2019
Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1
Ribic A, Crair MC, Biederer T. Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1. Cell Reports 2019, 26: 381-393.e6. PMID: 30625321, PMCID: PMC6345548, DOI: 10.1016/j.celrep.2018.12.069.Peer-Reviewed Original ResearchConceptsCortical plasticityCell adhesion molecule-1Critical periodJuvenile-like plasticityAdhesion molecule-1Primary visual cortexVisual critical periodThalamocortical inputsCortical maturationCircuit maturationV1 plasticityParvalbumin interneuronsFeedforward inhibitionSynaptic cell adhesion molecule 1Cell-autonomous mechanismsBrief lossCortical responsesSynaptic lociMolecule-1Visual cortexSynaptic factorsInterneuronsSpecific knockdownAdulthoodEyes
2014
Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1
Ribic A, Liu X, Crair MC, Biederer T. Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. The Journal Of Comparative Neurology 2014, 522: 900-920. PMID: 23982969, PMCID: PMC3947154, DOI: 10.1002/cne.23452.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAnalysis of VarianceAnimalsAnimals, NewbornCell Adhesion Molecule-1Cell Adhesion MoleculesCo-Repressor ProteinsDNA-Binding ProteinsElectroretinographyFemaleGene Expression Regulation, DevelopmentalImmunoglobulinsMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ImmunoelectronNerve Tissue ProteinsPhosphoproteinsReceptors, Metabotropic GlutamateRetinaRetinal Rod Photoreceptor CellsSynapsesVesicular Glutamate Transport Protein 1ConceptsCell adhesion molecule-1Adhesion molecule-1Ribbon synapsesKO retinasSynaptic cell adhesion molecule 1Molecule-1Mouse photoreceptor ribbon synapsesInner retinal layersPhotoreceptor ribbon synapsesRod visual pathwayEarly postnatal stagesPlexiform layerKO micePhotoreceptor synapsesSynaptic organizationExcitatory synapsesQuantitative ultrastructural analysisRetinal layersKnockout miceOuter nuclearVisual pathwaySynapse developmentElectroretinogram recordingsPostnatal stagesAdhesion molecules
2013
Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus
Furman M, Xu HP, Crair MC. Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus. Journal Of Neurophysiology 2013, 110: 1441-1454. PMID: 23741047, PMCID: PMC3763158, DOI: 10.1152/jn.01066.2012.Peer-Reviewed Original ResearchConceptsSuperior colliculusRetinal wavesRetinal inputBrain slice preparationActivity-dependent competitionWT miceRetinofugal axonsSlice preparationSC neuronsTransgenic miceBrain regionsSynaptic strengthSynaptic developmentSynapse developmentMiceNeuronsEye openingFunctional developmentSynapsesColliculusMolecular mechanismsSpecific roleInstructive roleMorphological developmentAxons
2012
Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening
Furman M, Crair MC. Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening. Journal Of Neurophysiology 2012, 107: 3200-3216. PMID: 22402661, PMCID: PMC3774562, DOI: 10.1152/jn.00943.2011.Peer-Reviewed Original ResearchConceptsSuperior colliculusLateral superior colliculusMedial superior colliculusEye openingP6-7Synaptic strengthBinocular interactionEye-specific segregationPatch-clamp recordingsRetinocollicular synapsesIpsilateral eyeNeonatal miceSlice preparationSynaptic basisMonocular enucleationDendritic arborsSynapse maturationTarget neuronsRetinal axonsDendritic branchingRetinocollicular mapSynaptic connectivityPostsynaptic partnersBinocular competitionSynapse development
2010
The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina
Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N. The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina. Neuron 2010, 65: 503-515. PMID: 20188655, PMCID: PMC3037728, DOI: 10.1016/j.neuron.2010.01.035.Peer-Reviewed Original ResearchConceptsEye-specific segregationCentral nervous systemRetinal ganglion cellsDendritic motilitySynaptic activityActivity-dependent synapse formationPossible retinal originRGC axon projectionImmune proteinsImmune-deficient miceDendritic densityGanglion cellsClass I major histocompatibility complex genesRetinal originNervous systemSynapse formationAxon projectionsMHCI receptorNeural circuitsSynaptic wiringSelective defectMajor histocompatibility complex (MHC) genesMiceRetinaNormal development
