2017
Vitrectomy in the management of diabetic macular edema in treatment-naïve patients
Michalewska Z, Stewart MW, Landers MB, Bednarski M, Adelman RA, Nawrocki J. Vitrectomy in the management of diabetic macular edema in treatment-naïve patients. Canadian Journal Of Ophthalmology 2017, 53: 402-407. PMID: 30119796, DOI: 10.1016/j.jcjo.2017.10.011.Peer-Reviewed Original ResearchConceptsTreatment-naïve diabetic macular edemaDiabetic macular edemaCentral retinal thicknessPars plana vitrectomyMacular edemaVisual acuityPlana vitrectomyMean central retinal thicknessDuration of diabetesProspective randomized trialsTreatment-naïve patientsInitial visual acuityVisual acuity changesPrimary outcome measureEfficacy of vitrectomyElectronic medical recordsEarly vitrectomyIntravitreal bevacizumabFinal BCVAMean BCVAPrimary endpointRetinal thicknessConsecutive patientsRandomized trialsRetrospective study
2016
Aflibercept in diabetic macular edema: evaluating efficacy as a primary and secondary therapeutic option
Ashraf M, Souka A, Adelman R, Forster SH. Aflibercept in diabetic macular edema: evaluating efficacy as a primary and secondary therapeutic option. Eye 2016, 31: 342-345. PMID: 27813521, PMCID: PMC5306454, DOI: 10.1038/eye.2016.233.Peer-Reviewed Original ResearchAflibercept in diabetic macular edema: evaluating efficacy as a primary and secondary therapeutic option
Ashraf M, Souka A, Adelman R, Forster SH. Aflibercept in diabetic macular edema: evaluating efficacy as a primary and secondary therapeutic option. Eye 2016, 30: 1531-1541. PMID: 27564719, PMCID: PMC5177746, DOI: 10.1038/eye.2016.174.Peer-Reviewed Original ResearchConceptsDiabetic macular edemaMacular edemaLarge phase 3 trialsBetter baseline VAEfficacy of afliberceptRole of afliberceptSecondary therapeutic optionsPhase 3 trialProtocol TBaseline VABimonthly regimenNata protocolAnatomic outcomesTherapeutic optionsPoor visionTreatment strategiesPrimary drugAfliberceptDifferent dosesDoseRanibizumabRegimenEdemaPatientsRecent dataPredicting outcomes to anti-vascular endothelial growth factor (VEGF) therapy in diabetic macular oedema: a review of the literature
Ashraf M, Souka A, Adelman R. Predicting outcomes to anti-vascular endothelial growth factor (VEGF) therapy in diabetic macular oedema: a review of the literature. British Journal Of Ophthalmology 2016, 100: 1596. PMID: 27231313, DOI: 10.1136/bjophthalmol-2016-308388.Peer-Reviewed Original ResearchConceptsDiabetic macular edemaOptical coherence tomographyMacular edemaAnti-vascular endothelial growth factor therapyIntravitreal anti-vascular endothelial growth factorAnti-vascular endothelial growth factorEndothelial growth factor therapyFluorescein angiography findingsAnti-VEGF therapyAnti-VEGF agentsGrowth factor therapyCourse of treatmentCommon prognostic indicatorsEndothelial growth factorFactor therapyMost patientsVisual outcomeAngiography findingsChoroidal thicknessLarge RCTsTreatment regimenOCT parametersVisual acuityPrognostic indicatorDifferent RCTs
2015
Corrigendum to “Strategy for the Management of Diabetic Macular Edema: The European Vitreo‐Retinal Society Macular Edema Study”
Adelman RA, Parnes AJ, Michalewska Z, Parolini B, Boscher C, Ducournau D, Group E. Corrigendum to “Strategy for the Management of Diabetic Macular Edema: The European Vitreo‐Retinal Society Macular Edema Study”. BioMed Research International 2015, 2015: 694902. PMID: 26798639, PMCID: PMC4698543, DOI: 10.1155/2015/694902.Peer-Reviewed Original ResearchCorrigendum to “Strategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study”
Adelman RA, Parnes AJ, Bopp S, Othman I, Ducournau D, Group E. Corrigendum to “Strategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study”. BioMed Research International 2015, 2015: 694690. PMID: 26697492, PMCID: PMC4677158, DOI: 10.1155/2015/694690.Peer-Reviewed Original ResearchStrategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study
