2022
Microbiome and immune-mediated dry eye: a review
Watane A, Raolji S, Cavuoto K, Galor A. Microbiome and immune-mediated dry eye: a review. BMJ Open Ophthalmology 2022, 7: e000956. PMID: 36161855, PMCID: PMC9214397, DOI: 10.1136/bmjophth-2021-000956.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory AgentsAutoimmune DiseasesDry Eye SyndromesGastrointestinal MicrobiomeHumansMicrobiotaConceptsOcular surface microbiomeDry eyeAutoimmune diseasesFecal microbial transplantGut microbiome changesCertain autoimmune diseasesLymphocyte responsesMicrobial transplantTherapeutic strategiesImmune systemMicrobiome changesGut microbiomeDiseaseKey articlesEyesLess informationMicrobiome variesMicrobiome manipulationMicrobiomeSurface microbiomeReviewTransplantIndividualsSeverityDemographics
2021
Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye
Watane A, Cavuoto K, Rojas M, Dermer H, Day J, Banerjee S, Galor A. Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye. American Journal Of Ophthalmology 2021, 233: 90-100. PMID: 34214453, PMCID: PMC8678170, DOI: 10.1016/j.ajo.2021.06.022.Peer-Reviewed Original ResearchMeSH KeywordsDry Eye SyndromesFecal Microbiota TransplantationFecesGastrointestinal MicrobiomeHumansMaleMicrobiotaMiddle AgedTreatment OutcomeConceptsGut microbiome profilesT cell profileFecal microbial transplantDry eyeMicrobiome profilesMicrobial transplantDE symptomsRegulatory T-cell profilesDE symptom severityNonrandomized clinical trialPrimary outcome measureDonor microbiomeSingle healthy donorAdverse eventsMean ageClinical trialsHealthy donorsOutcome measuresStudy populationSymptom severityAdministration methodsBaseline profileGenus FaecalibacteriumTime pointsMonths