Edward Manning, MD, PhD
Assistant Professor of Medicine (Pulmonary)
Research & Publications
Biography
News
Research Summary
Dr. Manning’s research focuses on the remodeling of the cardiopulmonary system due to chronic hypoxia and aging with emphasis on the proximal pulmonary arteries. His approach to problems reflects the multi-disciplinary nature of his mentorship team at Yale and his collaborators, including biomedical engineering, genomics, lung physiology and vascular biology.
Coauthors
Selected Publications
- VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.
- Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung InjuryHarris Z, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin H, Manning E, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang M, Koff J. Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung Injury. 2023, a1256-a1256. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1256.
- The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During AgingYuan Y, Khoury J, Ramachandra A, Singh I, Tellides G, Humphrey J, Kaminski N, Manning E. The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging. 2023, a2680-a2680. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2680.
- Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.
- Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Lee P, Heerdt P, Singh I, Tellides G, Kaminski N, Humphrey J. Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary Artery. 2023, a6133-a6133. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6133.
- Patients With Acute Guillain-Barre Syndrome in Long-Term Acute CareWeil K, Baumann V, Brown B, Jano L, Nadeau R, Rosenblum D, Gerstenhaber B, Manning E. Patients With Acute Guillain-Barre Syndrome in Long-Term Acute Care. 2023, a3926-a3926. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3926.
- High-dimensional Analysis of Cell-cell Signaling in Pulmonary Biology and Disease Using NichesRaredon M, Yang J, Kothapalli N, Greaney A, Justet A, Adams T, Zhao A, Kim H, Manning E, Medzhitov R, Niklason L, Kaminski N, Kluger Y. High-dimensional Analysis of Cell-cell Signaling in Pulmonary Biology and Disease Using Niches. 2023, a4697-a4697. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4697.
- Prognostic variables and decannulation of tracheostomy in the long-term acute care environment: a case for clinician-driven decision-making.Weil K, Baumann V, Brown B, Nadeau R, Gerstenhaber B, Manning E. Prognostic variables and decannulation of tracheostomy in the long-term acute care environment: a case for clinician-driven decision-making. Journal Of Mechanical Ventilation 2023, 4: 1-8. PMID: 37426175, PMCID: PMC10328447, DOI: 10.53097/jmv.10069.
- Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung InjuryHarris ZM, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin HJ, Manning EP, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang MJ, Koff JL. Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury. Oxidative Medicine And Cellular Longevity 2022, 2022: 9518592. PMID: 36193076, PMCID: PMC9526641, DOI: 10.1155/2022/9518592.
- Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Singh I, Tellides G, Gill T, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary Artery. 2022, a5205-a5205. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5205.
- Prognostic Variables and Decannulation of Tracheostomy in the Long-Term Acute Care Hospital Environment: A Case for Clinician-Driven Decision-MakingWeil K, Baumann V, Brown B, Nadeau R, Gerstenhaber B, Manning E. Prognostic Variables and Decannulation of Tracheostomy in the Long-Term Acute Care Hospital Environment: A Case for Clinician-Driven Decision-Making. 2022, a4305-a4305. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4305.
- Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP. Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. Journal Of Biomechanical Engineering 2022, 144 PMID: 35171214, PMCID: PMC8990734, DOI: 10.1115/1.4053873.
- Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic DataManning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C, Singh I, Tellides G, Kaminski N, Humphrey JD. Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data. Frontiers In Physiology 2021, 12: 726253. PMID: 34594238, PMCID: PMC8478173, DOI: 10.3389/fphys.2021.726253.
- Integrated Single-Cell Atlas of Endothelial Cells of the Human LungSchupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe’er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/circulationaha.120.052318.
- Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from HypoxiaManning E, Ramachandra A, Schupp J, Cavinato C, Singh I, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from Hypoxia. 2021, a3625-a3625. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3625.
