2023
Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy
Spadaro J, Chow R, Sinard J, Watsky K, Habib L. Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: e78-e81. PMID: 36852835, DOI: 10.1097/iop.0000000000002338.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaLow-dose radiation therapyPeriorbital edemaRadiation therapyChronic Lymphocytic Leukemia PresentingBilateral periorbital edemaLeukemia cutisOcular involvementOcular manifestationsPrompt diagnosisBlood dyscrasiasCase reportNeoplastic lymphocytesLymphocytic leukemiaTissue infiltrationTherapeutic interventionsEdemaPatientsTherapyLeukemiaInfiltrationEcchymosisPresentingDyscrasiasLymphocytes
2022
Systems approach to enhance Lynch syndrome diagnosis through tumour testing
Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.Peer-Reviewed Original ResearchConceptsOriginal cohortColorectal adenocarcinomaLynch syndromeTumor testingGenetic testingPercentage of patientsProportion of patientsLynch syndrome diagnosisCG evaluationCancer genetic testingRace/ethnicityCRC testingCohort studyMMR immunohistochemistryLS diagnosisNew diagnosisMMR lossAcademic centersPatientsSyndrome diagnosisCohortCase identificationMethylation testingReferral differencesReferral mechanisms
2021
Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review
Abdel-Aty A, Linderman WL, Kombo N, Sinard J, Pointdujour-Lim R. Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review. Ocular Oncology And Pathology 2021, 8: 1-8. PMID: 35356597, PMCID: PMC8914239, DOI: 10.1159/000515558.Peer-Reviewed Original ResearchOrbital cellulitisOrbital inflammationUveal melanomaVision lossIntraocular malignancyNecrotic uveal melanomaCommon primary intraocular malignancyPainless vision lossPrimary intraocular malignancyUveal melanoma presentingMelanoma presentingExtraocular movementsTumor necrosisCellulitisMelanomaInflammationPatientsMalignancyReviewReportAutoinfarctionProptosisPainPresentingSymptoms
2020
Pulmonary Adenocarcinoma Metastatic to Periocular Skin and Orbital Tissue Presenting as Orbital Cellulitis.
Li E, Sinard J, Sohrab M. Pulmonary Adenocarcinoma Metastatic to Periocular Skin and Orbital Tissue Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 2020, 36: e28-e30. PMID: 31789787, DOI: 10.1097/iop.0000000000001534.Peer-Reviewed Original ResearchConceptsOrbital inflammationAdenocarcinoma metastaticMetastatic lung cancerLife-saving managementIntraorbital soft tissuesBroad-spectrum antibioticsOccult malignancyAdjuvant radiationSystemic chemotherapyInitial presentationOrbital cellulitisLung cancerPeriocular skinSubcutaneous massHigh indexTissue biopsiesSoft tissueMetastaticBiopsyInflammationDiagnosisFirst reportCellulitisChemotherapyPatients
2019
Dabrafenib and Trametinib for BRAF-Mutated Conjunctival Melanoma
Kim JM, Weiss S, Sinard JH, Pointdujour-Lim R. Dabrafenib and Trametinib for BRAF-Mutated Conjunctival Melanoma. Ocular Oncology And Pathology 2019, 6: 35-38. PMID: 32002403, PMCID: PMC6984155, DOI: 10.1159/000497473.Peer-Reviewed Original ResearchImmune Checkpoint Inhibitor–Associated Pericarditis
Altan M, Toki MI, Gettinger SN, Carvajal-Hausdorf DE, Zugazagoitia J, Sinard JH, Herbst RS, Rimm DL. Immune Checkpoint Inhibitor–Associated Pericarditis. Journal Of Thoracic Oncology 2019, 14: 1102-1108. PMID: 30851443, PMCID: PMC6617516, DOI: 10.1016/j.jtho.2019.02.026.Peer-Reviewed Original ResearchConceptsAdverse eventsCTLA-4 inhibitorsImmune checkpoint inhibitorsDeath-1/Pericardial window procedureCheckpoint inhibitorsThird patientClinical presentationCardiac toxicityHistopathologic findingsSide effectsPericarditisPatientsDeath ligandsPotential mechanismsWindow procedureInhibitorsImmunotherapyNSCLCCardiotoxicityAutopsiesTherapy
2018
Optimal Intraoperative Assessment of Gastric Margins
Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.Peer-Reviewed Original ResearchConceptsIntraoperative pathology consultationGastric marginPositive marginsTumor distanceMajority of casesRepresentative sectionsR0 resectionConsecutive patientsGastroesophageal junctionTumor sizeNegative marginsPatient outcomesIntraoperative assessmentPathology consultationPatientsStrong associationMargin assessment
