Jeffery Kocsis, PhD
Professor of Neurology and of NeuroscienceDownloadHi-Res Photo
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Neurology
Primary
Neuroscience
Secondary
Additional Titles
Director , Postdoctoral Studies
Associate Director, Yale Center for Neuroscience and Regeneration Research
Senior Medical Research Career Scientist, Department of Veterans Affairs
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Appointments
Neurology
Primary
Neuroscience
Secondary
Additional Titles
Director , Postdoctoral Studies
Associate Director, Yale Center for Neuroscience and Regeneration Research
Senior Medical Research Career Scientist, Department of Veterans Affairs
Contact Info
Appointments
Neurology
Primary
Neuroscience
Secondary
Additional Titles
Director , Postdoctoral Studies
Associate Director, Yale Center for Neuroscience and Regeneration Research
Senior Medical Research Career Scientist, Department of Veterans Affairs
Contact Info
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Titles
Professor of Neurology and of Neuroscience
Director , Postdoctoral Studies; Associate Director, Yale Center for Neuroscience and Regeneration Research; Senior Medical Research Career Scientist, Department of Veterans Affairs
Appointments
Neurology
ProfessorPrimaryNeuroscience
ProfessorSecondary
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Education & Training
- PhD
- Wayne State University (1976)
Research
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Overview
Medical Research Interests
Cell Transplantation; Central Nervous System; Ion Channels; Nerve Regeneration; Neurology; Neurosciences; Spinal Cord; Spinal Cord Injuries; Veterans
ORCID
0000-0002-3780-7719
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jeffery Kocsis's published research.
Publications Timeline
A big-picture view of Jeffery Kocsis's research output by year.
Research Interests
Research topics Jeffery Kocsis is interested in exploring.
Stephen Waxman, MD, PhD
Masanori Sasaki, MD, PhD
Karen L Lankford, PhD
Osamu Honmou, MD, PhD
Stephen Strittmatter, MD, PhD, AB
Andrew Tan, PhD
142Publications
7,926Citations
Nerve Regeneration
Spinal Cord
Spinal Cord Injuries
Ion Channels
Cell Transplantation
Central Nervous System
Publications
2026
Mesenchymal stromal/stem cell-derived extracellular vesicles in brain disorders: mechanisms of repair and recovery
Nakazaki M, Lankford K, Ukai R, Hirota R, Oka S, Sasaki M, Kocsis J, Honmou O. Mesenchymal stromal/stem cell-derived extracellular vesicles in brain disorders: mechanisms of repair and recovery. Frontiers In Cellular Neuroscience 2026, 20: 1819046. PMID: 42179845, PMCID: PMC13193808, DOI: 10.3389/fncel.2026.1819046.Peer-Reviewed Original ResearchAltmetricConceptsMSC-sEVsCentral nervous systemMultiple sclerosisBlood-brain barrier restorationCargo to target cellsExtracellular vesiclesActivation of endogenous neural stem cellsPreservation of mitochondrial functionClinical validationPromotion of neurite outgrowthCytoskeletal remodelingMitophagy regulationTraumatic brain injuryEndogenous neural stem cellsCell-derived extracellular vesiclesGrowth signalsNeurological disordersMitochondrial functionAnti-inflammatory phenotypeBlood-brain barrierEffective regenerative therapiesCell-free approachCell-derived small extracellular vesiclesCell-free therapeuticsNeural stem cellsThe Pivotal Roles of Macrophages and Microglia in Mesenchymal Stromal/Stem Cell-Derived Small Extracellular Vesicle–Mediated Tissue Repair After Spinal Cord Injury
Nakazaki M, Lankford K, Yokoyama T, Ukai R, Hirota R, Oka S, Sasaki M, Kocsis J, Honmou O. The Pivotal Roles of Macrophages and Microglia in Mesenchymal Stromal/Stem Cell-Derived Small Extracellular Vesicle–Mediated Tissue Repair After Spinal Cord Injury. Frontiers In Bioscience-Landmark 2026, 31: 47612. PMID: 42052826, DOI: 10.31083/fbl47612.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBlood-spinal cord barrierSpinal cord injuryNOD-like receptor protein 3Myeloid cellsMSC-sEVsTherapeutic benefitInfiltration of peripheral immune cellsPericyte-endothelial interactionsCell-free therapeutic approachProduction of proinflammatory cytokinesProtein re-expressionSpinal cord injury pathophysiologyCord injuryExpression of anti-inflammatory mediatorsPeripheral immune cellsTransforming growth factor-betaActivated B cellsCD206+ macrophagesKappa-light-chain-enhancerRemoval of myelin debrisProgression of injuryM2-like phenotypeAnti-inflammatory mediatorsGrowth factor-betaReprogramming of macrophagesContinuous intravenous infusion of human mesenchymal stromal cell-derived small extracellular vesicles in spinal cord injured rat modulates extracellular matrix and has greater therapeutic efficacy than multiple single injections
