John D Murray, PhD
Research & Publications
Biography
News
Research Summary
Research in the Murray Lab focuses on investigating the dynamics and function of neural circuits, and their dysfunction in psychiatric and neurological disorders. To investigate these issues, we develop modeling, theoretical, and data-analytic approaches to systems neuroscience, in close collaboration with experimentalists. We build biophysically-based neural circuit models that span levels of scale and complexity, ranging from detailed microcircuitry supporting cognitive function, to large-scale brain dynamics. Furthermore, we leverage computational insights from models to advance the study of disorders such as schizophrenia, in a framework for Computational Psychiatry.
Coauthors
Research Interests
Cognition; Computer Simulation; Decision Making; Interneurons; Memory, Short-Term; Schizophrenia; Prefrontal Cortex; Computational Biology; Functional Neuroimaging
Selected Publications
- Multitask representations in the human cortex transform along a sensory-to-motor hierarchyIto T, Murray J. Multitask representations in the human cortex transform along a sensory-to-motor hierarchy Nature Neuroscience 2022, 1-10. PMID: 36536240, DOI: 10.1038/s41593-022-01224-0.
- Towards mapping neuro-behavioral heterogeneity of psychedelic neurobiology in humansMoujaes F, Preller K, Ji J, Murray J, Berkovitch L, Vollenweider F, Anticevic A. Towards mapping neuro-behavioral heterogeneity of psychedelic neurobiology in humans Biological Psychiatry 2022 DOI: 10.1016/j.biopsych.2022.10.021.
- Geometry of neural computation unifies working memory and planningEhrlich DB, Murray JD. Geometry of neural computation unifies working memory and planning Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2115610119. PMID: 36067286, PMCID: PMC9478653, DOI: 10.1073/pnas.2115610119.
- Illness Phase as a Key Assessment and Intervention Window for PsychosisKohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Gur R, Gur R, Calkins M, D'Souza D, Srihari V, Gueorguieva R, Gueorguieva R, Patel P, Forselius-Bielen K, Forselius-Bielen K, Lu J, Butler A, Fram G, Fram G, Afriyie-Agyemang Y, Selloni A, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Abrahim P, Nia A, Nia A, Surti T, Surti T, Kegeles L, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Benedict E, Govil P, Govil P, Brazis S, Mayer M, Garrigue N, Fallon N, Fallon N, Baumvoll T, Abeykoon S, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T. Illness Phase as a Key Assessment and Intervention Window for Psychosis Biological Psychiatry Global Open Science 2022 DOI: 10.1016/j.bpsgos.2022.05.009.
- Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signalsCho YT, Moujaes F, Schleifer CH, Starc M, Ji JL, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal JH, Murray JD, Repovs G, Anticevic A. Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signals NeuroImage 2022, 254: 119139. PMID: 35346841, PMCID: PMC9264479, DOI: 10.1016/j.neuroimage.2022.119139.
- Transient neuronal suppression for exploitation of new sensory evidenceShinn M, Lee D, Murray JD, Seo H. Transient neuronal suppression for exploitation of new sensory evidence Nature Communications 2022, 13: 23. PMID: 35013222, PMCID: PMC8748884, DOI: 10.1038/s41467-021-27697-4.
- Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model.Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.
- Sensory-motor cortices shape functional connectivity dynamics in the human brainKong X, Kong R, Orban C, Wang P, Zhang S, Anderson K, Holmes A, Murray JD, Deco G, van den Heuvel M, Yeo BTT. Sensory-motor cortices shape functional connectivity dynamics in the human brain Nature Communications 2021, 12: 6373. PMID: 34737302, PMCID: PMC8568904, DOI: 10.1038/s41467-021-26704-y.
- Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSDBurt JB, Preller KH, Demirtas M, Ji JL, Krystal JH, Vollenweider FX, Anticevic A, Murray JD. Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD ELife 2021, 10: e69320. PMID: 34313217, PMCID: PMC8315798, DOI: 10.7554/elife.69320.
Clinical Trials
Conditions | Study Title |
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Mental Health & Behavioral Research | A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia |
Diseases of the Nervous System; Mental Health & Behavioral Research | Teen Brain and Behavior Study |
Diseases of the Nervous System; Mental Health & Behavioral Research | Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder |