Jason Greenberg, MD, MHS
Associate Professor of Pediatrics (Nephrology)
Research & Publications
Biography
News
Research Summary
Dr. Greenberg's research focuses on improving risk prediction in children with acute kidney injury and chronic kidney disease. He has particular interest in the development of novel biomarkers to predict kidney outcomes. In addition, he studies risk prediction of kidney disease in children with congenital heart disease. Ultimately, his goal is to improve clinical decision making and outcomes in children with kidney disease.
Coauthors
Research Interests
Pediatrics; Renal Insufficiency, Chronic; Biomarkers, Pharmacological; Translational Research, Biomedical; Acute Kidney Injury
Selected Publications
- Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS StudiesAmatruda J, Katz R, Rebholz C, Sarnak M, Gutierrez O, Schrauben S, Greenberg J, Coresh J, Cushman M, Waikar S, Parikh C, Schelling J, Jogalekar M, Bonventre J, Vasan R, Kimmel P, Ix J, Shlipak M, Consortium C. Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies. Kidney Medicine 2024, 6: 100834. PMID: 38826568, PMCID: PMC11141432, DOI: 10.1016/j.xkme.2024.100834.
- Is mild dehydration a risk for progression of childhood chronic kidney disease?Le Page A, Johnson E, Greenberg J. Is mild dehydration a risk for progression of childhood chronic kidney disease? Pediatric Nephrology 2024, 1-15. PMID: 38632124, DOI: 10.1007/s00467-024-06332-6.
- COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney OutcomesAklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.
- Long-Term Outcomes After Pediatric Non-Dialysis-Treated AKI: A Population-Based Cohort StudyRobinson C, Jeyakumar N, Askenazi D, Deep A, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Wald R, Zappitelli M, Chanchlani R. Long-Term Outcomes After Pediatric Non-Dialysis-Treated AKI: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2023, 34: 232-232. DOI: 10.1681/asn.20233411s1232a.
- Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in childrenPolitis M, Gutiérrez-Avila I, Just A, Pizano-Zárate M, Tamayo-Ortiz M, Greenberg J, Téllez-Rojo M, Sanders A, Rosa M. Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children. The Science Of The Total Environment 2023, 907: 168119. PMID: 37884142, PMCID: PMC10842020, DOI: 10.1016/j.scitotenv.2023.168119.
- Associations of Exposure to Urinary Metals with Kidney Injury Biomarkers among Pre-adolescent Children: A Cross-Sectional StudyPolitis M, Yao M, Gennings C, Ortiz M, Amarasiriwardena C, Pantic I, Tolentino M, Gutierrez G, Greenberg J, Rojo M, Sanders A, Rosa M. Associations of Exposure to Urinary Metals with Kidney Injury Biomarkers among Pre-adolescent Children: A Cross-Sectional Study. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.vo-032.
- Effect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and AdolescentsNugent J, Lu Y, Deng Y, Sharifi M, Greenberg J. Effect Measure Modification by Birth Weight on the Association Between Overweight or Obesity and Hypertension in Children and Adolescents. JAMA Pediatrics 2023, 177: 735-737. PMID: 37155182, PMCID: PMC10167596, DOI: 10.1001/jamapediatrics.2023.0799.
- Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKDJiang K, Greenberg J, Abraham A, Xu Y, Schelling J, Feldman H, Schrauben S, Waikar S, Shlipak M, Wettersten N, Coca S, Vasan R, Gutierrez O, Ix J, Warady B, Kimmel P, Bonventre J, Parikh C, Mitsnefes M, Denburg M, Furth S, Ramachandran V, Schelling J, Denburg M, Furth S, Warady B, Bonventre J, Waikar S, Sabbisetti V, Coresh J, Grams M, Rebholz C, Abraham A, Parikh C, Coca S, Rhee E, Kimmel P, Kusek J, Rovin B, Shlipak M, Sarnak M, Gutiérrez O, Ix J, Dubin R, Hostetter T, Deo R, Feldman H, Xie D, Shou H, Ballard S, Whitehead K, Collins H, Greenberg J, Ganz P. Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD. Kidney360 2023, 4: 1039-1047. PMID: 37303083, PMCID: PMC10476681, DOI: 10.34067/kid.0000000000000183.
- A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomesWilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.
- Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney DiseaseSandokji I, Xu Y, Denburg M, Furth S, Abraham A, Greenberg J. Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease. Nephron 2023, 148: 1-10. PMID: 37232009, PMCID: PMC10840447, DOI: 10.1159/000530918.
- Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized ChildrenNugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.
- Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of AtherosclerosisWettersten N, Katz R, Greenberg J, Gutierrez O, Lima J, Sarnak M, Schrauben S, Deo R, Bonventre J, Vasan R, Kimmel P, Shlipak M, Ix J. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis. The American Journal Of Cardiology 2023, 196: 11-18. PMID: 37086700, PMCID: PMC10204591, DOI: 10.1016/j.amjcard.2023.02.031.
- Association of clinical characteristics with urine uromodulin in children with chronic kidney diseaseFaulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.
- Does This Child With High Blood Pressure Have Secondary Hypertension?Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.
- WCN23-0514 Long-term kidney outcomes following pediatric acute kidney injury not receiving dialysis: A population-based propensity-matched cohort studyRobinson C, Jeyakumar N, Luo B, Askenazi D, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Thabane L, Wald R, Zappitelli M, Chanchlani R. WCN23-0514 Long-term kidney outcomes following pediatric acute kidney injury not receiving dialysis: A population-based propensity-matched cohort study. Kidney International Reports 2023, 8: s8-s9. DOI: 10.1016/j.ekir.2023.02.019.
- Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI studyde Fontnouvelle C, Zappitelli M, Thiessen-Philbrook H, Jia Y, Kimmel P, Kaufman J, Devarajan P, Parikh C, Greenberg J. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study. Pediatric Nephrology 2023, 38: 2851-2860. PMID: 36790467, DOI: 10.1007/s00467-023-05886-1.
- Biomarkers for acute kidney injury in children – where are we now?Sandokji I, Greenberg J. Biomarkers for acute kidney injury in children – where are we now? Current Opinion In Pediatrics 2023, 35: 245-250. PMID: 36601976, DOI: 10.1097/mop.0000000000001217.
- Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damageGhazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.
- Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in ChildrenPolitis M, Yao M, Gennings C, Tamayo-Ortiz M, Valvi D, Kim-Schulze S, Qi J, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Greenberg J, Téllez-Rojo M, Wright R, Sanders A, Rosa M. Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children. Toxics 2022, 10: 692. PMID: 36422900, PMCID: PMC9699100, DOI: 10.3390/toxics10110692.
- Antihypertensive Treatment and Clinical Outcomes Among Patients Who Develop Severe Hypertension During HospitalizationGhazi, Nugent J, Greenberg J, Bakhoum C, Wilson F. Antihypertensive Treatment and Clinical Outcomes Among Patients Who Develop Severe Hypertension During Hospitalization. Journal Of The American Society Of Nephrology 2022, 33: 528-528. DOI: 10.1681/asn.20223311s1528a.
- Kidney Tubule Injury and Dysfunction Biomarkers and Risk of Incident Hypertension in Community-Living Individuals: Results From the Multi-Ethnic Study of AtherosclerosisMalhotra R, Katz R, Kimmel P, Ramachandran V, Al-Rousan T, Greenberg J, Parikh C, Bonventre J, Schelling J, Sarnak M, Gutierrez O, Shlipak M, Ix J. Kidney Tubule Injury and Dysfunction Biomarkers and Risk of Incident Hypertension in Community-Living Individuals: Results From the Multi-Ethnic Study of Atherosclerosis. Journal Of The American Society Of Nephrology 2022, 33: 529-529. DOI: 10.1681/asn.20223311s1529a.
