Nicholas Carnevale, MD/PhD
Cards
Appointments
Contact Info
About
Titles
Senior Research Scientist in Neuroscience
Appointments
Neuroscience
Senior Research ScientistPrimary
Other Departments & Organizations
- Neuroscience
- Shepherd Lab
Education & Training
- Resident
- Stanford University Hospital (1978)
- Intern
- University of California, San Diego (1975)
- MD/PhD
- Duke University (1974)
- BS
- University of Arizona (1968)
Research
Overview
Some of my recent accomplishments and ongoing projects include:
* Developing a theoretical basis for predicting the outcome of a proposed cellular mechanism of learning. Tsai, K.Y., Carnevale, N.T., and Brown, T.H. Hebbian learning is jointly controlled by electrotonic and input structure. Network 5:1-19, 1994.
* Creating and applying new approaches to the analysis and understanding of electrical signaling in real neurons.
One example is the electrotonic transformation, an intuitive, empirically-based method for deriving insight to the functional consequences of neuronal anatomy and biophysical properties.
Most recently we have applied the transformation to the study of the principal neurons in the rat hippocampus, and extended its use to the interpretation of electrotonic architecture in the context of the circuitry in which neurons are embedded
Tsai, K.Y., Carnevale, N.T., Claiborne, B.J., and Brown, T.H. Efficient mapping from neuroanatomical to electrotonic space. Network 5:21-46, 1994.
Carnevale, N.T., Tsai, K.Y., Claiborne, B.J., and Brown, T.H. The electrotonic transformation: a tool for relating neuronal form to function. In: Advances in Neural Information Processing Systems, vol. 7, edited by Tesauro, G., Touretzky, D.S., and Leen, T.K. Cambridge, MA, MIT Press, 1995, p. 69-76. Preprint viewable and downloadable.
O'Boyle, M.P., Carnevale, N.T., Claiborne, B.J., and Brown, T.H. A new graphical approach for visualizing the relationship between anatomical and electrotonic structure. In: Computational Neuroscience: Trends in Research 1995, edited by J.M. Bower. San Diego: Academic Press, 1996, p. 423-428. Preprint available.
Carnevale, N.T., Tsai, K.Y., Claiborne, B.J., and Brown, T.H. Comparative electrotonic analysis of three classes of rat hippocampal neurons. J. Neurophysiol. 78:703-720, 1997.
Carnevale, N.T., O'Boyle, M.P., and Claiborne, B.J. Dendritic branching compensates for synaptic attenuation in granule cells of the rat dentate gyrus. Neuroscience Society Abstracts 24:1814, 1998.
* Collaborating with Michael Hines and John Moore in the support and enhancement of NEURON:
One practical outcome of this collaboration has been porting this sophisticated simulation environment from UNIX / Xwindows to MS-Windows and the Macintosh.
This put the leading software package for empirically-based modeling of individual neurons and networks of neurons within reach of everyone who is engaged in neuroscience research and teaching.
Hines, M. and Carnevale, N.T. Computer modeling methods for neurons. In: The Handbook of Brain Theory and Neural Networks, edited by M.A. Arbib. Cambridge, MA: MIT Press, 1995, p. 226-230. Preprint available as arbib.ps.Z, (a compressed PostScript file for ghostview) and arbib.zip (a pkzipped pdf file for Adobe Acrobat).
Carnevale, N.T., Tsai, K.Y., and Hines, M.L. The Electrotonic Workbench Neuroscience Society Abstracts 22:1741, 1996. Poster viewable in HTML format. Hines, M.L. and Carnevale, N.T. The NEURON simulation environment. Neural Computation 9:1179-1209, 1997. Preprint viewable and downloadable.
* Producing and directing short courses on NEURON that have been presented at Yale, annual meetings of the Society for Neuroscience, and the San Diego Supercomputer Center. Plans are now under way for future offerings of these courses plus new courses on related topics--see http://www.neuron.yale.edu/neuron/courses.html
* Developing new courses for undergraduate and graduate students that use simulation exercises implemented with NEURON to facilitate learning the physiology of excitable cells (see http://www.neuron.yale.edu/neuron/edu/nrnlab.htm and http://www.neuron.yale.edu/neuron/classes/445b/announce.htm ).
