2024
Specific retinal neurons regulate context-dependent defensive responses to visual threat
Lee T, Weinberg-Wolf H, Zapadka T, Rudenko A, Demb J, Kim I. Specific retinal neurons regulate context-dependent defensive responses to visual threat. PNAS Nexus 2024, 3: pgae423. PMID: 39359403, PMCID: PMC11443969, DOI: 10.1093/pnasnexus/pgae423.Peer-Reviewed Original ResearchRetinal ganglion cellsBehavioral responsesRetinal ganglion cell typesVisual threatAlpha retinal ganglion cellsLooming stimuliThreatening stimuliMature miceGanglion cellsBehavioral reactionsUnique contributionsCell ablationVisual pathwayOutput neuronsEarly visual pathwayStimuliContextual signalsDefense responsesAerial predatorsEnvironmental context
2021
Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Reports 2021, 34: 108777. PMID: 33657370, PMCID: PMC8009559, DOI: 10.1016/j.celrep.2021.108777.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCRISPR-Cas SystemsDependovirusFemaleGene EditingGene Expression RegulationGenetic Association StudiesHEK293 CellsHumansInterleukinsMaleMAP Kinase Kinase KinasesMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisOptic NerveOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionSTAT3 Transcription FactorConceptsOptic nerve crushRetinal ganglion cellsRegeneration-associated genesShort hairpin RNAIL-22Neural repairCentral nervous system traumaNeurological deficits persistNervous system traumaNerve crushAxonal damageAxonal regenerationGanglion cellsSystem traumaInflammatory responseCNS regenerationDeficits persistAxonal growthHairpin RNAConcurrent activationTranscription 3Cell-autonomous factorsKinase pathwaySignal transducerRepair
2015
Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling
Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling. Neuron 2015, 85: 1244-1256. PMID: 25754821, PMCID: PMC4391013, DOI: 10.1016/j.neuron.2015.02.017.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsDownregulation of PTENGanglion cellsInsulin-like growth factor-1Mouse retinal ganglion cellsAdministration of osteopontinAbility of RGCsSubtype-specific differencesGrowth factor-1Effect of osteopontinAxonal regenerationIGF-1High mTORSurvival rateΑRGCsMTOR pathwayPromising agentAxotomyMTOR signalingDistinct subsetsFactor 1Existence of subpopulationsInjuryOsteopontinDownregulation
2012
The most numerous ganglion cell type of the mouse retina is a selective feature detector
Zhang Y, Kim IJ, Sanes JR, Meister M. The most numerous ganglion cell type of the mouse retina is a selective feature detector. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e2391-e2398. PMID: 22891316, PMCID: PMC3437843, DOI: 10.1073/pnas.1211547109.Peer-Reviewed Original ResearchConceptsGanglion cellsBipolar cellsMouse retinaW3 cellsGanglion cell typesRetinal ganglion cellsStrong lateral inhibitionReceptive field sizeDifferent visual inputsHuman retinaRetinaNeural imagesCell poolCommon visual stimuliReceptive fieldsVisual stimuliVisual inputCell typesUnusual conditionVisual sceneResponse propertiesCellsLateral inhibitionDistinct populationsNaturalistic stimuli
2010
Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers
Kim IJ, Zhang Y, Meister M, Sanes JR. Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers. Journal Of Neuroscience 2010, 30: 1452-1462. PMID: 20107072, PMCID: PMC2822471, DOI: 10.1523/jneurosci.4779-09.2010.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsEarly postnatal stagesRGC subsetsSuperior colliculusSubset of RGCsRetinal ganglion cell dendritesPostnatal stagesGanglion cell dendritesInner plexiform layerLateral geniculate nucleusDevelopment of RGCsSpecific sublaminaeDistinct functional signaturesSubpial zoneGanglion cellsPlexiform layerCell dendritesAxonal projectionsDendritic arborsGeniculate nucleusSubtype-specific featuresAxonal arborsRetinorecipient layersMouse transgenic linesDiffuse pattern
2008
Molecular identification of a retinal cell type that responds to upward motion
Kim IJ, Zhang Y, Yamagata M, Meister M, Sanes JR. Molecular identification of a retinal cell type that responds to upward motion. Nature 2008, 452: 478-482. PMID: 18368118, DOI: 10.1038/nature06739.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRetinal cell typesGanglion cellsRetinal neuronsNeural circuitsNeuronsCircuit functionCell typesCellsMice