Nakazaki M, Lankford K, Toyoshima M, Tanaka Y, Sumida T, Kocsis J. Continuous intravenous infusion of human mesenchymal stromal cell-derived small extracellular vesicles in spinal cord injured rat modulates extracellular matrix and has greater therapeutic efficacy than multiple single injections. Neurotherapeutics 2026, 23: e00892. PMID: 41894999, PMCID: PMC13054005, DOI: 10.1016/j.neurot.2026.e00892.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSpinal cord injured ratsContinuous intravenous infusionCell-derived small extracellular vesiclesContinuous infusionDaily injectionsOsmotic pumpTotal doseM2 macrophagesSmall extracellular vesiclesPBS-treated ratsDaily iv injectionsExtracellular vesiclesIn vitro uptakeMotor recoveryInjured ratsTreated ratsSCI ratsIV infusionTherapeutic efficacyExtracellular matrix depositionIV injectionTherapeutic outcomesMotor function recoveryFibrosis pathwaysInjury siteIntranasal administration of human mesenchymal stromal cell-derived small extracellular vesicles delays disease progression in the SOD1(G93A) mouse model
Hirota R, Lankford K, Nakazaki M, Toyoshima M, Kocsis J. Intranasal administration of human mesenchymal stromal cell-derived small extracellular vesicles delays disease progression in the SOD1(G93A) mouse model. Molecular Brain 2026, 19: 22. PMID: 41776544, PMCID: PMC13063686, DOI: 10.1186/s13041-026-01288-0.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIntranasal administrationMSC-sEV treatmentMSC-sEVsSmall extracellular vesiclesCentral nervous systemMouse modelAmyotrophic lateral sclerosisMesenchymal stem/stromal cellsPreservation of neurological functionNasal epithelial barrierMSC-derived small extracellular vesiclesAmyotrophic lateral sclerosis mouse modelCell-free therapeutic approachProgressive motor neuron lossVehicle-treated controlsLong-term administrationDelay disease progressionMotor neuron lossClinically Meaningful OutcomesTotal survival timeModels of injuryBlood-brain barrierDisease-modifying therapiesTransgenic mouse modelSurvival duration
2025
Mesenchymal stem cells reverse disease-specific abnormalities in nociceptive regions of the brain
Fukushi R, Sasaki M, Obara H, Kurihara K, Hirota R, Morita T, Teramoto A, Yamashita T, Tan A, Waxman S, Kocsis J, Honmou O. Mesenchymal stem cells reverse disease-specific abnormalities in nociceptive regions of the brain. Brain Communications 2025, 8: fcaf494. PMID: 41509715, PMCID: PMC12776362, DOI: 10.1093/braincomms/fcaf494.Peer-Reviewed Original ResearchAltmetricConceptsPeripheral nerve injury modelSystemic administration of mesenchymal stem cellsNerve injury modelAdministration of mesenchymal stem cellsMushroom-shaped spinesNeuropathic painSpinal cord injuryMesenchymal stem cellsSystemic administrationStem cellsDendritic spine morphologyInjury modelRemodeling of dendritic spinesDendritic spinesDorsal hornCord injuryAbnormal remodelingPeripheral nervesAbstract Neuropathic painNeuropathic pain presentationNeuropathic pain conditionsSpared nerve injuryBrain regionsSomatosensory nervous systemSpine morphologyTherapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy
Iizuka Y, Sasaki M, Terada K, Sakai T, Nagaoka Y, Fukumura S, Kocsis J, Tsugawa T, Honmou O. Therapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy. Pathophysiology 2025, 32: 19. PMID: 40407599, PMCID: PMC12101160, DOI: 10.3390/pathophysiology32020019.Peer-Reviewed Original ResearchCitationsConceptsMesenchymal stem cellsQuantitative real-time reverse-transcription PCRMSC infusionNephrotic syndromePAN injectionModulating oxidative stressIntravenously infused mesenchymal stem cellsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsInfused mesenchymal stem cellsOxidative stressEfficacy of mesenchymal stem cellsPodocyte structureSprague-Dawley ratsGFP-labeled mesenchymal stem cellsTherapeutic efficacy of mesenchymal stem cellsOxidative stress modulationPotential therapeutic approachReal-time reverse-transcription PCRCreatinine levelsReduce proteinuriaIntravenous infusionUrinary albuminTherapeutic efficacyIntravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury
Hirota R, Sasaki M, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury. Molecular Brain 2025, 18: 35. PMID: 40241097, PMCID: PMC12004759, DOI: 10.1186/s13041-025-01210-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsSpinal cord injuryIntravenous infusionMesenchymal stem cellsRubrospinal tractCircuit reorganizationInfused mesenchymal stem cellsCord injuryNeural circuit reorganizationNeuronal tracing techniquesSignal intensityInjury siteFunctional improvementSpontaneous recoveryStem cellsDescending tractsAxonal connectionsInjuryAxonal growthTractAxonal network
2024
Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury
Nakazaki M, Yokoyama T, Lankford K, Hirota R, Kocsis J, Honmou O. Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury. International Journal Of Molecular Sciences 2024, 25: 13460. PMID: 39769223, PMCID: PMC11677717, DOI: 10.3390/ijms252413460.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsMeSH Keywords and ConceptsConceptsBlood-spinal cord barrierBSCB repairMesenchymal stromal/stem cellsSpinal cord injuryMSC-EVsMesenchymal stromal/stem cell therapyBlood-spinal cord barrier integritySpinal cord homeostasisBlood-spinal cord barrier permeabilityCord injuryImpaired axonal regenerationTreating spinal cord injuryCell-free alternativeExtracellular vesiclesTight junction proteinsSpinal neural tissueBlood-brain barrierImprove patient outcomesAnti-inflammatory propertiesImmune cellsPreclinical studiesJunction proteinsSecreted extracellular vesiclesClinical trialsReduce inflammationMultiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia.
Yokoyama T, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Ukai R, Oka S, Kocsis J, Honmou O. Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia. Journal Of Neurosurgery 2024, 142: 684-692. PMID: 39454218, DOI: 10.3171/2024.6.jns241111.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInfusion of mesenchymal stem cellsMiddle cerebral artery occlusionMiddle cerebral artery occlusion inductionMesenchymal stem cellsCorpus callosumSystemic infusion of mesenchymal stem cellsMultiple infusionsAcute phaseMesenchymal stem cell infusionCerebral ischemiaStem cellsMultiple intravenous infusionsRat model of cerebral ischemiaHigh-dose infusionPermanent middle cerebral artery occlusionIschemic lesion volumeModels of cerebral ischemiaCC thicknessRandomized clinical trialsCerebral artery occlusionNeural tractsAcute cerebral strokeFunctional recovery outcomesMRI diffusion tensor imagingMSC-3Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series
Hirota R, Sasaki M, Iyama S, Kurihara K, Fukushi R, Obara H, Oshigiri T, Morita T, Nakazaki M, Namioka T, Namioka A, Onodera R, Kataoka-Sasaki Y, Oka S, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Okuma Y, Kondo R, Aichi R, Ohmatsu S, Kawashima N, Ito Y, Kobune M, Takada K, Ishiai S, Ogata T, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. Journal Of Clinical Medicine 2024, 13: 6072. PMID: 39458022, PMCID: PMC11509003, DOI: 10.3390/jcm13206072.Peer-Reviewed Original ResearchCitationsConceptsAmerican Spinal Injury Association Impairment ScaleSevere spinal cord injuryMesenchymal stem cell infusionAutologous mesenchymal stem cellsIntravenous infusionCase seriesMesenchymal stem cellsQuality of lifeAuto-serumSpinal cord injuryFunctional improvementChronic spinal cord injury patientsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsCord injurySpinal Cord Independence Measure IIIAmerican Spinal Injury Association Impairment Scale grades CSpinal cord injury patientsChronic SCI patientsClassification of Spinal Cord InjuryNeurological Classification of Spinal Cord InjurySignificant functional improvementAssociation Impairment ScaleInternational Standards for Neurological Classification of Spinal Cord Injury
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