2008
Mechanisms of response homeostasis during retinocollicular map formation
Shah RD, Crair MC. Mechanisms of response homeostasis during retinocollicular map formation. The Journal Of Physiology 2008, 586: 4363-4369. PMID: 18617562, PMCID: PMC2614012, DOI: 10.1113/jphysiol.2008.157222.Peer-Reviewed Original ResearchConceptsResponse homeostasisSynaptic plasticityIntrinsic excitabilityRetinocollicular map formationActivity-dependent developmentMouse superior colliculusHomeostatic plasticity mechanismsTotal synaptic inputReceptive fieldsDifferent mutant miceVisual receptive fieldsStrength of synapsesDifferent cellular mechanismsHebbian synaptic plasticityNeuronal outputSynaptic inputsSuperior colliculusRunaway excitationSynaptic scalingMutant miceNeural circuitsFunctional connectivityIndividual neuronsHomeostatic mechanismsCellular mechanismsCortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development
Iwasato T, Inan M, Kanki H, Erzurumlu RS, Itohara S, Crair MC. Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development. Journal Of Neuroscience 2008, 28: 5931-5943. PMID: 18524897, PMCID: PMC2733830, DOI: 10.1523/jneurosci.0815-08.2008.Peer-Reviewed Original ResearchConceptsTC synapsesLayer IV barrel neuronsCritical period plasticityPrimary somatosensory cortexFormation of barrelsAdenylyl cyclase 1Knock-out (KO) miceType 1 adenylyl cyclaseDendritic asymmetryBarrel neuronsThalamocortical synapsesActivity-dependent mannerTrigeminal pathwayFormation of cAMPSomatosensory cortexBarrel cortexBarrel developmentSynapse maturationPresynaptic maturationBarrel hollowsTC axonsSubcortical regionsFunctional maturationMutant miceBRL miceRetinocollicular Synapse Maturation and Plasticity Are Regulated by Correlated Retinal Waves
Shah RD, Crair MC. Retinocollicular Synapse Maturation and Plasticity Are Regulated by Correlated Retinal Waves. Journal Of Neuroscience 2008, 28: 292-303. PMID: 18171946, PMCID: PMC6671137, DOI: 10.1523/jneurosci.4276-07.2008.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornBehavior, AnimalDose-Response Relationship, RadiationElectric StimulationExcitatory Amino Acid AntagonistsIn Vitro TechniquesMiceMice, KnockoutNeuronal PlasticityN-MethylaspartatePatch-Clamp TechniquesQuinoxalinesReceptors, NicotinicRetinaSuperior ColliculiSynapsesSynaptic TransmissionVisual PathwaysConceptsFirst postnatal weekRetinal wavesPostnatal weekSynapse maturationAMPA/NMDA ratioRetinotopic map refinementSpontaneous retinal wavesNicotinic ACh receptorsSecond postnatal weekRetinocollicular synapsesSynapses decreasesPattern of activationNMDA ratioSynaptic strengtheningACh receptorsQuantal amplitudeRetinotopic map formationSuperior colliculusControl synapsesSynaptic changesCoincident activityPlasticity protocolsFirst weekBeta2 subunitWeeks
2007
Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice
Albright MJ, Weston MC, Inan M, Rosenmund C, Crair MC. Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice. Journal Of Neurophysiology 2007, 98: 1610-1625. PMID: 17581849, DOI: 10.1152/jn.00219.2007.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsField excitatory postsynaptic potentialsGAP-43Thalamocortical synapsesSynaptic responsesCompetitive glutamate receptor antagonistN-methyl-D-aspartate receptorsAcute brain slice preparationBarrel map formationThalamocortical synaptic responsesWild-type littermate controlsGlutamate receptor antagonistsBrain slice preparationGrowth-associated proteinThalamic innervationThalamic neuronsBarrel mapReceptor antagonistIsoxazolepropionate (AMPA) receptorsPostsynaptic potentialsLayer IVSlice preparationBarrel cortexSynaptic transmissionAMPAR functionDevelopmental Homeostasis of Mouse Retinocollicular Synapses
