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Barbara Burtness, MD

Professor of Medicine (Medical Oncology); Chief Translational Research Officer, Yale Cancer Center; Chief, Head and Neck Cancers/Sarcoma; Co-Leader, Developmental Therapeutics, Yale Cancer Center; Associate Cancer Center Director for Translational Research, Yale Cancer Center

Research Summary

Studies of targeted treatments for EGFR expressed head and neck cancers, including biomarkers of resistance and novel strategies such as dual EGFR blockade, to overcome resistance. She leads the ECOG-ACRIN Head and Neck Therapeutics Committee, which conducts large multicenter trials in head and neck cancer, including studies of treatment deintensification in HPV-associated cancer, and molecularly guided post-operative therapy. She chairs multicenter trials of targeted therapy and immunotherapy in head and neck cancer.

Specialized Terms: EGFR expressed head and neck cancers.

Extensive Research Description

Studies of targeted treatments for EGFR expressed head and neck cancers, including biomarkers of resistance and novel strategies such as dual EGFR blockade, to overcome resistance. She has demonstrated that loss of PTEN indicates resistance to EGFR inhibition in head and neck cancer, and studied novel dual EGFR/HDAC inhibitors and combined antibody and tyrosine kinase inhibition as strategies to improve responsiveness to EGFR inhibition. She leads the ECOG-ACRIN Head and Neck Therapeutics Committee, which conducts large multicenter trials in head and neck cancer, and chairs multicenter trials of targeted therapy and immunotherapy in head and neck cancer. Her laboratory studies novel combinatorial therapies to target p53 mutated head and neck cancer.

Coauthors

Research Interests

Drug Therapy; Head and Neck Neoplasms; Medical Oncology; Chemicals and Drugs; Analytical, Diagnostic and Therapeutic Techniques and Equipment

