2019
Menagerie: A text-mining tool to support animal-human translation in neurodegeneration research
Zeiss CJ, Shin D, Wyk B, Beck AP, Zatz N, Sneiderman CA, Kilicoglu H. Menagerie: A text-mining tool to support animal-human translation in neurodegeneration research. PLOS ONE 2019, 14: e0226176. PMID: 31846471, PMCID: PMC6917268, DOI: 10.1371/journal.pone.0226176.Peer-Reviewed Original Research
2018
Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing
Rindflesch TC, Blake CL, Cairelli MJ, Fiszman M, Zeiss CJ, Kilicoglu H. Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing. Journal Of Biomedical Semantics 2018, 9: 25. PMID: 30587224, PMCID: PMC6307110, DOI: 10.1186/s13326-018-0192-y.Peer-Reviewed Original ResearchMeSH KeywordsBrainData MiningEpilepsyGlutamic AcidHumansInflammatory Bowel DiseasesInterleukin-1betaMEDLINESemanticsConceptsInflammatory bowel diseaseInterleukin-1 betaBowel diseaseAdverse drug reactionsBetter healthcare outcomesElectronic health recordsDrug reactionsGlutamate levelsClinical dataEarlier population studiesStructured clinical dataEpilepsyHealthcare outcomesHealth recordsImproved treatmentDiseasePopulation studiesDrug developmentGlutamateBetaEtiologyMethodsInStudy
2017
Informatics Support for Basic Research in Biomedicine.
Rindflesch TC, Blake CL, Fiszman M, Kilicoglu H, Rosemblat G, Schneider J, Zeiss CJ. Informatics Support for Basic Research in Biomedicine. ILAR Journal 2017, 58: 80-89. PMID: 28838071, PMCID: PMC5886329, DOI: 10.1093/ilar/ilx004.Peer-Reviewed Original ResearchConceptsSemantic MEDLINEText mining techniquesDocument retrievalHigh-level connectionsMining techniquesBiomedical research literatureUse casesBiomedical entitiesRelation identificationComputer-assisted techniquesInformatics supportPubMed queryUsersInformatics methodologiesBiomedical researchersInformatics methodsResearch areaHypothesis formationBiomedical research areasIterative processLarge amountQueriesLarge numberRetrievalCurrent developments
2014
Improving the predictive value of interventional animal models data
Zeiss CJ. Improving the predictive value of interventional animal models data. Drug Discovery Today 2014, 20: 475-482. PMID: 25448761, PMCID: PMC4417064, DOI: 10.1016/j.drudis.2014.10.015.Peer-Reviewed Original ResearchConceptsAnimal studiesSignificant potential confoundersAnimal model dataPercent of interventionsMore animal modelsPotential confoundersChronic diseasesImproved outcomesAmyloid hypothesisAnimal modelsPredictive valueAlzheimer's diseasePositive outcomesDiseaseTranslational successOutcomesPositive-outcome biasInterventionAdditional mechanismAnimalsMemantineConfoundersDonepezil