Chandrasekaran AR, Shah RD, Crair MC. Developmental Homeostasis of Mouse Retinocollicular Synapses. Journal Of Neuroscience 2007, 27: 1746-1755. PMID: 17301182, PMCID: PMC6673732, DOI: 10.1523/jneurosci.4383-06.2007.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornBrain MappingExcitatory Amino Acid AgonistsHomeostasisMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutModels, BiologicalNeuronsN-MethylaspartateReceptors, NicotinicRetinaSuperior ColliculiSynapsesVisual CortexVisual PathwaysConceptsRetinal wavesBeta2-/- miceSpontaneous retinal wavesRetinal ganglion cellsWild-type miceActivity-dependent competitionFirst postnatal weekTotal integrated responseLarge retinal areasTotal synaptic inputNeuronal receptive fieldsReceptive fieldsGanglion cellsPerturbation of activitiesSynaptic transmissionPostnatal weekResponse homeostasisSynaptic inputsRetinal areaRetinal inputSuperior colliculusStrong synapsesVisual cortexMutant miceRetinotopic mapping
2005
Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components
Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ. Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components. Neuron 2005, 46: 219-232. PMID: 15848801, DOI: 10.1016/j.neuron.2005.02.029.Peer-Reviewed Original ResearchConceptsExocyst componentsComplex of proteinsCell polaritySec15Specific cell adhesionSpecific proteinsMutant neuronsSubcellular distributionCell adhesionCell lethalityExocystNeuronal targetingSec5Neurite outgrowthSynaptic specificityCell viabilityProteinSeparable functionsSec6Sec8SubcomplexMislocalizationYeastGenesComponents persist
2001
Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition
Lu H, Gonzalez E, Crair M. Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition. Neuron 2001, 32: 619-634. PMID: 11719203, DOI: 10.1016/s0896-6273(01)00501-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingCritical Period, PsychologicalExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalLong-Term PotentiationMiceMice, Inbred C57BLMice, KnockoutNeuronal PlasticityPiperidinesQuinoxalinesReceptors, AMPAReceptors, N-Methyl-D-AspartateSomatosensory CortexSynapsesThalamusConceptsNMDA receptor subunit compositionReceptor subunit compositionSubunit compositionMouse somatosensory barrel cortexCritical periodNR2A knockout miceCritical period plasticitySomatosensory barrel cortexNMDAR subunit compositionCurrent kineticsAfferent innervationBarrel cortexNR2B subunitKnockout miceSynaptic plasticityNR2A subunitPlasticity windowSubunits
1997
Silent Synapses during Development of Thalamocortical Inputs
Isaac J, Crair M, Nicoll R, Malenka R. Silent Synapses during Development of Thalamocortical Inputs. Neuron 1997, 18: 269-280. PMID: 9052797, DOI: 10.1016/s0896-6273(00)80267-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesThalamocortical inputsSilent synapsesFunctional synapsesPostnatal day 8Rat somatosensory cortexActivity-dependent mechanismsActivity-dependent increaseEarly postnatal developmentSomatosensory cortexPostsynaptic activityTopographical projectionDay 8Postnatal developmentSynaptic connectionsSynaptic strengthSynapsesCortexSignificant proportionThalamusEarly developmentPotentiation
1995
A critical period for long-term potentiation at thalamocortical synapses
Crair M, Malenka R. A critical period for long-term potentiation at thalamocortical synapses. Nature 1995, 375: 325-328. PMID: 7753197, DOI: 10.1038/375325a0.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesNMDA receptor-mediated synaptic currentsN-methyl-D-aspartate receptor-dependent long-term potentiationReceptor-mediated synaptic currentsCritical periodRat somatosensory cortexActivity-dependent processesSomatosensory cortexThalamic axonsCortical circuitryNormal connectivitySynaptic currentsTopographical projectionSynaptic connectionsWhisker barrelsLoss of susceptibilitySensory perturbationsLTPPotentiationCortexSynapsesNormal developmentCompelling evidenceLikely mechanism