Selected Publications

  • 133 Spatially defined gene signatures uncover the association of extracellular matrix genes with immunotherapy resistance in head and neck squamous cell carcinomaGavrielatou N, Warrell J, Aung T, Vathiotis L, Economopoulou P, Burtness B, Psyrri A, Rimm D. 133 Spatially defined gene signatures uncover the association of extracellular matrix genes with immunotherapy resistance in head and neck squamous cell carcinoma 2022, a146-a146. DOI: 10.1136/jitc-2022-sitc2022.0133.
  • Screening for Extranodal Extension with Deep Learning: Evaluation in ECOG-ACRIN E3311, a Randomized De-Escalation Trial for HPV-Associated Oropharyngeal CarcinomaKann B, Likitlersuang J, Ye Z, Aneja S, Bakst R, Kelly H, Juliano A, Payabvash S, Guenette J, Uppaluri R, Margalit D, Schoenfeld J, Tishler R, Haddad R, Aerts H, Garcia J, Flamand Y, Subramaniam R, Burtness B, Ferris R. Screening for Extranodal Extension with Deep Learning: Evaluation in ECOG-ACRIN E3311, a Randomized De-Escalation Trial for HPV-Associated Oropharyngeal Carcinoma International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s26-s27. DOI: 10.1016/j.ijrobp.2022.07.379.
  • Reduced Aspiration Rates for 50 Gy Postoperative Radiation in HPV-Associated Oropharynx Cancer in E3311: A Trial of the ECOG-ACRIN Cancer Research GroupHutcheson K, Peterson C, Barbon C, Quon H, Mehra R, Ringash J, Lewin J, Flamand Y, Duvvuri U, Ozer E, Thomas G, Kupferman M, Koch W, Bell R, Saba N, Panwar A, Annino D, Wagner L, Ferris R, Burtness B. Reduced Aspiration Rates for 50 Gy Postoperative Radiation in HPV-Associated Oropharynx Cancer in E3311: A Trial of the ECOG-ACRIN Cancer Research Group International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s27-s28. DOI: 10.1016/j.ijrobp.2022.07.380.
  • 658MO Pembrolizumab (pembro) vs standard-of-care (SOC) in previously treated recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): 6-year follow-up of KEYNOTE-040Soulieres D, Harrington K, Le Tourneau C, Silva J, Licitra L, Ahn M, Soria A, Machiels J, Mach N, Mehra R, Burtness B, Lin J, Lerman N, Gumuscu B, Cohen E. 658MO Pembrolizumab (pembro) vs standard-of-care (SOC) in previously treated recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): 6-year follow-up of KEYNOTE-040 Annals Of Oncology 2022, 33: s843. DOI: 10.1016/j.annonc.2022.07.782.
  • 659MO Pembrolizumab with or without chemotherapy for first-line treatment of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): 5-year results from KEYNOTE-048Tahara M, Greil R, Rischin D, Harrington K, Burtness B, De Castro G, Psyrri A, Brana I, Neupane P, Bratland Å, Fuereder T, Hughes B, Nin R, Ngamphaiboon N, Rordorf T, Ishak W, Lin J, Gumuscu B, Lerman N, Soulieres D. 659MO Pembrolizumab with or without chemotherapy for first-line treatment of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): 5-year results from KEYNOTE-048 Annals Of Oncology 2022, 33: s844. DOI: 10.1016/j.annonc.2022.07.783.
  • LBA5 Primary results of the phase III KEYNOTE-412 study: Pembrolizumab (pembro) with chemoradiation therapy (CRT) vs placebo plus CRT for locally advanced (LA) head and neck squamous cell carcinoma (HNSCC)Machiels J, Tao Y, Burtness B, Tahara M, Rischin D, Alves G, Lima I, Hughes B, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnal M, Licitra L, Swaby R, Zhang Y, Gumuscu B, Bidadi B, Siu L. LBA5 Primary results of the phase III KEYNOTE-412 study: Pembrolizumab (pembro) with chemoradiation therapy (CRT) vs placebo plus CRT for locally advanced (LA) head and neck squamous cell carcinoma (HNSCC) Annals Of Oncology 2022, 33: s1399. DOI: 10.1016/j.annonc.2022.08.029.
  • Abstract CT111: Phase 1/2 study of pepinemab, an inhibitor of semaphorin 4D, in combination with pembrolizumab as first-line treatment of recurrent or metastatic head and neck cancer (KEYNOTE B84)Fisher T, Evans E, Mallow C, Foster A, Boise M, Smith E, Leonard J, Chaney M, Beck J, Hager S, Saba N, Steuer C, Adkins D, Burtness B, Zauderer M. Abstract CT111: Phase 1/2 study of pepinemab, an inhibitor of semaphorin 4D, in combination with pembrolizumab as first-line treatment of recurrent or metastatic head and neck cancer (KEYNOTE B84) Cancer Research 2022, 82: ct111-ct111. DOI: 10.1158/1538-7445.am2022-ct111.
  • Phase 1/2 study of pepinemab, an inhibitor of semaphorin 4D, in combination with pembrolizumab as first-line treatment of recurrent or metastatic head and neck cancer (KEYNOTE-B84).Fisher T, Evans E, Mallow C, Foster A, Boise M, Smith E, Leonard J, Chaney M, Beck J, Hager S, Mekhail T, Seetharamu N, Baumgart M, Saba N, Steuer C, Adkins D, Burtness B, Zauderer M. Phase 1/2 study of pepinemab, an inhibitor of semaphorin 4D, in combination with pembrolizumab as first-line treatment of recurrent or metastatic head and neck cancer (KEYNOTE-B84). Journal Of Clinical Oncology 2022, 40: e18033-e18033. DOI: 10.1200/jco.2022.40.16_suppl.e18033.
  • A phase II/III trial of chemotherapy plus cetuximab versus chemotherapy plus bevacizumab versus atezolizumab plus bevacizumab following progression on immune checkpoint inhibition in recurrent/metastatic head and neck cancers: ECOG-ACRIN EA3202.Bhatia A, Flamand Y, Johnson J, Ishizuka J, Duan F, Tang M, Karivedu V, Subramaniam R, Burtness B. A phase II/III trial of chemotherapy plus cetuximab versus chemotherapy plus bevacizumab versus atezolizumab plus bevacizumab following progression on immune checkpoint inhibition in recurrent/metastatic head and neck cancers: ECOG-ACRIN EA3202. Journal Of Clinical Oncology 2022, 40: tps6098-tps6098. DOI: 10.1200/jco.2022.40.16_suppl.tps6098.
  • Outcomes by tobacco history in E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group.Mehra R, Flamand Y, Quon H, Garcia J, Weinstein G, Duvvuri U, O'Malley B, Ozer E, Thomas G, Koch W, Gross N, Bell R, Saba N, Lango M, Bayon R, Burtness B, Ferris R. Outcomes by tobacco history in E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group. Journal Of Clinical Oncology 2022, 40: 6077-6077. DOI: 10.1200/jco.2022.40.16_suppl.6077.
  • PET/CT radiomics potentially improves progression-free survival (PFS) and overall survival (OS) prognostication beyond UICC TNM staging in oropharyngeal squamous cell carcinoma (OPSCC) patientsHaider S, Sharaf K, Zeevi T, Mahajan A, Forghani R, Judson B, Kann B, Burtness B, Reichel C, Baumeister P, Payabvash S. PET/CT radiomics potentially improves progression-free survival (PFS) and overall survival (OS) prognostication beyond UICC TNM staging in oropharyngeal squamous cell carcinoma (OPSCC) patients Laryngo-Rhino-Otologie 2022, 101: s184-s184. DOI: 10.1055/s-0042-1746471.
  • PET/CT-Radiomics zuzüglich zum UICC-Staging könnten die Prognostik des Progressionsfreien Überlebens (PFS) und Gesamtüberlebens (OS) beim Oropharyngealen Plattenepithelkarzinom (OPSCC) verbessernHaider S, Sharaf K, Zeevi T, Mahajan A, Forghani R, Judson B, Kann B, Burtness B, Reichel C, Baumeister P, Payabvash S. PET/CT-Radiomics zuzüglich zum UICC-Staging könnten die Prognostik des Progressionsfreien Überlebens (PFS) und Gesamtüberlebens (OS) beim Oropharyngealen Plattenepithelkarzinom (OPSCC) verbessern Laryngo-Rhino-Otologie 2022, 101: s13-s13. DOI: 10.1055/s-0042-1747116.
  • Phase 1/2 Study of Pepinemab in Combination with Pembrolizumab as First-Line Treatment of Advanced, Recurrent or Metastatic Head and Neck Cancer (KEYNOTE B84)Fisher T, Evans E, Mallow C, Foster A, Boise M, Smith E, Leonard J, Chaney M, Beck J, Hager S, Saba N, Steuer C, Adkins D, Burtness B, Zauderer M. Phase 1/2 Study of Pepinemab in Combination with Pembrolizumab as First-Line Treatment of Advanced, Recurrent or Metastatic Head and Neck Cancer (KEYNOTE B84) International Journal Of Radiation Oncology • Biology • Physics 2022, 112: e36. DOI: 10.1016/j.ijrobp.2021.12.084.
  • Trilynx: A Phase 3 Trial of Xevinapant and Concurrent Chemoradiotherapy (CRT) for Locally Advanced Head and Neck CancerSchoenfeld J, Cohen E, Nutting C, Licitra L, Burtness B, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Bourhis J. Trilynx: A Phase 3 Trial of Xevinapant and Concurrent Chemoradiotherapy (CRT) for Locally Advanced Head and Neck Cancer International Journal Of Radiation Oncology • Biology • Physics 2022, 112: e20-e21. DOI: 10.1016/j.ijrobp.2021.12.046.
