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David Spiegel, MD, PhD

Professor of Chemistry

Contact Information

David Spiegel, MD, PhD

Research Summary

The Spiegel Laboratory works
in the area of “Synthetic Immunology,” which integrates synthetic chemistry,
immunology, and cell biology toward the development of systems capable of
controlling and/or creating human immunity. In particular, the lab has developed
a class of antibody-recruiting small molecules (ARMs) that are capable
of enhancing recognition of diverse pathogens by the human immune system. We
have successfully employed this approach in targeting both HIV and prostate
cancer, and are currently expanding its scope toward other diseases as
well. Other areas of interest
include re-engineering bacteria to perform complex immunological tasks, and
investigations into advanced glycation end-products (AGEs), a poorly understood
class of immunomodulatory post-translational modifications of proteins.


Research Interests

Pharmacology; Virology

Selected Publications