2011
A Synaptic Mechanism for Retinal Adaptation to Luminance and Contrast
Jarsky T, Cembrowski M, Logan SM, Kath WL, Riecke H, Demb JB, Singer JH. A Synaptic Mechanism for Retinal Adaptation to Luminance and Contrast. Journal Of Neuroscience 2011, 31: 11003-11015. PMID: 21795549, PMCID: PMC3152984, DOI: 10.1523/jneurosci.2631-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAmacrine CellsAnimalsBiophysical PhenomenaBiophysicsCalciumContrast SensitivityElectric StimulationExcitatory Postsynaptic PotentialsFemaleIn Vitro TechniquesLightingMaleMiceMice, Inbred C57BLModels, NeurologicalNumerical Analysis, Computer-AssistedPatch-Clamp TechniquesPhotic StimulationPresynaptic TerminalsRetinaRetinal Bipolar CellsSynaptic TransmissionConceptsSynaptic mechanismsSynaptic transmissionBipolar cell synaptic transmissionMouse retinal slice preparationVesicle depletionCommon synaptic mechanismsPrimary sensory circuitsUse-dependent regulationAII amacrine cellsContrast adaptationRetinal slice preparationBipolar cell synapsesCell synaptic transmissionRetinal neural circuitWhole-cell recordingsRetinal bipolar cellsPhasic transmissionTonic transmissionAmacrine cellsSlice preparationCell synapsesBipolar cellsSame cellular mechanismsSensory circuitsNeural circuits
2010
NMDA Receptor Contributions to Visual Contrast Coding
Manookin MB, Weick M, Stafford BK, Demb JB. NMDA Receptor Contributions to Visual Contrast Coding. Neuron 2010, 67: 280-293. PMID: 20670835, PMCID: PMC2913150, DOI: 10.1016/j.neuron.2010.06.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsContrast SensitivityDizocilpine MaleateElectric ConductivityExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGene Expression RegulationGuinea PigsIn Vitro TechniquesLightMiceMice, Inbred C57BLN-MethylaspartatePatch-Clamp TechniquesPhotic StimulationPiperidinesReceptors, N-Methyl-D-AspartateRetinaRetinal Ganglion CellsVisual PerceptionConceptsNMDA receptorsOFF alphaAlpha cellsNMDA-type glutamate receptorsOFF alpha cellsDelta cellsGanglion cell typesNMDA receptor contributionCell typesExcitatory responsesGlutamate receptorsInhibitory currentsAMPA receptorsReceptor contributionGluN2B subunitContrast sensitivityContrast codingReceptorsNMDAAMPACertain cell typesCellsVisual processingAlpha
2008
Distinct expressions of contrast gain control in parallel synaptic pathways converging on a retinal ganglion cell
Beaudoin DL, Manookin MB, Demb JB. Distinct expressions of contrast gain control in parallel synaptic pathways converging on a retinal ganglion cell. The Journal Of Physiology 2008, 586: 5487-5502. PMID: 18832424, PMCID: PMC2655385, DOI: 10.1113/jphysiol.2008.156224.Peer-Reviewed Original ResearchConceptsCone bipolar cellsOFF ganglion cellsRod bipolar cellsGanglion cellsRetinal ganglion cellsBipolar cellsInhibitory inputsExcitatory inputsSynaptic pathwaysContrast gain controlOFF cone bipolar cellsIonotropic glutamate receptor antagonistsY-type ganglion cellsRod bipolar pathwayAII amacrine cellsGlutamate receptor antagonistsGanglion cell firingWhole-cell recordingsLoose-patch recordingsAmacrine cellsReceptor antagonistRetinal pathwaysAII cellsSynaptic mechanismsSynaptic currentsFunctional circuitry of visual adaptation in the retina
Demb JB. Functional circuitry of visual adaptation in the retina. The Journal Of Physiology 2008, 586: 4377-4384. PMID: 18617564, PMCID: PMC2614018, DOI: 10.1113/jphysiol.2008.156638.Peer-Reviewed Original ResearchConceptsPresynaptic bipolar cellsGanglion cellsReceptive field centerBipolar cellsGanglion cell receptive field centersPeripheral receptive fieldsBipolar cell inputsContrast adaptationRetinal ganglion cellsBipolar terminalsGlutamate releaseAmacrine cellsSynaptic outputMammalian retinaContrast stimulationFunctional circuitryCellular mechanismsSpike generationCell inputHyperpolarizationReceptive fieldsRetinaResponse saturationField centerCells
2007
Cellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells
Beaudoin DL, Borghuis BG, Demb JB. Cellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells. Journal Of Neuroscience 2007, 27: 2636-2645. PMID: 17344401, PMCID: PMC6672510, DOI: 10.1523/jneurosci.4610-06.2007.Peer-Reviewed Original ResearchConceptsReceptive field centerPresynaptic bipolar cellsGanglion cellsBipolar cellsAmacrine cellsGanglion cell receptive field centersContrast gain controlMammalian retinal ganglion cellsMammalian ganglion cellsRetinal ganglion cellsWhole-cell recordingsInhibitory neurotransmitter receptorsField centerVoltage-clamp conditionsInhibitory interneuronsSynaptic releaseNeurotransmitter receptorsCenter responseExtracellular recordingsPharmacological conditionsAdequate stimulationInhibitory conductanceCalcium bufferingSubthreshold responsesMembrane currents
2006
Presynaptic Mechanism for Slow Contrast Adaptation in Mammalian Retinal Ganglion Cells
