Skip to Main Content
Directory of Faculty Research Interests
YSM Home

INFORMATION FOR

DownloadHi-Res Photo

Yury M. Morozov, PhD

Research Scientist in Neuroscience

Contact Information

Yury M. Morozov, PhD
Rakic lab, Yale school of Medicine

Related Links

Research Summary

My current research is focused on the development of cerebral interneurons. I determined site and timing of origin and migratory routes of prospective cannabinoid type 1 receptor containing interneurons. I demonstrated that neurochemical properties and fate of this interneuronal subgroup, similar to the projection neurons, are determined at the time and place of last cell division (Cerebral Cortex, 2009). I demonstrated for the first time translocation of synaptically interconnected basket interneurons in the postnatal rat hippocampus what may occur in response to local functional demand and represents a novel mode of cell movement and form of neuroplasticity (J. Neurosci., 2006).

Coauthors

Research Interests

Central Nervous System; Neurodegenerative Diseases

Research Images

Mitochondrial unfinished fission
Mitochondrial initiated but unfinished fission in cerebral neurons correlates with the age of non-human primate.

Selected Publications

  • Disorder of Golgi Apparatus Precedes Anoxia-Induced Pathology of Mitochondria.Morozov Y, Rakic P. Disorder of Golgi Apparatus Precedes Anoxia-Induced Pathology of Mitochondria. International Journal Of Molecular Sciences 2023, 24: 4432. PMID: 36901863, PMCID: PMC10003327, DOI: 10.3390/ijms24054432.
  • Nanoscale imaging of pT217‐tau in aged rhesus macaque: Trans‐synaptic propagation and seeding of tau pathology in entorhinal cortexDatta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. Nanoscale imaging of pT217‐tau in aged rhesus macaque: Trans‐synaptic propagation and seeding of tau pathology in entorhinal cortex Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.064956.
  • P477. Anatomical Evaluation of Calcium-Related Schizophrenia Risk Genes in Rhesus Macaque Dorsolateral Prefrontal CortexDatta D, Mentone S, Morozov Y, Arnsten A. P477. Anatomical Evaluation of Calcium-Related Schizophrenia Risk Genes in Rhesus Macaque Dorsolateral Prefrontal Cortex Biological Psychiatry 2022, 91: s281-s282. DOI: 10.1016/j.biopsych.2022.02.713.
  • Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer’s diseaseDatta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer’s disease Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054671.
  • Subcellular Localization of Schizophrenia Risk Genes Encoding Cav1.2 (CACNA1C) and VIPR2 in Rhesus Macaque Dorsolateral Prefrontal CortexDatta D, Mentone S, Morozov Y, Arnsten A. Subcellular Localization of Schizophrenia Risk Genes Encoding Cav1.2 (CACNA1C) and VIPR2 in Rhesus Macaque Dorsolateral Prefrontal Cortex Biological Psychiatry 2021, 89: s308. DOI: 10.1016/j.biopsych.2021.02.768.
  • The calcium‐containing smooth endoplasmic reticulum is a focus of risk factors for early‐ and late‐onset Alzheimer’s diseaseDatta D, Mentone S, Morozov Y, van Dyck C, Arnsten A. The calcium‐containing smooth endoplasmic reticulum is a focus of risk factors for early‐ and late‐onset Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.047651.
  • Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal MigrationMorozov YM, Mackie K, Rakic P. Cannabinoid Type 1 Receptor is Undetectable in Rodent and Primate Cerebral Neural Stem Cells but Participates in Radial Neuronal Migration International Journal Of Molecular Sciences 2020, 21: 8657. PMID: 33212822, PMCID: PMC7696736, DOI: 10.3390/ijms21228657.
  • Neuron-Glia Inflammatory Interactions in Aging Rhesus Macaque Dorsolateral Prefrontal Cortex Layer IIIDatta D, Morozov Y, Arnsten A. Neuron-Glia Inflammatory Interactions in Aging Rhesus Macaque Dorsolateral Prefrontal Cortex Layer III Biological Psychiatry 2020, 87: s425. DOI: 10.1016/j.biopsych.2020.02.1084.
  • P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOADDatta D, Morozov Y, Arellano J, Dyck C, Arnsten A. P4‐143: LOSS OF PDE4D REGULATION OF CAMP‐PKA‐CALCIUM SIGNALING IN THE AGING ASSOCIATION CORTEX: INCREASING RISK FOR LOAD Alzheimer's & Dementia 2019, 15: p1329-p1329. DOI: 10.1016/j.jalz.2019.06.3804.
