Research & Publications
The Lee lab develops and applies high-throughput genomic technologies to interrogate the function of infiltrating immune cells in tumors and in autoimmune/alloimmune patient specimens. Work in the lab lies at the intersection of human immunology, immunogenetics, and functional genomics. The lab collaborates with physicians and partners with patients to collect primary samples; characterizes variation in immune genes using next-generation and single-cell sequencing; and uses a combination of high-throughput functional genomics, immunology, and molecular biology to interrogate gene and variant function down to the molecular level. Major goals of the lab include: uncovering the pathophysiology of autoimmune diseases by identifying self-reactive antigens, designing new T cell receptor-based therapies for cancer patients, and designing novel antigen-based therapies for patients with alloimmune diseases.
Antigenic Variation; Antigens; Autoimmune Diseases; Hematologic Diseases; Immune System Diseases; Immunologic Memory; Immunotherapy; Lymphocyte Activation; Major Histocompatibility Complex; Neoplasms; Neoplastic Processes; Pathology; Pathology, Clinical; Gene Rearrangement, T-Lymphocyte; Autoimmunity; Genomics; T-Cell Antigen Receptor Specificity; Adaptive Immunity; Immune Evasion; Tumor Microenvironment; Clonal Selection, Antigen-Mediated; Molecular Medicine; Biological Variation, Individual; Immune Checkpoint Inhibitors; Translational Science, Biomedical