Carmen Jane Booth, DVM, PhD
Assistant Professor of Comparative Medicine; Director, Comparative Pathology Research, Comparative Medicine
Research & Publications
Biography
News
Research Summary
- Collaborative research in primarily mouse developmental and research pathology with investigators within and outside Yale University School of Medicine.
- Hemophilia A in WAG/RijYcb Rats.
Specialized Terms: Pathology of genetically engineered mice; Pathology of inflammation; Pathology of aging; Veterinary Pathology; Mouse pathology; phenotyping; Hemophilia in rats
Coauthors
Selected Publications
- Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen BorreliaTang X, Cao Y, Booth C, Arora G, Cui Y, Matias J, Fikrig E. Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia. PLOS Biology 2023, 21: e3002331. PMID: 37862360, PMCID: PMC10619873, DOI: 10.1371/journal.pbio.3002331.
- Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosisMooring M, Yeung G, Luukkonen P, Liu S, Akbar M, Zhang G, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky M, Booth C, Konnikova L, Shulman G, Yimlamai D. Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis. Science Translational Medicine 2023, 15: eade3157. PMID: 37756381, PMCID: PMC10874639, DOI: 10.1126/scitranslmed.ade3157.
- Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigensFang Z, Monteiro V, Renauer P, Shang X, Suzuki K, Ling X, Bai M, Xiang Y, Levchenko A, Booth C, Lucas C, Chen S. Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens. Cell Research 2023, 33: 407-410. PMID: 36879038, PMCID: PMC9988199, DOI: 10.1038/s41422-023-00792-5.
- Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick FeedingNarasimhan S, Booth C, Philipp M, Fikrig E, Embers M. Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding. Pathogens 2023, 12: 132. PMID: 36678479, PMCID: PMC9861725, DOI: 10.3390/pathogens12010132.
- A microbial transporter of the dietary antioxidant ergothioneineDumitrescu D, Gordon E, Kovalyova Y, Seminara A, Duncan-Lowey B, Forster E, Zhou W, Booth C, Shen A, Kranzusch P, Hatzios S. A microbial transporter of the dietary antioxidant ergothioneine. Cell 2022, 185: 4526-4540.e18. PMID: 36347253, PMCID: PMC9691600, DOI: 10.1016/j.cell.2022.10.008.
- KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelementsZhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.
- Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in miceRyu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. ELife 2021, 10: e66522. PMID: 34151773, PMCID: PMC8245129, DOI: 10.7554/elife.66522.
- Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouseThomson R, Dynia DW, Burlein S, Thomson BR, Booth C, Knauf F, Wang T, Aronson P. Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse. American Journal Of Physiology. Renal Physiology 2021, 320: f1106-f1122. PMID: 33938239, PMCID: PMC8285649, DOI: 10.1152/ajprenal.00556.2020.
- PEGylated PLGA Nanoparticles for the Improved Delivery of DoxorubicinPark J, Fong P, Lu J, Russell K, Booth C, Mark Saltzman W, Fahmy T. PEGylated PLGA Nanoparticles for the Improved Delivery of Doxorubicin. 2017, 575-596. DOI: 10.1201/b22358-23.
- PEGylated PLGA Nanoparticles for the Improved Delivery of DoxorubicinPark J, Fong P, Lu J, Russell K, Booth C, Saltzman W, Fahmy T. PEGylated PLGA Nanoparticles for the Improved Delivery of Doxorubicin. 2017, 575-596. DOI: 10.1201/9781315114361-23.
- Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical TrialMonahan PE, Sun J, Gui T, Hu G, Hannah WB, Wichlan DG, Wu Z, Grieger JC, Li C, Suwanmanee T, Stafford DW, Booth CJ, Samulski JJ, Kafri T, McPhee SW, Samulski RJ. Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial. Human Gene Therapy 2015, 26: 69-81. PMID: 25419787, PMCID: PMC4326268, DOI: 10.1089/hum.2014.106.
- Epithelial (E)-Cadherin Is a Novel Regulator of Platelet FunctionKrause D, Halene S, Booth C, Jin H, Zou S, Teixeira A, Zhang P. Epithelial (E)-Cadherin Is a Novel Regulator of Platelet Function. Blood 2014, 124: 95. DOI: 10.1182/blood.v124.21.95.95.
- Proteomics Identify Haptoglobin as a Novel Enhancer of Cardiac Transplant Rejection.Goldstein D, Heuzey E, Mori D, Colangelo C, Chung L, Bruce C, Booth C, Kreisel D, Shen H. Proteomics Identify Haptoglobin as a Novel Enhancer of Cardiac Transplant Rejection. Transplantation 2014, 98: 885. DOI: 10.1097/00007890-201407151-03021.
- (432) Discovering Novel Inflammatory Triggers after Heart Transplantation Via ProteomicsShen H, Colangelo C, Chung L, Bruce C, Booth C, Kreisel D, Goldstein D. (432) Discovering Novel Inflammatory Triggers after Heart Transplantation Via Proteomics. The Journal Of Heart And Lung Transplantation 2014, 33: s164. DOI: 10.1016/j.healun.2014.01.439.
- Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell LymphomagenesisGu X, Booth C, Liu Z, Strout M. Activation Induced Cytidine Deaminase-Associated DNA Repair Pathways Influence Germinal Center B Cell Lymphomagenesis. Blood 2013, 122: 1247. DOI: 10.1182/blood.v122.21.1247.1247.
- The Role of DNA Repair in the Pathogenesis of Activation Induced Cytidine Deaminase Dependent B Cell LymphomaGu X, Booth C, Schatz D, Strout M. The Role of DNA Repair in the Pathogenesis of Activation Induced Cytidine Deaminase Dependent B Cell Lymphoma. Blood 2011, 118: 397. DOI: 10.1182/blood.v118.21.397.397.
- Corrections: Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm LaborCardenas I, Means R, Aldo P, Koga K, Lang S, Booth C, Manzur A, Oyarzun E, Romero R, Mor G. Corrections: Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor. The Journal Of Immunology 2011, 187: 2835-2835. DOI: 10.4049/jimmunol.1190048.
- Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm LaborCardenas I, Means RE, Aldo P, Koga K, Lang SM, Booth C, Manzur A, Oyarzun E, Romero R, Mor G. Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor. The Journal Of Immunology 2010, 185: 1248-1257. PMID: 20554966, PMCID: PMC3041595, DOI: 10.4049/jimmunol.1000289.
- Evaluation of hepatic fibrosis with portal pressure gradient in ratsWang Y, Booth CJ, Kim H, Qiu M, Constable RT. Evaluation of hepatic fibrosis with portal pressure gradient in rats. Magnetic Resonance In Medicine 2009, 61: 1185-1192. PMID: 19253377, DOI: 10.1002/mrm.21964.
- Induced Hepatic Fibrosis in Rats: Hepatic Steatosis, Macromolecule Content, Perfusion Parameters, and Their Correlations—Preliminary MR Imaging in RatsKim H, Booth CJ, Pinus AB, Chen P, Lee A, Qiu M, Whitlock M, Murphy PS, Constable RT. Induced Hepatic Fibrosis in Rats: Hepatic Steatosis, Macromolecule Content, Perfusion Parameters, and Their Correlations—Preliminary MR Imaging in Rats. Radiology 2008, 247: 696-705. PMID: 18403622, DOI: 10.1148/radiol.2473070605.
- Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibitionRavishankar V, Buhimschi CS, Booth CJ, Bhandari V, Norwitz E, Copel J, Buhimschi IA. Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition. American Journal Of Obstetrics And Gynecology 2007, 196: 482.e1-482.e8. PMID: 17466713, DOI: 10.1016/j.ajog.2006.12.020.
- Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosisEswarakumar VP, Özcan F, Lew ED, Bae JH, Tomé F, Booth CJ, Adams DJ, Lax I, Schlessinger J. Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 18603-18608. PMID: 17132737, PMCID: PMC1693709, DOI: 10.1073/pnas.0609157103.
- Fetal nucleated red blood cells (NRBC) are regulated independently of erythropoietin levels in a rat model of intrauterine growth restriction (IUGR)Ravishankar V, Buhimschi C, Booth C, Bhandari V, Norwitz E, Copel J, Buhimschi I. Fetal nucleated red blood cells (NRBC) are regulated independently of erythropoietin levels in a rat model of intrauterine growth restriction (IUGR). American Journal Of Obstetrics And Gynecology 2006, 195: s10. DOI: 10.1016/j.ajog.2006.10.030.
- Recruitment of Macrophages and Polymorphonuclear Leukocytes in Lyme Carditis▿Montgomery RR, Booth CJ, Wang X, Blaho VA, Malawista SE, Brown CR. Recruitment of Macrophages and Polymorphonuclear Leukocytes in Lyme Carditis▿. Infection And Immunity 2006, 75: 613-620. PMID: 17101663, PMCID: PMC1828503, DOI: 10.1128/iai.00685-06.
- The utility of circulating nucleated red blood cells (NRBC) in predicting chronic hypoxia in a rat model of intrauterine growth restriction (IUGR)Viswanathan R, Norwitz E, Buhimschi C, Booth C, Copel J, Buhimschi I. The utility of circulating nucleated red blood cells (NRBC) in predicting chronic hypoxia in a rat model of intrauterine growth restriction (IUGR). American Journal Of Obstetrics And Gynecology 2004, 191: s32. DOI: 10.1016/j.ajog.2004.09.108.
- Oxidative stress and intrauterine growth restriction (IUGR): A selective inability of the fetus to respond to an oxidative insultRavishankar V, Norwitz E, Buhimschi C, Booth C, Copel J, Buhimschi I. Oxidative stress and intrauterine growth restriction (IUGR): A selective inability of the fetus to respond to an oxidative insult. American Journal Of Obstetrics And Gynecology 2004, 191: s140. DOI: 10.1016/j.ajog.2004.10.391.