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Erin Longbrake, MD/PhD

Associate Professor of Neurology; Director, Clinical Research, Neuroimmunology; Director, Fellowship Program, Multiple Sclerosis & Other Inflammatory Brain Disease

Contact Information

Erin Longbrake, MD/PhD

Research Summary

Dr. Longbrake directs the clinical and translational research program in neuroimmunology at Yale University. Her current work focuses on the relationships between the microbiome/metabolome, multiple sclerosis, and the immunomodulatory medications used to treat the disease. She is the PI for a national, investigator initiated clinical trial examining whether a short course of immunotherapy at the very earliest stages of MS can lead to sustained remission (CELLO study) and is working to decipher the earliest immune changes that occur leading up to a diagnosis of MS. Further information about Dr. Longbrake's research program can be found at her lab website.


Research Interests

Multiple Sclerosis; Neuromyelitis Optica; Autoimmune Diseases of the Nervous System

Public Health Interests

Genetics, Genomics, Epigenetics; Immunology; Nutrition; Microbiome

Selected Publications

Clinical Trials

ConditionsStudy Title
Diseases of the Nervous SystemCognitive Training Study in Parkinson’s Disease
Diseases of the Nervous SystemCELLO Study for Radiologically Isolated Syndrome (RIS)
Diseases of the Nervous SystemThe ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis (ExTINGUISH)
Diseases of the Nervous SystemMultiple Sclerosis: Symptoms and Hormones Study
COVID-19 Inpatient; COVID-19 OutpatientPatient response to COVID19 outbreak
Diseases of the Nervous SystemEvaluating the Immune Response to COVID-19 Vaccination in B-cell Depleted Patients
COVID-19 Inpatient; COVID-19 Outpatient; Diseases of the Nervous System; HIV/AIDS; Infectious DiseasesHIV Associated Reservoirs and Comorbidities (The HARC Plus Study)
Diseases of the Nervous SystemThe Brain Shuttle Study
Diseases of the Nervous SystemIdentifying and Characterizing Preclinical MS
Intestinal Immunity in Neurologic Disease