2022
Microbiome and immune-mediated dry eye: a review
Watane A, Raolji S, Cavuoto K, Galor A. Microbiome and immune-mediated dry eye: a review. BMJ Open Ophthalmology 2022, 7: e000956. PMID: 36161855, PMCID: PMC9214397, DOI: 10.1136/bmjophth-2021-000956.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory AgentsAutoimmune DiseasesDry Eye SyndromesGastrointestinal MicrobiomeHumansMicrobiotaConceptsOcular surface microbiomeDry eyeAutoimmune diseasesFecal microbial transplantGut microbiome changesCertain autoimmune diseasesLymphocyte responsesMicrobial transplantTherapeutic strategiesImmune systemMicrobiome changesGut microbiomeDiseaseKey articlesEyesLess informationMicrobiome variesMicrobiome manipulationMicrobiomeSurface microbiomeReviewTransplantIndividualsSeverityDemographics
2021
Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye
Watane A, Cavuoto K, Rojas M, Dermer H, Day J, Banerjee S, Galor A. Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye. American Journal Of Ophthalmology 2021, 233: 90-100. PMID: 34214453, PMCID: PMC8678170, DOI: 10.1016/j.ajo.2021.06.022.Peer-Reviewed Original ResearchMeSH KeywordsDry Eye SyndromesFecal Microbiota TransplantationFecesGastrointestinal MicrobiomeHumansMaleMicrobiotaMiddle AgedTreatment OutcomeConceptsGut microbiome profilesT cell profileFecal microbial transplantDry eyeMicrobiome profilesMicrobial transplantDE symptomsRegulatory T-cell profilesDE symptom severityNonrandomized clinical trialPrimary outcome measureDonor microbiomeSingle healthy donorAdverse eventsMean ageClinical trialsHealthy donorsOutcome measuresStudy populationSymptom severityAdministration methodsBaseline profileGenus FaecalibacteriumTime pointsMonths
2020
Gut microbial dysbiosis in individuals with Sjögren’s syndrome
Mendez R, Watane A, Farhangi M, Cavuoto KM, Leith T, Budree S, Galor A, Banerjee S. Gut microbial dysbiosis in individuals with Sjögren’s syndrome. Microbial Cell Factories 2020, 19: 90. PMID: 32293464, PMCID: PMC7158097, DOI: 10.1186/s12934-020-01348-7.Peer-Reviewed Original ResearchMeSH KeywordsActinobacteriaAdultAgedBacteroidetesDysbiosisFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedSjogren's SyndromeConceptsHealthy controlsDE symptomsFull criteriaGut microbiomeGut microbial dysbiosisDepletion of FirmicutesExpansion of ProteobacteriaDry eyeSjögren's syndromeMicrobial dysbiosisMicrobiome alterationsDE measuresConclusionsIn conclusionMicrobial compositionEye measuresSyndromeSymptomsSjögrenDifferential clusteringAssociationSignsIndividualsPrinciple co-ordinate analysisPhylum levelMicrobiome