Gang-Qing Yao, MD
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Yale School of Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
About
Titles
Research Scientist in Medicine (Endocrinology)
Appointments
Endocrinology
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Chinese Academy of Medical Sciences (1987)
- MM
- Shandong Academy of Medical Sciences, Virology (1984)
- MD
- Gannan Medical University (1981)
- Fellow
- Chinese Academy of Medical Sciences
Research
Overview
Medical Subject Headings (MeSH)
Bone and Bones
Research at a Glance
Yale Co-Authors
Frequent collaborators of Gang-Qing Yao's published research.
Publications Timeline
A big-picture view of Gang-Qing Yao's research output by year.
Research Interests
Research topics Gang-Qing Yao is interested in exploring.
Karl Insogna, MD, FACP
Tamas Horvath, DVM, PhD
11Publications
158Citations
Bone and Bones
Publications
2015
AgRP Neurons Regulate Bone Mass
Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL. AgRP Neurons Regulate Bone Mass. Cell Reports 2015, 13: 8-14. PMID: 26411686, PMCID: PMC5868421, DOI: 10.1016/j.celrep.2015.08.070.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAgouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusBone DensityBone Diseases, MetabolicFemurGene Expression RegulationHomeostasisHypothalamusIon ChannelsLeptinMaleMiceMice, KnockoutMitochondrial ProteinsNeuronsNorepinephrinePhenotypePropranololReceptors, Adrenergic, betaReceptors, LeptinSignal TransductionSirtuin 1TibiaUncoupling Protein 2ConceptsAgRP neuronsCell-autonomous deletionSignificant regulatory roleAgRP neuronal functionBone massLeptin receptor deletionSkeletal bone metabolismTransgenic animalsRegulatory roleGene deletionBone homeostasisDeletionNeuronal functionPostnatal deletionSympathetic toneReceptor deletionArcuate nucleusLeptin actionBone metabolismSkeletal metabolismMultiple linesNeuronsMiceMetabolismCircuit integrity
2011
Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss
Yao GQ, Wu JJ, Troiano N, Zhu ML, Xiao XY, Insogna K. Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss. Journal Of Bone And Mineral Metabolism 2011, 30: 408-418. PMID: 22105655, PMCID: PMC4378684, DOI: 10.1007/s00774-011-0336-y.Peer-Reviewed Original ResearchCitationsMeSH KeywordsAnimalsBone and BonesBone DensityCell DifferentiationCells, CulturedCoculture TechniquesColony-Stimulating FactorsFemaleHumansHypertriglyceridemiaMaleMiceMice, KnockoutOsteoblastsOsteoclastsOsteoporosisOsteoporosis, PostmenopausalProtein IsoformsRNA, MessengerSex CharacteristicsSolubilityUp-Regulation
2010
Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice
Yao GQ, Wu JJ, Troiano N, Insogna K. Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice. Journal Of Bone And Mineral Metabolism 2010, 29: 141-148. PMID: 20602130, PMCID: PMC3457021, DOI: 10.1007/s00774-010-0202-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsParathyroid hormonePTH treatmentBone massTg miceAnabolic responseDKK1 expressionSingle daily subcutaneous doseDaily subcutaneous doseBone formationIntermittent PTH treatmentPotent anabolic agentOverexpression of DKK1Number of osteoblastsSubcutaneous doseWT miceReal-time PCRSkeletal sitesDickkopf-1Anabolic agentsBody weightTransgenic miceHistomorphometric parametersHistomorphometric analysisTargeted overexpressionPrimary murine osteoblasts
2009
Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice
Yao GQ, Wu JJ, Ovadia S, Troiano N, Sun BH, Insogna K. Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice. AJP Endocrinology And Metabolism 2009, 296: e714-e720. PMID: 19141689, PMCID: PMC2670621, DOI: 10.1152/ajpendo.90631.2008.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsColony-stimulating factor-1Nonredundant functionsWild-type animalsTransgenic miceMembrane-bound isoformMCSF1Normal osteoclastogenesisCollagen promoterTransgenic expressionMajor isoformsIsoformsFactor 1Same genotypeOp phenotypeTargeted overexpressionOverexpressionOp miceOsteoblastsAnimalsPromoterMicePhenotypeFemale animalsAlphaIMale littermates
2005
The Cell-Surface Isoform of Colony Stimulating Factor 1 (CSF1) Restores but Does Not Completely Normalize Fecundity in CSF1-Deficient Mice1
Ovadia S, Insogna K, Yao GQ. The Cell-Surface Isoform of Colony Stimulating Factor 1 (CSF1) Restores but Does Not Completely Normalize Fecundity in CSF1-Deficient Mice1. Biology Of Reproduction 2005, 74: 331-336. PMID: 16237150, DOI: 10.1095/biolreprod.105.045047.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsColony stimulating factor 1Viability of offspringReproductive defectsCell surfaceMembrane-bound isoformStimulating factor 1Cell surface isoformAlpha promoterMCSF1Transgenic animalsProteolytic sheddingCSF1 proteinMouse reproductionFactor 1ReproductionTransgenic male miceIsoformsTransgenic miceSperm numberOffspringTissue levelsMurine uterusGenetic absenceControl littermatesPromoter
2003
The Cell Surface Form of Colony-Stimulating Factor-1 Is Biologically Active in Bone in Vivo
Yao GQ, Wu JJ, Sun BH, Troiano N, Mitnick MA, Insogna K. The Cell Surface Form of Colony-Stimulating Factor-1 Is Biologically Active in Bone in Vivo. Endocrinology 2003, 144: 3677-3682. PMID: 12865350, DOI: 10.1210/en.2002-221071.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOp/op miceWild-type miceOp miceBone densityTooth eruptionTransgenic micePeripheral quantitative computed tomographyMCSF-1Factor 1Number of osteoclastsQuantitative computed tomographyOp/op animalsMolar tooth eruptionWild-type animalsOP animalsComputed tomographyColony-stimulating factor-1Colony stimulating factor 1Normal incisorsHistomorphometric analysis
2000
Nuclear Factor-κB p50 Is Required for Tumor Necrosis Factor-α-Induced Colony-Stimulating Factor-1 Gene Expression in Osteoblasts*
Yao G, Sun B, Insogna K, Weir E. Nuclear Factor-κB p50 Is Required for Tumor Necrosis Factor-α-Induced Colony-Stimulating Factor-1 Gene Expression in Osteoblasts*. Endocrinology 2000, 141: 2914-2922. DOI: 10.1210/en.141.8.2914.Peer-Reviewed Original ResearchConceptsCSF-1 expressionKnock-out miceCSF-1NF-kBColony-stimulating factor (CSF)-1Gene expressionColony-stimulating factor-1 gene expressionCSF-1 gene expressionElectrophoretic mobility shift assayTumor necrosis factor (TNF)-aBone-resorbing agentsHematopoietic growth factorsWild-type miceMobility shift assayCSF-1 promoterBone remodeling in vivoNF-kB bindingNF-kB sitesMessenger RNA expressionShift assaysRemodeling in vivoTranscriptional mechanismsNorthern analysisBcl-3C-Rel- 1. Weir EC, Yao GQ, Chen Y, Insogna K: Colony Stimulating Factors and Bone. In: Skeletal Growth Factors. Canalis, E. (ed.), Lippincott Williams& Wilkins, Media, PA 2000, p385-409Chapters
1989
[Studies on oncogene of nasopharyngeal carcinoma. I. Transforming activity of CNE-2 DNA in NIH3T3 cells].
Yao GQ. [Studies on oncogene of nasopharyngeal carcinoma. I. Transforming activity of CNE-2 DNA in NIH3T3 cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1989, 11: 112-5. PMID: 2528417.Peer-Reviewed Original Research
1988
- Yang, Zhihua, Yao GQ, Yi-Wan. Li. Study and Analysis on EBV/EMA and EBV DNA in Biopsies from Patients with Nasopharyngeal Carcinoma. Acta. Acad. Med. Sinicae 10,15 (1988)Peer-Reviewed Original Research
Academic Achievements and Community Involvement
activity PTH-dependent stabilization of RANKL mRNA is associated with a selective increase in binding of phosphorylated KSRP, an AU-rich element binding-protein, to RANKL transcripts
Poster PresentationASBMR Annual MeetingDetails10/13/2023 - PresentVancouver, BC, CanadaCollaboratorsactivity Parathyroid Hormone does not change the expression of adenylate-uridylate-rich element binding proteins as part of the mechanism by which it stabilizes Receptor Activator of NF Kappa B Ligand Transcripts
Poster PresentationASBMR Annual MeetingDetails09/07/2022 - PresentAustin, TX, United StatesCollaboratorsactivity The anabolic actions of PTH are mediated in part through a Colony Stimulating Factor 1-sphingosine-1-phosphate paracrine loop
Poster PresentationASBMR Annual MeetingDetails10/10/2018 - PresentAtlanta, GA, United StatesCollaboratorsactivity The anabolic actions of PTH are mediated in part through a Colony Stimulating Factor 1-sphingosine-1-phosphate paracrine loop
Poster PresentationASBMR Annual MeetingDetails10/11/2016 - PresentAtlanta, GA, United StatesCollaboratorsactivity Selective deletion of the Soluble Colony Stimulating Factor 1 isoform in vivo eliminates estrogen-deficiency bone loss in mice
Oral PresentationASBMR Annual MeetingDetails10/11/2012 - PresentMinneapolis, MN, United StatesCollaborators- Gang-Qing Yao, MD
- Sun, B-H
- Wu, J
- Karl Insogna, MD, FACP
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Yale School of Medicine
PO Box 208016
New Haven, CT 06520-8016
United States