2013
Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle
Gonzalez-Iglesias H, Alvarez L, García M, Petrash C, Sanz-Medel A, Coca-Prados M. Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle. Metallomics 2013, 6: 201-208. PMID: 24419560, DOI: 10.1039/c3mt00298e.Peer-Reviewed Original ResearchConceptsCellular zinc homeostasisOxidative damageAntioxidant functionMT genesMultiple isoformsReactive oxygen speciesPotential oxidative damageDe novo synthesisZinc homeostasisAntioxidant defense mechanismsMain regulatorDefense mechanismsNovo synthesisProtein expressionOxygen speciesExogenous zincZn7-MTMetallothioneinOxidative stressMT complexZinc releaseStoichiometric transitionsZinc-MTPro-inflammatory cytokinesLevels of metallothionein
2012
The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression QUANTITATIVE ANALYSIS OF MT-METAL LOAD IN EYE CELLS*
Alvarez L, Gonzalez-Iglesias H, Garcia M, Ghosh S, Sanz-Medel A, Coca-Prados M. The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression QUANTITATIVE ANALYSIS OF MT-METAL LOAD IN EYE CELLS*. Journal Of Biological Chemistry 2012, 287: 28456-28469. PMID: 22722935, PMCID: PMC3436589, DOI: 10.1074/jbc.m112.365015.Peer-Reviewed Original ResearchConceptsInflammatory eye diseaseRetinal ganglion cellsPresence of TNFαCorneal epithelial cell lineInflammatory cytokinesProinflammatory cytokinesEpithelial cell lineSynthesis of metallothioneinGanglion cellsEye diseaseLevels of metallothioneinCorneal tissueCombination of zincEndothelial cellsCytokinesMT1 isoformsIL1αEffect of zincGene expressionCadaver eyesConcentration of metallothioneinEye cellsMicroarray-based analysisZinc exposureMT isoforms