Mateus Guerra, PhD
Cards
About
Research
Publications
2024
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis
Ogino N, Leite M, Guerra M, Kruglov E, Asashima H, Hafler D, Ito T, Pereira J, Peiffer B, Sun Z, Ehrlich B, Nathanson M. Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis. Journal Of Clinical Investigation 2024 PMID: 38916955, DOI: 10.1172/jci171691.Peer-Reviewed Original ResearchAlcohol-associated hepatitisReduced cell proliferationCalcium channel expressionCalcium signaling mechanismsIntracellular calcium channelsCell proliferationRegulate calcium signalingNeutrophil extracellular trapsChannel expressionNeutrophil granule proteinsCalcium channelsNeutrophil infiltrationPatient specimensGranule proteasesMouse modelHealthy subjectsLiver diseaseExtracellular trapsCalcium signalingSerpin E2NeutrophilsElastase activityHepatitisTissue remodelingSignaling mechanisms
2023
1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo
LAMOIA T, HUBBARD B, GUERRA M, GOODMAN R, NATHANSON M, SHULMAN G. 1558-P: The Mitochondrial Calcium Uniporter Regulates Hepatic Mitochondrial Oxidation and Intracellular Redox In Vivo. Diabetes 2023, 72 DOI: 10.2337/db23-1558-p.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseHepatic mitochondrial oxidationMitochondrial calcium uniporterHepatocellular redox stateFatty liver diseaseEctopic lipid accumulationType 2 diabetesHepatic lipid contentNovel therapeutic targetMitochondrial oxidationHepatic triacylglycerol contentMitochondrial calcium influxMitochondrial redox ratioMitochondrial calciumKnockout mouse modelFortress BiotechMitochondrial fat oxidationNonalcoholic steatohepatitisLiver diseaseWT miceKO miceMetabolic dysfunctionCalcium uniporterCalcium influxMouse modelAbove the legal limit: Alcohol brings ER and mitochondria too close together
Guerra M, Nathanson M. Above the legal limit: Alcohol brings ER and mitochondria too close together. Cell Calcium 2023, 113: 102763. PMID: 37235972, PMCID: PMC10726477, DOI: 10.1016/j.ceca.2023.102763.Commentaries, Editorials and LettersMitochondrial calcium signaling in cholangiocarcinoma
Loyola-Machado A, Guerra M, Nathanson M. Mitochondrial calcium signaling in cholangiocarcinoma. Hepatoma Research 2023, 9: null-null. DOI: 10.20517/2394-5079.2023.28.Peer-Reviewed Original ResearchPrimary liver cancerNew pharmacological agentsPathogenesis of cholangiocarcinomaMitochondrial Ca2Liver cancerCholangiocarcinomaPharmacological agentsIntracellular Ca2Molecular alterationsDruggable targetsER-mitochondrial contact sitesCancer cellsKey regulatory moleculesMetabolic reprogramingReceptor familyMitochondrial healthMitochondrial calciumEnergy metabolismCell deathPathways of interestLatest findingsTreatmentCa2Regulatory moleculesContact sites
2020
Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tract
Lemos F, Guerra M, de Fátima Leite M. Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tract. Current Opinion In Physiology 2020, 17: 169-174. DOI: 10.1016/j.cophys.2020.08.003.Peer-Reviewed Original ResearchEpithelial cellsFatty liver diseaseIntracellular calcium signalingLiver diseaseAcute pancreatitisSecretory epithelial cellsPathophysiological roleGastrointestinal tractElectrolyte secretionSolid tumorsIntracellular Ca2Main intracellular Ca2Number of diseasesDiseaseCell proliferationCalcium signalingEnergy metabolismReceptorsMolecular mechanismsSubcellular localizationTrisphosphate receptorPhysiological functionsCellsInositol 1Ca2Ca2+ Signaling in the Liver
Guerra M, Leite M, Nathanson M. Ca2+ Signaling in the Liver. 2020, 496-508. DOI: 10.1002/9781119436812.ch40.ChaptersBile duct epitheliumDuct epitheliumNon-alcoholic fatty liver diseaseBile acid-independent bile flowBile acid-dependent flowFatty liver diseaseLiver diseaseBile flowElectrolyte secretionLipid metabolismGrowth factorLiverCell populationsRat liverVariety of mechanismsEpitheliumCa2Recent studiesCell cycleHepatocytesLesser extentPathogenesisDiseaseNeurotransmittersHormone
2015
Signaling pathways in biliary epithelial cells
Leite M, Guerra M, Andrade V, Nathanson M. Signaling pathways in biliary epithelial cells. 2015, 15-33. DOI: 10.1002/9781118663387.ch2.Peer-Reviewed Original ResearchBiliary epithelial cellsEpithelial cellsFormation of bileSurface membrane receptorsBiliary treeDuctal bileIntracellular signal transduction pathwaysCanalicular bileGrowth factorCholangiocytesBileCell functionPeptide hormonesBile saltsDetoxification of xenobioticsMembrane receptorsSignal transduction pathwaysTransduction pathwaysSignaling pathways in biliary epithelial cells
Leite Mde, F., et al. (2015). Signaling Pathways in Liver Diseases. J. F. Dufour and P. A. Clavien, Wiley-Blackwell: 520.Chapters
2009
Ca2+ Signaling in the Liver
Leite F, Guerra M, Nathanson M. Ca2+ Signaling in the Liver. 2009, 485-510. DOI: 10.1002/9780470747919.ch32.Chapters
2006
Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]
Marius P, Guerra M, Nathanson M, Ehrlich B, Leite M. Corrigendum to “Calcium release from ryanodine receptors in the nucleoplasmic reticulum” [Cell Calcium 39 (2006) 65–73]. Cell Calcium 2006, 39: 551. DOI: 10.1016/j.ceca.2006.02.001.Peer-Reviewed Original Research
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Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States