  • F164. Ultrastructural Localization of Classical Complement Cascade Signaling Protein C1q in Rhesus Macaque Dorsolateral Prefrontal CortexDatta D, Morozov Y, van Dyck C, Arnsten A. F164. Ultrastructural Localization of Classical Complement Cascade Signaling Protein C1q in Rhesus Macaque Dorsolateral Prefrontal Cortex Biological Psychiatry 2019, 85: s276-s277. DOI: 10.1016/j.biopsych.2019.03.701.
  • [O2–02–03]: ULTRASTRUCTURAL EVIDENCE FOR IMPAIRED MITOCHONDRIAL FISSION IN THE AGED RHESUS MONKEY DORSOLATERAL PREFRONTAL CORTEX: RELEVANCE TO THE PATHOGENESIS OF ALZHEIMER's DISEASEDatta D, Morozov Y, Paspalas A. [O2–02–03]: ULTRASTRUCTURAL EVIDENCE FOR IMPAIRED MITOCHONDRIAL FISSION IN THE AGED RHESUS MONKEY DORSOLATERAL PREFRONTAL CORTEX: RELEVANCE TO THE PATHOGENESIS OF ALZHEIMER's DISEASE Alzheimer's & Dementia 2017, 13: p553-p553. DOI: 10.1016/j.jalz.2017.07.151.
  • M97. Impairments in Mitochondrial Fission in Rhesus Monkey Dorsolateral Prefrontal Cortex: Ultrastructural Evidence for a Novel Cellular Mechanism of AgingDatta D, Morozov Y. M97. Impairments in Mitochondrial Fission in Rhesus Monkey Dorsolateral Prefrontal Cortex: Ultrastructural Evidence for a Novel Cellular Mechanism of Aging Schizophrenia Bulletin 2017, 43: s246-s246. PMCID: PMC5475857, DOI: 10.1093/schbul/sbx022.092.
  • Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleusMorozov YM, Koch M, Rakic P, Horvath TL. Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus Molecular Metabolism 2017, 6: 374-381. PMID: 28377876, PMCID: PMC5369208, DOI: 10.1016/j.molmet.2017.01.004.
  • Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortexMorozov YM, Datta D, Paspalas CD, Arnsten AF. Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex Neurobiology Of Aging 2016, 51: 9-18. PMID: 28027494, PMCID: PMC5292282, DOI: 10.1016/j.neurobiolaging.2016.12.001.
  • Novel insights into central regulation of food intakeKoch M, Elmquist J, Morozov Y, Rakic P, Bechmann I, Cowley M, Dietrich M, Diano S, Horvath T. Novel insights into central regulation of food intake Neuropeptides 2016, 55: 30. DOI: 10.1016/j.npep.2015.11.086.
  • Alteration of SLP2‐like immunolabeling in mitochondria signifies early cellular damage in developing and adult mouse brainMorozov YM, Sun YY, Kuan CY, Rakic P. Alteration of SLP2‐like immunolabeling in mitochondria signifies early cellular damage in developing and adult mouse brain European Journal Of Neuroscience 2015, 43: 245-257. PMID: 26547131, PMCID: PMC4784115, DOI: 10.1111/ejn.13124.
  • Antibodies to cannabinoid type 1 receptor co‐react with stomatin‐like protein 2 in mouse brain mitochondriaMorozov YM, Dominguez MH, Varela L, Shanabrough M, Koch M, Horvath TL, Rakic P. Antibodies to cannabinoid type 1 receptor co‐react with stomatin‐like protein 2 in mouse brain mitochondria European Journal Of Neuroscience 2013, 38: 2341-2348. PMID: 23617247, PMCID: PMC3902808, DOI: 10.1111/ejn.12237.
  • Origin, Early Commitment, Migratory Routes, and Destination of Cannabinoid Type 1 Receptor-Containing InterneuronsMorozov YM, Torii M, Rakic P. Origin, Early Commitment, Migratory Routes, and Destination of Cannabinoid Type 1 Receptor-Containing Interneurons Cerebral Cortex 2009, 19: i78-i89. PMID: 19346272, PMCID: PMC3584650, DOI: 10.1093/cercor/bhp028.
  • Hardwiring the Brain: Endocannabinoids Shape Neuronal ConnectivityBerghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urbán G, Monory K, Marsicano G, Matteoli M, Canty A, Irving AJ, Katona I, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T. Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity Science 2007, 316: 1212-1216. PMID: 17525344, DOI: 10.1126/science.1137406.
  • Translocation of Synaptically Connected Interneurons across the Dentate Gyrus of the Early Postnatal Rat HippocampusMorozov YM, Ayoub AE, Rakic P. Translocation of Synaptically Connected Interneurons across the Dentate Gyrus of the Early Postnatal Rat Hippocampus Journal Of Neuroscience 2006, 26: 5017-5027. PMID: 16687493, PMCID: PMC6674251, DOI: 10.1523/jneurosci.0272-06.2006.
  • Postnatal development and migration of cholecystokinin-immunoreactive interneurons in rat hippocampusMorozov Y, Freund T. Postnatal development and migration of cholecystokinin-immunoreactive interneurons in rat hippocampus Neuroscience 2003, 120: 923-939. PMID: 12927199, DOI: 10.1016/s0306-4522(03)00409-3.
Edit Profile