Manookin MB, Demb JB. Presynaptic Mechanism for Slow Contrast Adaptation in Mammalian Retinal Ganglion Cells. Neuron 2006, 50: 453-464. PMID: 16675399, DOI: 10.1016/j.neuron.2006.03.039.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdaptation, PhysiologicalAnimalsCalcium ChannelsContrast SensitivityGlutamic AcidGuinea PigsOrgan Culture TechniquesPhotic StimulationPresynaptic TerminalsReaction TimeReceptors, GABAReceptors, GlycineReceptors, Metabotropic GlutamateRetinal Bipolar CellsRetinal Ganglion CellsSynaptic TransmissionConceptsPresynaptic bipolar cellsRetinal ganglion cellsGanglion cellsBipolar cellsMammalian retinal ganglion cellsSlow contrast adaptationReduced glutamate releaseIntrinsic cellular propertiesIntrinsic cellular mechanismsCortical adaptationGlutamate releasePresynaptic mechanismsGlycine receptorsVisual neuronsAfterhyperpolarizationExcitatory conductancePotassium conductanceContrast adaptationCellular mechanismsCortical cellsNeuronsCellsCellular propertiesMGluRsSpatial stimuli
2005
Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Boahen K, Demb JB. Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neuroscience 2005, 25: 860-868. PMID: 15673666, PMCID: PMC6725633, DOI: 10.1523/jneurosci.2782-04.2005.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsIntracellular recordingsSubthreshold responsesY-type retinal ganglion cellsY-type ganglion cellsSynaptic mechanismsSynaptic inputsMammalian retinaSpiking responseExtracellular recordingsSubthreshold potentialsContrast sensitivitySpike outputSpike thresholdContrast adaptationSpike generationGain changesCellsRecordingsResponseApparent reductionRecording conditionsAbove effectsMean light level
2004
How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output
Demb JB, Sterling P, Freed MA. How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output. Journal Of Neurophysiology 2004, 92: 2510-2519. PMID: 15175375, DOI: 10.1152/jn.00108.2004.Peer-Reviewed Original ResearchConceptsSynaptic convergenceSpike outputGanglion cellsIntracellular recordingsSynaptic inputsSpike responsesF1 responseRetinal ganglion cellsSpike rateNeuron synaptic inputsPrimary visual cortexExtracellular recordingsVisual cortexPeak depolarizationStimulus frequencyStimulus cycleSynaptic vesiclesStimulus contrastStrong stimulusSynaptic noiseDepolarizationNeuronsParadoxical findingsMembrane potentialSame cells
2003
Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities
Zaghloul KA, Boahen K, Demb JB. Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities. Journal Of Neuroscience 2003, 23: 2645-2654. PMID: 12684450, PMCID: PMC6742092, DOI: 10.1523/jneurosci.23-07-02645.2003.Peer-Reviewed Original ResearchConceptsOFF cellsGanglion cellsSynaptic inputsContrast sensitivityExcitatory conductanceOFF retinal ganglion cellsOFF ganglion cellsBasal glutamate releaseRetinal ganglion cellsBrisk-transient cellsGuinea pig retinaBipolar terminalsPresynaptic circuitsGlutamate releaseIntracellular recordingsON pathwayPig retinaSubthreshold membrane potentialsLight incrementsL-APMembrane potentialCellsMean luminancePathwayRetina
2002
Multiple Mechanisms for Contrast Adaptation in the Retina
Demb JB. Multiple Mechanisms for Contrast Adaptation in the Retina. Neuron 2002, 36: 781-783. PMID: 12467580, DOI: 10.1016/s0896-6273(02)01100-5.Commentaries, Editorials and Letters
1999
Neuronal basis of contrast discrimination
Boynton G, Demb J, Glover G, Heeger D. Neuronal basis of contrast discrimination. Vision Research 1999, 39: 257-269. PMID: 10326134, DOI: 10.1016/s0042-6989(98)00113-8.Peer-Reviewed Original ResearchMeSH KeywordsContrast SensitivityHumansMagnetic Resonance ImagingPhotic StimulationPsychophysicsVisual CortexConceptsVisual cortical areasAverage neuronal activityFunctional magnetic resonance imagingFMRI responsesNeuronal activityCortical areasEarly visual cortical areasMagnetic resonance imagingVisual areas V1Contrast increment thresholdsIncrement thresholdsEarly visual cortexNeuronal responsesBrain areasVisual cortexResonance imagingArea V1Neuronal basisPooled activityStimulus intervalStimulus contrastBaseline contrastNeuronal signalsBrain activityHuman brain activity
1998
Psychophysical evidence for a magnocellular pathway deficit in dyslexia
Demb J, Boynton G, Best M, Heeger D. Psychophysical evidence for a magnocellular pathway deficit in dyslexia. Vision Research 1998, 38: 1555-1559. PMID: 9747491, DOI: 10.1016/s0042-6989(98)00075-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultContrast SensitivityDyslexiaFemaleHumansMaleMotion PerceptionPsychophysicsSensory ThresholdsTime FactorsVisual PathwaysConceptsSpeed discriminationPsychophysical performanceMagnocellular pathway deficitIndividual differencesPsychophysical evidenceMotion discriminationPsychophysical predictorsDyslexiaDetection taskMagnocellular pathwayPsychophysical thresholdsPathway deficitsContrast sensitivityDeficitsDiscriminationPathway integritySpeed thresholdTaskHypothesisPathway abnormalitiesPredictorsDetection thresholdPerformance