Sreeganga Chandra, PhD

Professor of Neurology & Neuroscience

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Appointments

Fully Joint

Fully Joint

Contact Info

sreeganga.chandra@yale.edu

About

Titles

Professor of Neurology & Neuroscience

Biography

Sreeganga S. Chandra received her Ph.D. in Chemistry from Purdue University. In her postdoctoral research, she pursued her interest in neuronal cell biology and neurodegeneration in the lab of Thomas C. Südhof at UT Southwestern Medical Center at Dallas. She is currently an Associate Professor in the Departments of Neurology and Neuroscience.

Last Updated on February 11, 2025.

Appointments

Neurology
Professor
Fully Joint
Neurology
Neuroscience
Professor
Fully Joint
Neuroscience

Education & Training

PhD: Purdue University (1997)

Research

Overview

Role of the endolysosomal pathway in Parkinson's disease
Protein palmitoylation and neuronal ceroid lipofuscinosis
Identification of the physiological function of synucleins
Role of CSP alpha in synapse maintenance
Identification of novel synapse maintenance genes

Medical Research Interests

Neurodegenerative Diseases; Neurology; Neuronal Ceroid-Lipofuscinoses; Parkinson Disease; Receptors, Presynaptic; Synapses

ORCID
0000-0001-9035-1733
Chandra Lab
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Research at a Glance

Yale Co-Authors

Frequent collaborators of Sreeganga Chandra's published research.

TuKiet Lam, PhD, BS
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Hongyu Zhao, PhD
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Pramod Mistry, MBBS, PhD, MA, MD
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Chang Su
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David A. Hafler, MD, FANA, MSc
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Eduardo Martin-Lopez
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Publications

2026

Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis
Tieze S, Esqueda A, McAllister R, Lagator M, Yücel B, Sun E, Henke K, Lam T, Lockyer N, Gupta K, Chandra S. Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis. Acta Neuropathologica 2026, 151: 52. PMID: 42070169, DOI: 10.1007/s00401-026-03012-7.
Peer-Reviewed Original Research
MeSH Keywords

2025

Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies
Vidyadhara D, Bäckström D, Chakraborty R, Ruan J, Park J, Mistry P, Chandra S. Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies. Nature Communications 2025, 16: 8484. PMID: 41006254, PMCID: PMC12475166, DOI: 10.1038/s41467-025-63444-9.
Peer-Reviewed Original Research
MeSH Keywords

2024

Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997-eabo1997. PMID: 39475571, PMCID: PMC12372474, DOI: 10.1126/scitranslmed.abo1997.
Peer-Reviewed Original Research
MeSH Keywords
Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance
Wang N, Zhu B, Allnutt M, Grijalva R, Zhao H, Chandra S. Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320064121. PMID: 38833477, PMCID: PMC11181078, DOI: 10.1073/pnas.2320064121.
Peer-Reviewed Original Research
MeSH Keywords

2023

Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice
Cheng X, Tang Y, Vidyadhara D, Li B, Zimmerman M, Pak A, Nareddula S, Edens P, Chandra S, Chubykin A. Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice. IScience 2023, 26: 107842. PMID: 37766983, PMCID: PMC10520332, DOI: 10.1016/j.isci.2023.107842.
Peer-Reviewed Original Research
α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices
Vargas K, Colosi P, Girardi E, Park J, Harmon L, Chandra S. α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices. Journal Of Biological Chemistry 2023, 299: 105091. PMID: 37516240, PMCID: PMC10470054, DOI: 10.1016/j.jbc.2023.105091.
Peer-Reviewed Original Research
MeSH Keywords
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
Vidyadhara D, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam T, Sames D, Greene L, Sulzer D, Chandra S. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports 2023, 42: 112231. PMID: 36920906, PMCID: PMC10127800, DOI: 10.1016/j.celrep.2023.112231.
Peer-Reviewed Original Research
MeSH Keywords
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.
Peer-Reviewed Original Research
MeSH Keywords

2022

Pharmacological Mechanism of the Non-hallucinogenic 5‑HT2A Agonist Ariadne and Analogs
Cunningham M, Bock H, Serrano I, Bechand B, Vidyadhara D, Bonniwell E, Lankri D, Duggan P, Nazarova A, Cao A, Calkins M, Khirsariya P, Hwu C, Katritch V, Chandra S, McCorvy J, Sames D. Pharmacological Mechanism of the Non-hallucinogenic 5‑HT2A Agonist Ariadne and Analogs. ACS Chemical Neuroscience 2022, 14: 119-135. PMID: 36521179, PMCID: PMC10147382, DOI: 10.1021/acschemneuro.2c00597.
Peer-Reviewed Original Research
MeSH Keywords
Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain
Massaro Tieze S, Chandra S, Vidyadhara D. Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain. Journal Of Visualized Experiments 2022 DOI: 10.3791/64574-v.
Peer-Reviewed Original Research

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News & Links

Media

Many genes in the endolysosomal pathway are genetically linked to Parkinson's disease. We are investigating several genes that function in synaptic vesicle endocytosis.
Synuclein null synapses showing a deficit in HRP-cholera toxin positive vesicles (black vesicles). This experiment in synuclein null neurons supports a physiological role for alpha-synuclein in synaptic vesicle endocytosis.
Thomas Biederer, PhD & Sreeganga Chandra, PhD
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Contacts

Email

sreeganga.chandra@yale.edu

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