  • Phase 2 LEAP-009: Lenvatinib (Lenva) With or Without Pembrolizumab (Pembro) vs. Chemotherapy (Chemo) for Recurrent or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC) That has Progressed on Platinum and ImmunotherapyHarrington K, Cohen E, Siu L, Rischin D, Licitra L, Vermorken J, Le Q, Tahara M, Machiels J, Hawk N, Ge J, Bidadi B, Swaby R, Burtness B. Phase 2 LEAP-009: Lenvatinib (Lenva) With or Without Pembrolizumab (Pembro) vs. Chemotherapy (Chemo) for Recurrent or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC) That has Progressed on Platinum and Immunotherapy International Journal Of Radiation Oncology • Biology • Physics 2022, 112: e43-e44. DOI: 10.1016/j.ijrobp.2021.12.101.
  • Predictive Molecular Biomarkers for HPV-Associated Head and Neck Squamous Cell CarcinomaYarbrough W, Schrank T, Blumberg J, Patel S, Hackman T, Lumley C, Burtness B, Issaeva N. Predictive Molecular Biomarkers for HPV-Associated Head and Neck Squamous Cell Carcinoma International Journal Of Radiation Oncology • Biology • Physics 2022, 112: e17-e18. DOI: 10.1016/j.ijrobp.2021.12.178.
  • 438 A phase 1 trial of CUE-101, a novel HPV16 E7-pHLA-IL2-Fc fusion protein, alone and in combination with pembrolizumab in patients with recurrent/metastatic HPV16+ head and neck cancerChung C, Colevas A, Gibson M, Adkins D, Sukari A, Wirth L, Burtness B, Bauman J, Rodriguez C, Worden F, Saba N, Glisson B, Dunn L, Seiwert T, Agensky L, Levisetti M, Lynam R, Margossian S, Moniz R, Quayle S, Pienta K, Pai S. 438 A phase 1 trial of CUE-101, a novel HPV16 E7-pHLA-IL2-Fc fusion protein, alone and in combination with pembrolizumab in patients with recurrent/metastatic HPV16+ head and neck cancer Journal For ImmunoTherapy Of Cancer 2021, 9: a468-a468. DOI: 10.1136/jitc-2021-sitc2021.438.
  • Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-Treatment DNA Methylation in Peripheral BloodQian D, Ulrich B, Peng G, Zhao H, Conneely K, Miller A, Bruner D, Eldridge R, Wommack E, Higgins K, Shin D, Saba N, Smith A, Burtness B, Park H, Stokes W, Beitler J, Xiao C. Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-Treatment DNA Methylation in Peripheral Blood International Journal Of Radiation Oncology • Biology • Physics 2021, 111: s143-s144. DOI: 10.1016/j.ijrobp.2021.07.323.
  • P-88 First-Line Pembrolizumab With or Without Lenvatinib in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC): Phase 3 LEAP-010 StudyHarrington K, Siu L, Burtness B, Cohen E, Licitra L, Rischin D, Zhu Y, Okpara C, Pinheiro C, Swaby R, Machiels J, Tahara M. P-88 First-Line Pembrolizumab With or Without Lenvatinib in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC): Phase 3 LEAP-010 Study Oral Oncology 2021, 118: 7-8. DOI: 10.1016/s1368-8375(21)00375-4.
  • P-94 Pembrolizumab plus lenvatinib vs chemotherapy and lenvatinib monotherapy for recurrent/metastatic head and neck squamous cell carcinoma that progressed on platinum therapy and immunotherapy: LEAP-009Harrington K, Cohen E, Siu L, Rischin D, Licitra L, Vermorken J, Le Q, Tahara M, Machiels J, Hawk N, Ge J, Bidadi B, Swaby R, Burtness B. P-94 Pembrolizumab plus lenvatinib vs chemotherapy and lenvatinib monotherapy for recurrent/metastatic head and neck squamous cell carcinoma that progressed on platinum therapy and immunotherapy: LEAP-009 Oral Oncology 2021, 118: 10-11. DOI: 10.1016/s1368-8375(21)00381-x.
  • Updated report of a phase II randomized trial of transoral surgical resection followed by low-dose or standard postoperative therapy in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN cancer research group (E3311).Ferris R, Flamand Y, Weinstein G, Li S, Quon H, Mehra R, Garcia J, Ringash J, Lewin J, Duvvuri U, O'Malley B, Ozer E, Thomas G, Koch W, Kupferman M, Bell R, Saba N, Lango M, Wagner L, Burtness B. Updated report of a phase II randomized trial of transoral surgical resection followed by low-dose or standard postoperative therapy in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN cancer research group (E3311). Journal Of Clinical Oncology 2021, 39: 6010-6010. DOI: 10.1200/jco.2021.39.15_suppl.6010.
  • TRYHARD, a randomized phase II trial (RTOG Foundation 3501) of concurrent accelerated radiation plus cisplatin (cis) with or without lapatinib (Lap) for stage III- IV Non-HPV head and neck carcinoma (HNC).Wong S, Torres-Saavedra P, Saba N, Shenouda G, Bumpous J, Wallace R, Chung C, El-Naggar A, Gwede C, Burtness B, Tennant P, Dunlap N, Mell L, Spencer S, Stokes W, Yao M, Mitchell D, Harris J, Curran W, Le Q. TRYHARD, a randomized phase II trial (RTOG Foundation 3501) of concurrent accelerated radiation plus cisplatin (cis) with or without lapatinib (Lap) for stage III- IV Non-HPV head and neck carcinoma (HNC). Journal Of Clinical Oncology 2021, 39: 6014-6014. DOI: 10.1200/jco.2021.39.15_suppl.6014.
