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Nikolai Podoltsev, MD, PhD

Associate Professor of Internal Medicine (Hematology); Duffy Firm Chief for Education, Department of Internal Medicine; Associate Director of the Hematology/Oncology Fellowship Program

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Nikolai Podoltsev, MD, PhD

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Research Summary

My research interests include management of malignant hematology conditions such as acute leukemias (focus on treatment of adults with ALL and AML patients with FLT-3 mutations), myelodysplastic syndromes (MDS) and myeloprolipherative neoplasms (MPN) as well as bone marrow failure (aplastic anemia) and clonal hematopoiesis of indeterminate potential (CHIP). I am currently serving as a Yale principle investigator for a number of clinical studies including industry-sponsored, cooperative group and investigator initiated trials looking at the efficacy of different novel agents for patients with malignant hematological conditions who otherwise have limited treatment options. I participate in hematology group of the Yale University Cancer Outcomes, Public Policy and Effectiveness Research (COPPER) Center to study myeloid neoplasms with special interest in MPN.

Extensive Research Description

Management of Malignant Hematology - Older Adult Focus; Myeloprolipherative Neoplasms

Coauthors

Research Interests

Leukemia; Myelodysplastic Syndromes; Myeloproliferative Disorders

Selected Publications

Clinical Trials

ConditionsStudy Title
Myeloid and Monocytic LeukemiaAn Open-Label Phase 1a/1b Dose Escalation and Expansion Cohort Study of SL-172154 (SIRPα-Fc-CD40L) in Combination With Azacitidine or With Azacitidine and Venetoclax for the Treatment of Subjects With Higher-Risk Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)
Myeloid and Monocytic LeukemiaBLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1 (BLAST MRD AML-1): A Randomized Phase 2 Study of the Anti-PD-1 Antibody Pembrolizumab in Combination With Conventional Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia
Multiple MyelomaA Phase 1, Open-label, Dose Finding Study of CC-93269, a BCMA X CD3 T Cell Engaging Antibody, in Subjects With Relapsed and Refractory Multiple Myeloma.
Leukemia, not otherwise specified; Leukemia, otherA Phase IB/II Study of Venetoclax (ABT-199) in Combination With Liposomal Vincristine in Patients With Relapsed or Refractory T-Cell or B-Cell Acute Lymphoblastic Leukemia
Leukemia, not otherwise specified; Leukemia, otherPhase II Study of Adding the Anti-PD-1 Pembrolizumab to Tyrosine Kinase Inhibitors in Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease
Myeloid and Monocytic LeukemiaThe National Myelodysplastic Syndromes Natural History Study
Leukemia, otherA Phase 1/2 Open Label, Multicenter, Dose Escalation and Expansion Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)
Other HematopoieticA Randomized, Double-blind, Placebo-controlled Phase 3 Study of Tamibarotene Plus Azacitidine Versus Placebo Plus Azacitidine in Newly Diagnosed, Adult Patients Selected for RARA-positive Higher-risk Myelodysplastic Syndrome (SELECT MDS-1)
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