2017
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma
Tainsh LT, Coady PA, Sinard JH, Neparidze N, Meskin SW, Adelman RA, Chow J. Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. Cornea 2017, 36: 372-374. PMID: 28079685, DOI: 10.1097/ico.0000000000001139.Peer-Reviewed Original ResearchConceptsMultiple myelomaVisual acuityRight eye 2 yearsDeep stromal opacitiesEye 2 yearsPatient's visual acuityDiagnosis of IgGParaproteinemic keratopathyInitial presentationStromal lesionsStromal opacityCase reportHematologic workupMonoclonal gammopathyAsymmetric presentationUnusual casePosterior stromaMyelomaKeratopathyPatientsDiagnosisPresentationLiterature reviewKeratoplastyAcuity
2016
Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid
Gaudio PA, Sinard J, Shield DR, Huang JJ, King BA. Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid. Ocular Immunology And Inflammation 2016, 26: 70-73. PMID: 27437791, DOI: 10.1080/09273948.2016.1194435.Peer-Reviewed Original ResearchConceptsImmunomodulatory therapyConjunctival biopsyAntibody depositionOcular mucous membrane pemphigoidPost-treatment biopsiesMucous membrane pemphigoidEfficacy of therapyConjunctival basement membraneInactive diseaseBiopsy findingsChronic diseasesBiopsyPatient biopsiesPatientsTherapyBasement membraneDiseaseImmunofluorescence microscopyMMPsPemphigoidYearsFindings
2001
Factors Affecting Autopsy Rates, Autopsy Request Rates, and Autopsy Findings at a Large Academic Medical Center
Sinard J. Factors Affecting Autopsy Rates, Autopsy Request Rates, and Autopsy Findings at a Large Academic Medical Center. Experimental And Molecular Pathology 2001, 70: 333-343. PMID: 11418012, DOI: 10.1006/exmp.2001.2371.Peer-Reviewed Original ResearchConceptsAcademic medical centerEmergency departmentAutopsy rateFetal deathPediatric deathsMedical CenterLarge academic medical centerGeneral surgery serviceEmergency department deathsMajor academic medical centerPercentage of casesSignificant unexpected findingsHospital deathAdult patientsPatient ageSurgery serviceAutopsy findingsPatient deathAutopsy examinationClinical assessmentCardiothoracic surgeryMedicine servicePatientsDeathGreater increase
1998
Orbital Melanoma Presenting as Orbital Cellulitis
Fezza J, Chaudhry I, Kwon Y, Grannum E, Sinard J, Wolfley D. Orbital Melanoma Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 1998, 14: 286-289. PMID: 9700739, DOI: 10.1097/00002341-199807000-00012.Peer-Reviewed Original ResearchConceptsOrbital cellulitisChoroidal melanomaMost choroidal melanomasNecrotic choroidal melanomaSpindle B melanomaIntraocular involvementMelanoma presentingOrbital inflammationPostoperative radiationAcute infectionEpithelioid areasEarly suspicionHistopathologic analysisMelanomaTumorsCellulitisLesionsBest chanceInflammationPatientsPresentingMalignancyEnucleationInfectionSuspicion
1997
Metastatic Liposarcoma to the Orbit
Fezza J, Sinard J. Metastatic Liposarcoma to the Orbit. American Journal Of Ophthalmology 1997, 123: 271-272. PMID: 9186144, DOI: 10.1016/s0002-9394(14)71055-4.Peer-Reviewed Original ResearchConceptsVisual acuityHistory of liposarcomaPatient's visual acuityRare orbital tumorIntravenous corticosteroidsOrbital liposarcomaMetastatic liposarcomaOrbital biopsyBlurred visionDedifferentiated liposarcomaOrbital tumorsLiposarcomaHigh gradeProptosisPatientsCorticosteroidsBiopsyAcuityRecurrenceMalignancyTumorsAbdomenPhysiciansPathology
1994
Cardiogenic Shock Due to Progression of Cutaneous T-Cell Lymphoma
COOPER D, SINARD J, EDELSON R, FLYNN S. Cardiogenic Shock Due to Progression of Cutaneous T-Cell Lymphoma. Southern Medical Journal 1994, 87: 89-94. PMID: 8284728, DOI: 10.1097/00007611-199401000-00021.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaCardiac involvementProgressive cutaneous T-cell lymphomaCardiogenic shockClinical suspicionHematogenous spreadEndomyocardial biopsyCardiac failureLymphomatous involvementCardiac enlargementConduction disturbancesSingle symptomTumor cellsPatientsLymphomaReasonable chanceInvolvementEchocardiographyChemotherapyTachyarrhythmiasBiopsySymptomsMyocardiumSuspicion