* A project to create a published set of laboratory simulation exercises, with an accompanying manual, that will advance neuroscience education by providing an intensive, interactive exploration of the processes that underlie neuronal function. More information about this NSF-supported collaboration with David Jaffe and Michael Hines is posted at http://www.neuron.yale.edu/neuron/edu/nrnlab.htm
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Michael Hines, PhD
Membrane Potentials
Publications
2024
Expression of model ion channel currents generated using neuron in silico software in real time using dynamic clamp
Acharya S, Panama B, Korbel L, Nilsson L, Hines M, Carnevale N, Bett G, Rasmusson R, Nowak M. Expression of model ion channel currents generated using neuron in silico software in real time using dynamic clamp. Biophysical Journal 2024, 123: 532a-533a. DOI: 10.1016/j.bpj.2023.11.3218.Peer-Reviewed Original Research
2023
Input of expressed hERG current into a complex neuron in silico cardiac atrial cell: Implications for cardiotoxicity screening
Nowak M, Korbel L, Kane A, Panama B, Hines M, Carnevale N, Bett G, Rasmusson R. Input of expressed hERG current into a complex neuron in silico cardiac atrial cell: Implications for cardiotoxicity screening. Biophysical Journal 2023, 122: 382a. DOI: 10.1016/j.bpj.2022.11.2097.Peer-Reviewed Original Research
2022
Interfacing a real-time dynamic clamp system with neuron simulation software in living cells
Nowak M, Korbel L, Kane A, Panama B, Hines M, Carnevale N, Bett G, Rasmusson R. Interfacing a real-time dynamic clamp system with neuron simulation software in living cells. Biophysical Journal 2022, 121: 391a. DOI: 10.1016/j.bpj.2021.11.818.Peer-Reviewed Original Research
2019
Web of Trust Tool for Gateway User Vetting
Yoshimoto K, Carnevale N, Sivagnanam S, Majumdar A, Miller M. Web of Trust Tool for Gateway User Vetting. 2019, 1-5. DOI: 10.1145/3332186.3332221.Peer-Reviewed Original Research
2018
The Neuroscience Gateway
Sivagnanam S, Yoshimoto K, Carnevale N, Majumdar A. The Neuroscience Gateway. 2018, 1-7. DOI: 10.1145/3219104.3219139.Peer-Reviewed Original ResearchCitationsConceptsNeuroscience GatewayProgrammatic accessComputational neuroscientistsFront-end user interfaceEuropean Human Brain ProjectEnd-user interfaceHuman Brain ProjectGateway softwareHPC resourcesUser interfaceNeuroscience communityBackend architectureExtreme ScienceDissemination platformBrain ProjectUsage modesExperimental neuroscientistsUsersCompetitive peer review processHigh performanceGatewayArchitectureNeuroscience projectsWebResources
2008
Functional Structure of the Mitral Cell Dendritic Tuft in the Rat Olfactory Bulb
Djurisic M, Popovic M, Carnevale N, Zecevic D. Functional Structure of the Mitral Cell Dendritic Tuft in the Rat Olfactory Bulb. Journal Of Neuroscience 2008, 28: 4057-4068. PMID: 18400905, PMCID: PMC6670455, DOI: 10.1523/jneurosci.5296-07.2008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMitral cellsDendritic tuftsOlfactory bulbGlomerular tuftPrincipal projection neuronsVoltage-sensitive dye recordingRat olfactory bulbSubthreshold synaptic potentialsPrimary dendritesProjection neuronsSynaptic potentialsSame neuronsEPSPsElectrical compartmentsDendritic branchesAnatomical studySynchronized activationDendritic surfaceNeuronsSynapsesCell typesAverage rangePassive electrical propertiesCellsTufts2 The Neuron Simulation Environment in Epilepsy Research
Carnevale N, Hines M. 2 The Neuron Simulation Environment in Epilepsy Research. 2008, 18-33. DOI: 10.1016/b978-012373649-9.50005-3.Peer-Reviewed Original ResearchCitationsConceptsLigand-dependent ion channelsIon accumulationExtracellular ion accumulationIon channelsCell membraneSingle cellsBiophysical propertiesBiophysical mechanismsSubcellular mechanismsExtracellular stimulationMechanistic modelStochastic gatingElectrical fieldCellsDomainAccumulationBiologyNeuronsMechanismChemical reactionsLocal concentrationSpecial programming languageComputational detailsMembraneIndividual neurons
2006
The NEURON Book
Carnevale N, Hines M. The NEURON Book. 2006 DOI: 10.1017/cbo9780511541612.Peer-Reviewed Original ResearchCitationsAltmetric
2004
ModelDB: A Database to Support Computational Neuroscience
Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM. ModelDB: A Database to Support Computational Neuroscience. Journal Of Computational Neuroscience 2004, 17: 7-11. PMID: 15218350, PMCID: PMC3732827, DOI: 10.1023/b:jcns.0000023869.22017.2e.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsDiscrete event simulation in the NEURON environment
Hines M, Carnevale N. Discrete event simulation in the NEURON environment. Neurocomputing 2004, 58: 1117-1122. DOI: 10.1016/j.neucom.2004.01.175.Peer-Reviewed Original ResearchCitations