  • Randomized phase II trial of ficlatuzumab with or without cetuximab in pan-refractory, advanced head and neck squamous cell carcinoma (HNSCC).Bauman J, Saba N, Roe D, Bauman J, Kaczmar J, Bhatia A, Muzaffar J, Julian R, Wang S, Bearelly S, Baker A, Steuer C, Giri A, Burtness B, Centuori S, Caulin C, Saboda K, Obara S, Chung C. Randomized phase II trial of ficlatuzumab with or without cetuximab in pan-refractory, advanced head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2021, 39: 6015-6015. DOI: 10.1200/jco.2021.39.15_suppl.6015.
  • Efficacy and toxicity of weekly paclitaxel, carboplatin, and cetuximab as induction chemotherapy or in cases of metastases or relapse for head and neck cancer in elderly or frail patients.Forman R, Bhatia A, Burtness B. Efficacy and toxicity of weekly paclitaxel, carboplatin, and cetuximab as induction chemotherapy or in cases of metastases or relapse for head and neck cancer in elderly or frail patients. Journal Of Clinical Oncology 2021, 39: 6042-6042. DOI: 10.1200/jco.2021.39.15_suppl.6042.
  • TrilynX: A phase 3 trial of xevinapant and concurrent chemoradiation for locally advanced head and neck cancer.Bourhis J, Burtness B, Licitra L, Nutting C, Schoenfeld J, Sarkouh R, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen E. TrilynX: A phase 3 trial of xevinapant and concurrent chemoradiation for locally advanced head and neck cancer. Journal Of Clinical Oncology 2021, 39: tps6091-tps6091. DOI: 10.1200/jco.2021.39.15_suppl.tps6091.
  • Entwicklung bildbasierter Radiomics-Biomarker für den Humanen Papillomavirus (HPV)-Status beim oropharyngealen Plattenepithelkarzinom (OPSCC) mittels Machine-Learning-AlgorithmenHaider S, Mahajan A, Zeevi T, Forghani R, Kann B, Judson B, Burtness B, Sharaf K, Reichel C, Baumeister P, Payabvash S. Entwicklung bildbasierter Radiomics-Biomarker für den Humanen Papillomavirus (HPV)-Status beim oropharyngealen Plattenepithelkarzinom (OPSCC) mittels Machine-Learning-Algorithmen Laryngo-Rhino-Otologie 2021, 100: s65. DOI: 10.1055/s-0041-1727786.
  • Devising novel imaging biomarkers for Human Papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC): applying radiomics and machine learning algorithmsHaider S, Mahajan A, Zeevi T, Forghani R, Kann B, Judson B, Burtness B, Sharaf K, Reichel C, Baumeister P, Payabvash S. Devising novel imaging biomarkers for Human Papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC): applying radiomics and machine learning algorithms Laryngo-Rhino-Otologie 2021, 100: s99. DOI: 10.1055/s-0041-1727889.
  • 71P A phase II study of ADU-S100 in combination with pembrolizumab in adult patients with PD-L1+ recurrent or metastatic HNSCC: Preliminary safety, efficacy and PK/PD resultsZandberg D, Ferris R, Laux D, Mehra R, Nabell L, Kaczmar J, Gibson M, Kim Y, Neupane P, Bauman J, Julian R, Adkins D, Cohen E, Burtness B, Bermingham C, Dupage A, Desbien A, Loi A, Nuyten D, Saba N. 71P A phase II study of ADU-S100 in combination with pembrolizumab in adult patients with PD-L1+ recurrent or metastatic HNSCC: Preliminary safety, efficacy and PK/PD results Annals Of Oncology 2020, 31: s1446-s1447. DOI: 10.1016/j.annonc.2020.10.559.
  • 351 Pembrolizumab plus lenvatinib vs chemotherapy and lenvatinib monotherapy for recurrent/metastatic head and neck squamous cell carcinoma that progressed on platinum therapy and immunotherapy: LEAP-009Harrington K, Cohen E, Siu L, Rischin D, Licitra L, Vermorken J, Le Q, Tahara M, Machiels J, Hawk N, Ge J, Bidadi B, Swaby R, Burtness B. 351 Pembrolizumab plus lenvatinib vs chemotherapy and lenvatinib monotherapy for recurrent/metastatic head and neck squamous cell carcinoma that progressed on platinum therapy and immunotherapy: LEAP-009 Journal For ImmunoTherapy Of Cancer 2020, 8: a376-a376. DOI: 10.1136/jitc-2020-sitc2020.0351.
  • 354 A phase 1 trial of CUE-101 a novel HPV16 E7-pHLA-IL2-Fc fusion protein in patients with recurrent/metastatic HPV16+ head and neck cancerPai S, Adkins D, Wirth L, Chung C, Gibson M, Sukari A, Worden F, Colevas D, Saba N, Burtness B, Rodriguez C, Bauman J, Glisson B, Dunn L, