchLV ejection fractionLong-term mortalityLV-GLSGlobal longitudinal strainTransthoracic echocardiographyFunctional recoveryLV global longitudinal strainMultivariable Cox survival analysisLarge single-center studyObstructive coronary artery diseaseVentricular global longitudinal strainHigher long-term mortalityLongitudinal strainMean troponin ISingle-center studyCoronary artery diseaseKaplan-Meier curvesCox survival analysisMajority of casesAnginal symptomsPrimary endpointAngiographic evaluationApical ballooningArtery diseaseEjection fractionA novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
Oikonomou EK, Williams MC, Kotanidis CP, Desai MY, Marwan M, Antonopoulos AS, Thomas KE, Thomas S, Akoumianakis I, Fan LM, Kesavan S, Herdman L, Alashi A, Centeno EH, Lyasheva M, Griffin BP, Flamm SD, Shirodaria C, Sabharwal N, Kelion A, Dweck MR, Van Beek EJR, Deanfield J, Hopewell JC, Neubauer S, Channon KM, Achenbach S, Newby DE, Antoniades C. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European Heart Journal 2019, 40: 3529-3543. PMID: 31504423, PMCID: PMC6855141, DOI: 10.1093/eurheartj/ehz592.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCardiac risk predictionCoronary perivascular adipose tissueMajor adverse cardiac eventsCT angiographyRisk predictionHigh-risk plaque featuresPerivascular fat attenuation indexRadiomic featuresAdverse cardiac eventsConsecutive eligible participantsSCOT-HEART trialTraditional risk stratificationCoronary artery diseaseCoronary calcium scoreStandard coronary CT angiographyAcute myocardial infarctionCoronary inflammationCardiac eventsArtery diseaseCalcium scoreCardiac surgeryMACE prediction