- Association of Urine Biomarkers of Tubule Health With Mortality in Patients With Diabetes and CKDVasquez-Rios G, Katz R, Cushman M, Parikh C, Kimmel P, Waikar S, Schrauben S, Greenberg J, Sarnak M, Shlipak M, Ix J, Gutierrez O. Association of Urine Biomarkers of Tubule Health With Mortality in Patients With Diabetes and CKD. Journal Of The American Society Of Nephrology 2022, 33: 116-116. DOI: 10.1681/asn.20223311s1116b.
- Associations of Prenatal Metals Exposure with Kidney Injury Biomarkers in ChildrenPolitis M, Yao M, Gennings C, Tamayo-Ortiz M, Valvi D, Kim-Schulze S, Qi J, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Greenberg J, Tellez-Rojo M, Wright R, Rosa M, Sanders A. Associations of Prenatal Metals Exposure with Kidney Injury Biomarkers in Children. ISEE Conference Abstracts 2022, 2022 DOI: 10.1289/isee.2022.o-op-279.
- Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in ChildrenGreenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S, Consortium O. Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. Journal Of The American Society Of Nephrology 2021, 32: 2664-2677. PMID: 34544821, PMCID: PMC8722795, DOI: 10.1681/asn.2021010094.
- Plasma Biomarkers and Incident CKD in Individuals Without DiabetesSarnak M, Katz R, Coca S, Greenberg J, Kimmel P, Sabbisetti V, Parikh C, Rebholz C, Waikar S, Schelling J, Zheng Z, Cushman M, Ramachandran V, Bonventre J, Shlipak M, Ix J, Gutierrez O. Plasma Biomarkers and Incident CKD in Individuals Without Diabetes. Journal Of The American Society Of Nephrology 2021, 32: 723-723. DOI: 10.1681/asn.20213210s1723b.
- Prevalence of Secondary Hypertension in Children with a New Diagnosis of Hypertension: A Meta-AnalysisNugent J, Young C, Funaro M, Ghazi, Wilson F, Greenberg J. Prevalence of Secondary Hypertension in Children with a New Diagnosis of Hypertension: A Meta-Analysis. Journal Of The American Society Of Nephrology 2021, 32: 837-838. DOI: 10.1681/asn.20213210s1837c.
- Urine Biomarkers and ESKD Risk in Persons with Diabetes and CKDAmatruda J, Katz R, Sarnak M, Gutierrez O, Greenberg J, Cushman M, Waikar S, Parikh C, Schelling J, Bonventre J, Ramachandran V, Kimmel P, Shlipak M, Ix J. Urine Biomarkers and ESKD Risk in Persons with Diabetes and CKD. Journal Of The American Society Of Nephrology 2021, 32: 261-261. DOI: 10.1681/asn.20213210s1261a.
- Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort StudyRobinson CH, Jeyakumar N, Luo B, Wald R, Garg AX, Nash DM, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh RS, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2021, 32: 2005-2019. PMID: 34039667, PMCID: PMC8455253, DOI: 10.1681/asn.2020111665.
- Electronic Health Record Alerts for AKI: A MultiCenter Randomized Clinical TrialWilson F, Martin M, Yamamoto Y, Feldman H, Greenberg J, Mansour S, Moledina D, Palevsky P, Parikh C, Simonov M. Electronic Health Record Alerts for AKI: A MultiCenter Randomized Clinical Trial. Journal Of The American Society Of Nephrology 2020, 31: b3-b3. DOI: 10.1681/asn.20203110s1b3c.
- Hypertension and CKD at 7 Years After Surgical Repair of Congenital Heart Disease in ChildrenGreenberg J, Zappitelli M, Philbrook H, Jia Y, Devarajan P, Parikh C. Hypertension and CKD at 7 Years After Surgical Repair of Congenital Heart Disease in Children. Journal Of The American Society Of Nephrology 2020, 31: 707-707. DOI: 10.1681/asn.20203110s1707b.