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John D Murray, PhD

Associate Professor of Psychiatry

Research Summary

Research in the Murray Lab focuses on investigating the dynamics and function of neural circuits, and their dysfunction in psychiatric and neurological disorders. To investigate these issues, we develop modeling, theoretical, and data-analytic approaches to systems neuroscience, in close collaboration with experimentalists. We build biophysically-based neural circuit models that span levels of scale and complexity, ranging from detailed microcircuitry supporting cognitive function, to large-scale brain dynamics. Furthermore, we leverage computational insights from models to advance the study of disorders such as schizophrenia, in a framework for Computational Psychiatry.


Research Interests

Cognition; Computer Simulation; Decision Making; Interneurons; Memory, Short-Term; Schizophrenia; Prefrontal Cortex; Computational Biology; Functional Neuroimaging

Selected Publications

Clinical Trials

ConditionsStudy Title
Mental Health & Behavioral ResearchA Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia
Diseases of the Nervous System; Mental Health & Behavioral ResearchTeen Brain and Behavior Study
Diseases of the Nervous System; Mental Health & Behavioral ResearchBiomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder