Chloe Hicks
she/her/hers
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Research
Publications
2026
Location-biased β-arrestin conformations direct GPCR signaling
Pham U, Chundi A, Stępniewski T, Darbha S, Eiger D, Gazula S, Gardner J, Hicks C, Selent J, Rajagopal S. Location-biased β-arrestin conformations direct GPCR signaling. Science Signaling 2026, 19: eady4950. PMID: 41875231, DOI: 10.1126/scisignal.ady4950.Peer-Reviewed Original Research
2024
GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization
Gardner J, Eiger D, Hicks C, Choi I, Pham U, Chundi A, Namjoshi O, Rajagopal S. GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization. Science Signaling 2024, 17: eadd9139-eadd9139. PMID: 38349966, PMCID: PMC10927030, DOI: 10.1126/scisignal.add9139.Peer-Reviewed Original Research
2023
Location bias: A “Hidden Variable” in GPCR pharmacology
Eiger D, Hicks C, Gardner J, Pham U, Rajagopal S. Location bias: A “Hidden Variable” in GPCR pharmacology. BioEssays 2023, 45: e2300123-e2300123. PMID: 37625014, PMCID: PMC11900906, DOI: 10.1002/bies.202300123.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPhosphorylation barcodes direct biased chemokine signaling at CXCR3
Eiger D, Smith J, Shi T, Stepniewski T, Tsai C, Honeycutt C, Boldizsar N, Gardner J, Nicora C, Moghieb A, Kawakami K, Choi I, Hicks C, Zheng K, Warman A, Alagesan P, Knape N, Huang O, Silverman J, Smith R, Inoue A, Selent J, Jacobs J, Rajagopal S. Phosphorylation barcodes direct biased chemokine signaling at CXCR3. Cell Chemical Biology 2023, 30: 362-382.e8. PMID: 37030291, PMCID: PMC10147449, DOI: 10.1016/j.chembiol.2023.03.006.Peer-Reviewed Original Research
2022
Location bias contributes to functionally selective responses of biased CXCR3 agonists
Eiger D, Boldizsar N, Honeycutt C, Gardner J, Kirchner S, Hicks C, Choi I, Pham U, Zheng K, Warman A, Smith J, Zhang J, Rajagopal S. Location bias contributes to functionally selective responses of biased CXCR3 agonists. Nature Communications 2022, 13: 5846. PMID: 36195635, PMCID: PMC9532441, DOI: 10.1038/s41467-022-33569-2.Peer-Reviewed Original ResearchGPCR systems pharmacology: a different perspective on the development of biased therapeutics
Eiger D, Pham U, Gardner J, Hicks C, Rajagopal S. GPCR systems pharmacology: a different perspective on the development of biased therapeutics. American Journal Of Physiology - Cell Physiology 2022, 322: c887-c895. PMID: 35196164, PMCID: PMC9037395, DOI: 10.1152/ajpcell.00449.2021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
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