Dustin Scheinost, PhD, BS
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
Featured Publications
Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences
Rodriguez R, Noble S, Camp C, Scheinost D. Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences. Nature Neuroscience 2025, 28: 2601-2611. PMID: 41184631, PMCID: PMC12641774, DOI: 10.1038/s41593-025-02099-7.Peer-Reviewed Original ResearchConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchBrain age prediction and deviations from normative trajectories in the neonatal connectome
Sun H, Mehta S, Khaitova M, Cheng B, Hao X, Spann M, Scheinost D. Brain age prediction and deviations from normative trajectories in the neonatal connectome. Nature Communications 2024, 15: 10251. PMID: 39592647, PMCID: PMC11599754, DOI: 10.1038/s41467-024-54657-5.Peer-Reviewed Original ResearchThe tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research
Noble S, Curtiss J, Pessoa L, Scheinost D. The tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research. Imaging Neuroscience 2024, 2: imag-2-00138. PMID: 40740614, PMCID: PMC12247580, DOI: 10.1162/imag_a_00138.Peer-Reviewed Original Research
2026
Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting
Samardzija A, Shen X, Luo W, Greene A, Mehta S, Tokoglu F, Arora J, Woods S, Katz R, Sanacora G, Srihari V, Scheinost D, Constable R. Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting. Nature Communications 2026 PMID: 42303975, DOI: 10.1038/s41467-026-73941-0.Peer-Reviewed Original ResearchNeuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson’s disease severity
Honhar P, Tinaz S, Ebrahimian Sadabad F, Dias M, Yang Y, Henry S, Hillmer A, Zakiniaeiz Y, Radhakrishnan R, Comley R, Zhang X, Hooker B, Zhang Y, Finnema S, Carson R, Scheinost D, Matuskey D. Neuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson’s disease severity. Npj Parkinson's Disease 2026 PMID: 42248873, DOI: 10.1038/s41531-026-01411-x.Peer-Reviewed Original ResearchExternal validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging
Rosenblatt M, Foster M, Adkinson B, Tejavibulya L, Khaitova M, Ye J, Sun H, Rodriguez R, Camp C, Chinta A, McCusker M, Han L, Fields C, Mehta S, Scheinost D. External validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging. Nature Methods 2026, 1-11. PMID: 42203860, DOI: 10.1038/s41592-026-03115-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsWhat effect sizes can we expect in functional neuroimaging?
Shearer H, Rosenblatt M, Ye J, Jiang R, Tejavibulya L, Foster M, Liang Q, Dadashkarimi J, Westwater M, Cheng I, Rolison M, Peterson H, Adkinson B, Mehta S, Camp C, Fischbach A, Cravo F, Meija A, Nichols T, Curtiss J, Scheinost D, Noble S. What effect sizes can we expect in functional neuroimaging? JoCN Forum 2026 DOI: 10.21428/8e6ba8ef.af9f794c.Peer-Reviewed Original ResearchThe metabolomic signatures mediate associations between physical frailty and metabolic dysfunction–associated steatotic liver disease
Jiang R, Rosenblatt M, Qi S, Calhoun V, Wang Q, Wang P, Wu J, Scheinost D, Sui J. The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction–associated steatotic liver disease. Science Advances 2026, 12: eaeg4939. PMID: 42127175, PMCID: PMC13170646, DOI: 10.1126/sciadv.aeg4939.Peer-Reviewed Original ResearchOptimizing functional connectivity scanning conditions for predicting autistic traits
Horien C, Mandino F, Greene A, Shen X, Powell K, Vernetti A, O’Connor D, Adkinson B, Tejavibulya L, McPartland J, Volkmar F, Chun M, Chawarska K, Lake E, Rosenberg M, Satterthwaite T, Scheinost D, Finn E, Constable R. Optimizing functional connectivity scanning conditions for predicting autistic traits. Nature Mental Health 2026, 4: 792-805. PMID: 42137910, PMCID: PMC13167459, DOI: 10.1038/s44220-026-00623-7.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Connectivity While Coming of Age
IRB ID2000028368RoleSub InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsGenderBothAge18 years - 25 yearsBrain Imaging Study of Emotion Regulation in Children
IRB ID2000031303RoleSub InvestigatorPrimary Completion Date11/30/2023Recruiting ParticipantsGenderBothAge5 years - 15 yearsStudying the Adult Brain
IRB ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsGenomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
IRB ID2000020449RoleSub InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsGenderBothAge8+ yearsTiny Beginnings, Big Impact: How Early Brain Communication Supports Social Development
IRB ID2000021541RoleSub InvestigatorPrimary Completion Date08/31/2023Recruiting ParticipantsGenderBothAgeUp to 1 year 9 months
News
News
- August 18, 2026
Why Brain Imaging Doesn’t Always Hold Up—and How Experts Say to Fix It
- April 15, 2026
Overlooked Brain Connections Hold Clues to Cognition and Mental Health
- January 13, 2026
More Than Just Fear: A New Profile of Post-traumatic Stress Disorder
- December 01, 2025
From the Journals
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Mailing Address
Bioimaging Sciences
300 cedar st
New Haven, CT 06520
United States