2018
The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells
Rodríguez-Menéndez S, García M, Fernández B, Álvarez L, Fernández-Vega-Cueto A, Coca-Prados M, Pereiro R, González-Iglesias H. The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells. Nutrients 2018, 10: 1874. PMID: 30513827, PMCID: PMC6315569, DOI: 10.3390/nu10121874.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumOxidative stressRetinal pigment epithelial cellsOxidative damagePre-treated cellsInduces oxidative stressPigment epithelial cellsNon-treated cellsReactive oxygen intermediatesΜM of zincPigment epitheliumRPE cellsZn-MTProtective mechanismEpithelial cellsFree radical generatorMT levelsAAPH treatmentOxygen intermediates
2013
Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle
Gonzalez-Iglesias H, Alvarez L, García M, Petrash C, Sanz-Medel A, Coca-Prados M. Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle. Metallomics 2013, 6: 201-208. PMID: 24419560, DOI: 10.1039/c3mt00298e.Peer-Reviewed Original ResearchConceptsCellular zinc homeostasisOxidative damageAntioxidant functionMT genesMultiple isoformsReactive oxygen speciesPotential oxidative damageDe novo synthesisZinc homeostasisAntioxidant defense mechanismsMain regulatorDefense mechanismsNovo synthesisProtein expressionOxygen speciesExogenous zincZn7-MTMetallothioneinOxidative stressMT complexZinc releaseStoichiometric transitionsZinc-MTPro-inflammatory cytokinesLevels of metallothionein