Stavroula Hatzios, PhD
she/her/hers
Assistant Professor of Molecular, Cellular and Developmental Biology and of Chemistry
Research & Publications
Biography
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Research Summary
Molecular interactions between bacterial and host cells can profoundly impact human health and disease. We study enzymes and other proteins whose biochemical activity dynamically shapes these interactions in the context of gastrointestinal infections. We use a diverse set of chemical and biological tools to address fundamental questions regarding biochemical crosstalk at the host-microbe interface: What enzymes are active during an infection? How does pathogen-associated stress (e.g., from the immune system or antimicrobials) influence protein function in infected cells? What molecular processes do these proteins regulate? By interrogating the functional proteome of bacterial infections, we aim to uncover biochemical pathways that will advance our understanding of gastrointestinal diseases like stomach cancer and cholera and generate new leads for therapeutic targets, activity-based diagnostics, and drug delivery systems.
Coauthors
Research Interests
Bacteria; Biochemistry; Enzyme Activation; Gastrointestinal Diseases; Microbiology; Host-Pathogen Interactions
Selected Publications
- Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection.Baskerville MJ, Kovalyova Y, Mejías-Luque R, Gerhard M, Hatzios SK. Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection. PLoS Pathog 2023, 19: e1011526. PMID: 37494402, DOI: 10.1371/journal.ppat.1011526.
- Moonlighting in the membraneHatzios S. Moonlighting in the membrane Nature Chemical Biology 2023, 1-2. PMID: 37349584, DOI: 10.1038/s41589-023-01369-4.
- Emerging roles of low-molecular-weight thiols at the host–microbe interfaceDumitrescu D, Hatzios S. Emerging roles of low-molecular-weight thiols at the host–microbe interface Current Opinion In Chemical Biology 2023, 75: 102322. PMID: 37201290, DOI: 10.1016/j.cbpa.2023.102322.
- Activity‐based Tools for Interrogating Host Biology During InfectionRamanathan R, Hatzios S. Activity‐based Tools for Interrogating Host Biology During Infection Israel Journal Of Chemistry 2023, 63 DOI: 10.1002/ijch.202200095.
- A microbial transporter of the dietary antioxidant ergothioneineDumitrescu D, Gordon E, Kovalyova Y, Seminara A, Duncan-Lowey B, Forster E, Zhou W, Booth C, Shen A, Kranzusch P, Hatzios S. A microbial transporter of the dietary antioxidant ergothioneine Cell 2022, 185: 4526-4540.e18. PMID: 36347253, PMCID: PMC9691600, DOI: 10.1016/j.cell.2022.10.008.
- A propeptide-based biosensor for the selective detection of Vibrio cholerae using an environment-sensitive fluorophoreDeColli AA, Koolik IM, Seminara AB, Hatzios SK. A propeptide-based biosensor for the selective detection of Vibrio cholerae using an environment-sensitive fluorophore Cell Chemical Biology 2022, 29: 1505-1516.e7. PMID: 36270233, DOI: 10.1016/j.chembiol.2022.09.003.
- An infection-induced oxidation site regulates legumain processing and tumor growthKovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK. An infection-induced oxidation site regulates legumain processing and tumor growth Nature Chemical Biology 2022, 18: 698-705. PMID: 35332331, PMCID: PMC9246868, DOI: 10.1038/s41589-022-00992-x.
- Chemical tools for decoding redox signaling at the host–microbe interfaceGordon EM, Hatzios SK. Chemical tools for decoding redox signaling at the host–microbe interface PLOS Pathogens 2020, 16: e1009070. PMID: 33332456, PMCID: PMC7745962, DOI: 10.1371/journal.ppat.1009070.
- Functional characterization of a subtilisin-like serine protease from Vibrio choleraeHowell M, Dumitrescu DG, Blankenship LR, Herkert D, Hatzios SK. Functional characterization of a subtilisin-like serine protease from Vibrio cholerae Journal Of Biological Chemistry 2019, 294: 9888-9900. PMID: 31076508, PMCID: PMC6597830, DOI: 10.1074/jbc.ra119.007745.
- Activity-Based Protein Profiling at the Host–Pathogen InterfaceKovalyova Y, Hatzios SK. Activity-Based Protein Profiling at the Host–Pathogen Interface 2018, 420: 73-91. PMID: 30203396, DOI: 10.1007/82_2018_129.
- Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and DiseaseStockwell BR, Angeli J, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease Cell 2017, 171: 273-285. PMID: 28985560, PMCID: PMC5685180, DOI: 10.1016/j.cell.2017.09.021.
- Chemoproteomic profiling of host and pathogen enzymes active in choleraHatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Chemoproteomic profiling of host and pathogen enzymes active in cholera Nature Chemical Biology 2016, 12: 268-274. PMID: 26900865, PMCID: PMC4765928, DOI: 10.1038/nchembio.2025.
- Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinaseHatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi CR. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: e5069-e5077. PMID: 24309377, PMCID: PMC3876250, DOI: 10.1073/pnas.1321205110.