Adelman RA, Parnes AJ, Bopp S, Othman I, Ducournau D. Strategy for the Management of Macular Edema in Retinal Vein Occlusion: The European VitreoRetinal Society Macular Edema Study. BioMed Research International 2015, 2015: 870987. PMID: 25705695, PMCID: PMC4325227, DOI: 10.1155/2015/870987.Peer-Reviewed Original ResearchConceptsRetinal vein occlusionCentral retinal vein occlusionBranch retinal vein occlusionVein occlusionMacular edemaVisual acuityIntravitreal antivascular endothelial growth factor injectionsAntivascular endothelial growth factor injectionsCases of RVOEndothelial growth factor injectionsGrowth factor injectionsChoice of treatmentMulticenter collaborative studyEdema studyFactor injectionsNonsurgical treatmentNumber of treatmentsVEGF injectionPlana vitrectomyRVO casesILM peelingRetina specialistsVisual gainDiagnostic findingsVisual improvementStrategy for the Management of Diabetic Macular Edema: The European Vitreo‐Retinal Society Macular Edema Study
Adelman R, Parnes A, Michalewska Z, Parolini B, Boscher C, Ducournau D. Strategy for the Management of Diabetic Macular Edema: The European Vitreo‐Retinal Society Macular Edema Study. BioMed Research International 2015, 2015: 352487. PMID: 25695062, PMCID: PMC4324105, DOI: 10.1155/2015/352487.Peer-Reviewed Original ResearchConceptsDiabetic macular edemaMacular edemaVisual acuityVisual improvementBetter visual improvementMulticenter clinical studyPars plana vitrectomySignificant visual improvementEdema studyTriamcinolone monotherapyVEGF therapyVEGF injectionVision gainClinical findingsGrid laserPlana vitrectomyRetina specialistsClinical studiesDifferent therapiesClinical informationEdemaAcuityTherapyMean numberTreatmentRecent developments in laser treatment of diabetic retinopathy
Yun SH, Adelman RA. Recent developments in laser treatment of diabetic retinopathy. Middle East African Journal Of Ophthalmology 2015, 22: 157-163. PMID: 25949072, PMCID: PMC4411611, DOI: 10.4103/0974-9233.150633.Peer-Reviewed Original ResearchConceptsDiabetic retinopathyAntivascular endothelial growth factor therapyEndothelial growth factor therapyProliferative diabetic retinopathyGrowth factor therapyPattern scan laserDiabetic retinopathy treatmentLaser treatmentFactor therapyMacular edemaLaser photocoagulationRetinopathy treatmentLaser therapyRetinopathyScan laserTherapyTreatmentEdemaPhotocoagulationMainstay
2014
Aflibercept in the Treatment of Neovascular Age-Related Macular Degeneration in Previously Treated Patients
Hall LB, Zebardast N, Huang JJ, Adelman RA. Aflibercept in the Treatment of Neovascular Age-Related Macular Degeneration in Previously Treated Patients. Journal Of Ocular Pharmacology And Therapeutics 2014, 30: 346-352. PMID: 24552305, DOI: 10.1089/jop.2013.0188.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAntibodies, Monoclonal, HumanizedBevacizumabFemaleHumansIntravitreal InjectionsMacular DegenerationMaleRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsRetinaRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVascular Endothelial Growth Factor AVisual AcuityConceptsAge-related macular degenerationCentral macular thicknessAflibercept injectionsInitial visitMacular degenerationAnti-vascular endothelial growth factor treatmentNeovascular age-related macular degenerationEndothelial growth factor treatmentCentral macular edemaIntraocular pressure increaseSubset of patientsMain outcome measuresOptical coherence tomographyGrowth factor treatmentMacular thicknessNeovascular AgeOcular hypertensionSubmacular fluidVisual outcomeMacular edemaRetrospective studyVisual acuityOutcome measuresStudy populationPatients
2007
Ethambutol Neuroretinopathy
Vistamehr S, Walsh TJ, Adelman RA. Ethambutol Neuroretinopathy. Seminars In Ophthalmology 2007, 22: 141-146. PMID: 17763233, DOI: 10.1080/08820530701457134.Peer-Reviewed Original ResearchConceptsElectrophysiological findingsRetinal pigment epithelial changesAbnormal Arden ratioElectro-oculogram findingsFlame-shaped hemorrhagesPigment epithelial changesFull-field ERGAbnormal wave patternRetinal findingsElectroretinogram findingsMacular edemaClinical featuresEpithelial changesCase reportOcular toxicityPattern ERGArden ratioNeuroretinopathyVisual fieldToxic effectsFindingsEdemaHemorrhagePatientsEthambutol