2020
Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival
Chande S, Caballero D, Ho BB, Fetene J, Serna J, Pesta D, Nasiri A, Jurczak M, Chavkin NW, Hernando N, Giachelli CM, Wagner CA, Zeiss C, Shulman GI, Bergwitz C. Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival. Scientific Reports 2020, 10: 3069. PMID: 32080237, PMCID: PMC7033257, DOI: 10.1038/s41598-020-59430-4.Peer-Reviewed Original ResearchConceptsHyp miceMuscle functionSkeletal muscleMyofiber functionNormal body weightSkeletal muscle atrophyGene dose-dependent reductionConditional knockout miceReduced oxygen consumption rateStimulation of AMP kinaseKnockout miceHypophosphatemic disordersMuscle atrophyERK1/2 activationGrip strengthConditional deletionHormonal changesLow bloodBody weightC2C12 myoblastsMiceFurther evaluationBlood phosphateDependent reductionAMP kinase
2003
The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice
Zeiss CJ. The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice. Veterinary Pathology 2003, 40: 481-495. PMID: 12949404, DOI: 10.1354/vp.40-5-481.Peer-Reviewed Original ResearchConceptsCell death programApoptosis-inducing factorTissue-specific rolesCaspase-dependent mechanismCaspase-dependent apoptosisApoptosis-necrosis continuumAnimal developmentDeath programKey genesApoptotic effectorsApoptotic phenotypeRegulated processCaspase activationIntimate crosstalkApoptotic cascadeDependent effectorsHomeostatic pathwaysCell deathNecrotic onesBiochemical networksApoptosisPathologic stimuliBiochemical featuresMutant miceGenes