- Disinfection of Pseudomonas aeruginosa from N95 respirators with ozone: a pilot studyManning EP, Stephens MD, Dufresne S, Silver B, Gerbarg P, Gerbarg Z, Dela Cruz CS, Sharma L. Disinfection of Pseudomonas aeruginosa from N95 respirators with ozone: a pilot study. BMJ Open Respiratory Research 2021, 8: e000781. PMID: 33431507, PMCID: PMC7802653, DOI: 10.1136/bmjresp-2020-000781.
- The Correlation of Periostin and Type I Procollagen Alpha1 in Fibrocytes Associated with the Microenvironment Fibrotic Level in Bleomycin Challenged Mouse LungSun H, Peng X, Reeves B, Winkler J, Minasyan M, Manning E. The Correlation of Periostin and Type I Procollagen Alpha1 in Fibrocytes Associated with the Microenvironment Fibrotic Level in Bleomycin Challenged Mouse Lung. 2020, a2276-a2276. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2276.
- Web Exclusive. Annals On Call - Are VA Patients Different?Centor RM, Manning EP. Web Exclusive. Annals On Call - Are VA Patients Different? Annals Of Internal Medicine 2020, 172: oc1. PMID: 32066167, DOI: 10.7326/a19-0024.
- A Veteran-Centric Model of Care: Crossing the Cultural Divide.Manning EP. A Veteran-Centric Model of Care: Crossing the Cultural Divide. Annals Of Internal Medicine 2019, 171: 843-844. PMID: 31658471, PMCID: PMC7188555, DOI: 10.7326/m19-1264.
- Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosisRyu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. European Respiratory Journal 2019, 54: 1801762. PMID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.
- New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid HormoneManning EP, Losier A, Emeagwali N, Ryu C, Honiden S. New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1561-1563. PMID: 30822095, PMCID: PMC7051474, DOI: 10.1164/rccm.201809-1700rr.
- Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case reportHakim A, Bazan IS, Sanogo ML, Manning EP, Pollak JS, Chupp GL. Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report. BMC Pulmonary Medicine 2019, 19: 34. PMID: 30736787, PMCID: PMC6368789, DOI: 10.1186/s12890-019-0797-7.
- Early and prolonged opportunities to practice suturing increases medical student comfort with suturing during clerkships: Suturing during cadaver dissectionManning EP, Mishall PL, Weidmann MD, Flax H, Lan S, Erlich M, Burton WB, Olson TR, Downie SA. Early and prolonged opportunities to practice suturing increases medical student comfort with suturing during clerkships: Suturing during cadaver dissection. Anatomical Sciences Education 2018, 11: 605-612. PMID: 29603672, PMCID: PMC6165707, DOI: 10.1002/ase.1785.
- Is Repeating Direct-Fluorescent Antibody Testing for Influenza Beneficial?Manning EP, Moskowitz CS. Connecticut Medicine 2018; 82:487-488.
- Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen SeizuresManning EP. Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen Seizures. Aerospace Medicine And Human Performance 2016, 87: 477-486. PMID: 27099087, PMCID: PMC7092644, DOI: 10.3357/amhp.4463.2016.
- PhytobezoarInduced Small Bowel Obstruction in a Young Male with Virgin AbdomenManning EP, Vattipallly V, Niazi M, Shah A. PhytobezoarInduced Small Bowel Obstruction in a Young Male with Virgin Abdomen. Journal Of Gastrointestinal & Digestive System 2015, 05: 266. PMID: 29795770, PMCID: PMC5962263, DOI: 10.4172/2161-069x.1000266.
- Young Woman With Epigastric Pain and VomitingManning EP, Laskowski LK, Nelson LS, Touger M. Young Woman With Epigastric Pain and Vomiting. Annals Of Emergency Medicine 2014, 64: 330-333. PMID: 25149968, PMCID: PMC4203436, DOI: 10.1016/j.annemergmed.2013.12.022.
