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Lohith Gowda, MD, MRCP

Assistant Professor of Medicine (Hematology); Assistant Professor of Medicine (Hematology), Internal Medicine

Contact Information

Lohith Gowda, MD, MRCP

Research Summary

Bone marrow origin blood cancers and immune deficiencies are a complex set of medical conditions that need both pharmacologic and cellular therapies. My prior work in the laboratory has identified key therapeutic targets that can be advanced to clinical trials in the field of myeloid neoplasms. Working closely with other providers at Yale we offer both investigator initiated and industry sponsored clinical trials for patients with hematologic neoplasms needing transplantation or cellular immunotherapy (CAR-T, and other effector immune cells). My group also leads large international registry level research to identify barriers to curative intent cellular therapies and identify limitations and success with its application across different disease spectrum.

Extensive Research Description

Targeted therapy; Transfusion Associated Immunomodulation, Immunotherapy, Cellular Therapy, Regenerative Medicine

Coauthors

Research Interests

Anemia, Aplastic; Blood Transfusion; Bone Marrow Diseases; Immunotherapy; Leukemia; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Hematopoietic Stem Cell Transplantation; Primary Myelofibrosis

Selected Publications

Clinical Trials

ConditionsStudy Title
LungAn Open-Label, Multi-Centre Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T Cells in Patients With Advanced Non-Small Cell Lung Cancer
Leukemia, otherA Phase 2 Study of Donor-Derived Multi-Tumor-Associated Antigen Specific T Cells (MT-401) Administered to Patients With Acute Myeloid Leukemia (AML) Following Hematopoietic Stem Cell Transplantation
Non-Hodgkin's LymphomaA Phase 1, Open-Label, Multicenter, Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Anti-CD70 Allogeneic CRISPR-Cas9-Engineered T Cells (CTX130) in Subjects With Relapsed or Refractory T or B Cell Malignancies
Non-Hodgkin's LymphomaA Multi-center Single Arm Phase II Study to Evaluate the Safety and Efficacy of Genetically Engineered Autologous Cells Expressing Anti-CD20 and Anti-CD19 Specific Chimeric Antigen Receptor in Subjects With Relapsed and/or Refractory Diffuse Large B Cell Lymphoma
Hodgkin's LymphomaA Phase 2, Single-arm, Multi-center Trial to Determine the Efficacy and Safety of JCAR017 in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma or With Other Aggressive B-Cell Malignancies
Hodgkin's Lymphoma; Lymphoid Leukemia; Non-Hodgkin's LymphomaManaged Access Program (MAP) to Provide Access to CTL019, for ALL or DLBCL Patients With Out of Specification Leukapheresis Product and/or Manufactured Tisagenlecleucel Out of Specification for Commercial Release
Hodgkin's Lymphoma; Leukemia, not otherwise specified; Leukemia, other; Lymphoid Leukemia; Mycosis Fungoides; Myeloid and Monocytic Leukemia; Non-Hodgkin's Lymphoma; Other Hematopoietic; Supportive CarePhase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym-M (ALVR105) for the Treatment of Patients With Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant (HCT)