2007
Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice
Albright MJ, Weston MC, Inan M, Rosenmund C, Crair MC. Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice. Journal Of Neurophysiology 2007, 98: 1610-1625. PMID: 17581849, DOI: 10.1152/jn.00219.2007.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsField excitatory postsynaptic potentialsGAP-43Thalamocortical synapsesSynaptic responsesCompetitive glutamate receptor antagonistN-methyl-D-aspartate receptorsAcute brain slice preparationBarrel map formationThalamocortical synaptic responsesWild-type littermate controlsGlutamate receptor antagonistsBrain slice preparationGrowth-associated proteinThalamic innervationThalamic neuronsBarrel mapReceptor antagonistIsoxazolepropionate (AMPA) receptorsPostsynaptic potentialsLayer IVSlice preparationBarrel cortexSynaptic transmissionAMPAR function
1999
The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons
Zhou C, Qiu Y, Pereira F, Crair M, Tsai S, Tsai M. The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons. Neuron 1999, 24: 847-859. PMID: 10624948, DOI: 10.1016/s0896-6273(00)81032-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimetabolitesAxonsBromodeoxyuridineCarbocyaninesCell DeathCell DifferentiationCerebral CortexCOUP Transcription Factor IDNA-Binding ProteinsFluorescent DyesImmunohistochemistryIn Situ HybridizationMaleMiceMutationNeural PathwaysNeuronsReceptors, GlucocorticoidThalamusTranscription FactorsConceptsSubplate neuronsThalamocortical projectionsCortical layer IVLayer IV neuronsCell deathCorticothalamic connectivityAfferent innervationCerebral cortexThalamocortical axonsLayer IVNervous systemExcessive cell deathFactor INeuronal developmentNeuronsNuclear receptorsPremature cell deathInnervationImproper differentiationImportant regulatorOrphan memberDeathCritical roleDifferentiationFailureAltered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording
Higashi S, Crair MC, Kurotani T, Inokawa H, Toyama K. Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording. Neuroscience 1999, 91: 439-452. PMID: 10366001, DOI: 10.1016/s0306-4522(98)00666-6.Peer-Reviewed Original ResearchConceptsInfraorbital nerve cutNerve cutNormal ratsLayer IVSomatosensory cortexDextran amine labelingThalamocortical slice preparationPostnatal day 7Cytochrome oxidase stainingThalamocortical transmissionThalamocortical connectionsDextran amineThalamocortical axonsThalamic stimulationBarrel cortexFunctional synapsesSlice preparationAxon terminalsVoltage-sensitive dyeTerminal arborsAltered spatial patternDay 7P5-P6RatsBarrel formation
1998
Morphology of Single Geniculocortical Afferents and Functional Recovery of the Visual Cortex after Reverse Monocular Deprivation in the Kitten
Antonini A, Gillespie DC, Crair MC, Stryker MP. Morphology of Single Geniculocortical Afferents and Functional Recovery of the Visual Cortex after Reverse Monocular Deprivation in the Kitten. Journal Of Neuroscience 1998, 18: 9896-9909. PMID: 9822746, PMCID: PMC2452997, DOI: 10.1523/jneurosci.18-23-09896.1998.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusMonocular deprivationFunctional recoveryGeniculocortical afferentsArea 17Visual cortical responsesInitial deprivationSimilar proportional changesTotal arbor lengthPossible anatomical basisLayer IVArbor lengthGeniculate nucleusCortical responsesAfferent arborsSecond deprivationLamina ANormal animalsVisual cortexPlastic changesAnatomical basisInitial weeksArborsEyesAfferents