- Computational Prediction and Experimental Verification of Differential Calcium Affinity in Thin Filament Mutants Known to Cause Hypertrophic CardiomyopathyManning E, Lehman S, Schwartz S, Tardiff J. Computational Prediction and Experimental Verification of Differential Calcium Affinity in Thin Filament Mutants Known to Cause Hypertrophic Cardiomyopathy. Biophysical Journal 2014, 106: 349a. DOI: 10.1016/j.bpj.2013.11.1985.
- Molecular Effects of Familial Hypertrophic Cardiomyopathy-Related Mutations in the TNT1 Domain of cTnTManning EP, Tardiff JC, Schwartz SD. Molecular Effects of Familial Hypertrophic Cardiomyopathy-Related Mutations in the TNT1 Domain of cTnT. Journal Of Molecular Biology 2012, 421: 54-66. PMID: 22579624, PMCID: PMC3545441, DOI: 10.1016/j.jmb.2012.05.008.
- Correlation of Molecular and Functional Effects of Mutations in Cardiac Troponin T Linked to Familial Hypertrophic CardiomyopathyManning EP, Guinto PJ, Tardiff JC. Correlation of Molecular and Functional Effects of Mutations in Cardiac Troponin T Linked to Familial Hypertrophic Cardiomyopathy. Journal Of Biological Chemistry 2012, 287: 14515-14523. PMID: 22334656, PMCID: PMC3340284, DOI: 10.1074/jbc.m111.257436.
- A Model of Calcium Activation of the Cardiac Thin FilamentManning EP, Tardiff JC, Schwartz SD. A Model of Calcium Activation of the Cardiac Thin Filament. Biochemistry 2011, 50: 7405-7413. PMID: 21797264, PMCID: PMC3165030, DOI: 10.1021/bi200506k.
- Computational Modeling of Cardiac Troponin Dynamics: Elucidating a Regulatory Mechanism for Calcium Activation of the Thin FilamentManning E, Tardiff J, Schwartz S. Computational Modeling of Cardiac Troponin Dynamics: Elucidating a Regulatory Mechanism for Calcium Activation of the Thin Filament. Biophysical Journal 2011, 100: 225a. DOI: 10.1016/j.bpj.2010.12.1440.
- Structural and Functional Characterization of Cardiac Troponin T Mutations in the TNT1 Domain That Cause Familial Hypertrophic CardiomyopathyGuinto P, Manning E, Moore R, Schwartz S, Tardiff J. Structural and Functional Characterization of Cardiac Troponin T Mutations in the TNT1 Domain That Cause Familial Hypertrophic Cardiomyopathy. Biophysical Journal 2009, 96: 499a. DOI: 10.1016/j.bpj.2008.12.2575.
- COMPUTATIONAL CHARACTERIZATION OF MUTATIONS IN CARDIAC TROPONIN T KNOWN TO CAUSE FAMILIAL HYPERTROPHIC CARDIOMYOPATHYGuinto PJ, Manning EP, Schwartz SD, Tardiff JC. COMPUTATIONAL CHARACTERIZATION OF MUTATIONS IN CARDIAC TROPONIN T KNOWN TO CAUSE FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. Journal Of Computational Biophysics And Chemistry 2007, 6: 413-419. PMID: 26500385, PMCID: PMC4617307, DOI: 10.1142/s0219633607003271.
- Dehydration in extreme temperatures while conducting stability and support operations in a combat zone.Manning EP, Wilson B. Dehydration in extreme temperatures while conducting stability and support operations in a combat zone. Military Medicine 2007, 172: 972-6. PMID: 17937362, DOI: 10.7205/milmed.172.9.972.
- Room Temperature Synthesis of Ferroelectric Barium Titanate Nanoparticles Using Peptide Nanorings as Templates.Nuraje N, Su K, Haboosheh A, Samson J, Manning EP, Yang NL, Matsui H. Room Temperature Synthesis of Ferroelectric Barium Titanate Nanoparticles Using Peptide Nanorings as Templates. Advanced Materials (Deerfield Beach, Fla.) 2006, 18: 807-811. PMID: 31031545, PMCID: PMC6482853, DOI: 10.1002/adma.200501340.