2021
Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye
Watane A, Cavuoto K, Rojas M, Dermer H, Day J, Banerjee S, Galor A. Fecal Microbial Transplant in Individuals With Immune-Mediated Dry Eye. American Journal Of Ophthalmology 2021, 233: 90-100. PMID: 34214453, PMCID: PMC8678170, DOI: 10.1016/j.ajo.2021.06.022.Peer-Reviewed Original ResearchConceptsGut microbiome profilesT cell profileFecal microbial transplantDry eyeMicrobiome profilesMicrobial transplantDE symptomsRegulatory T-cell profilesDE symptom severityNonrandomized clinical trialPrimary outcome measureDonor microbiomeSingle healthy donorAdverse eventsMean ageClinical trialsHealthy donorsOutcome measuresStudy populationSymptom severityAdministration methodsBaseline profileGenus FaecalibacteriumTime pointsMonths
2020
Gut microbial dysbiosis in individuals with Sjögren’s syndrome
Mendez R, Watane A, Farhangi M, Cavuoto KM, Leith T, Budree S, Galor A, Banerjee S. Gut microbial dysbiosis in individuals with Sjögren’s syndrome. Microbial Cell Factories 2020, 19: 90. PMID: 32293464, PMCID: PMC7158097, DOI: 10.1186/s12934-020-01348-7.Peer-Reviewed Original ResearchConceptsHealthy controlsDE symptomsFull criteriaGut microbiomeGut microbial dysbiosisDepletion of FirmicutesExpansion of ProteobacteriaDry eyeSjögren's syndromeMicrobial dysbiosisMicrobiome alterationsDE measuresConclusionsIn conclusionMicrobial compositionEye measuresSyndromeSymptomsSjögrenDifferential clusteringAssociationSignsIndividualsPrinciple co-ordinate analysisPhylum levelMicrobiome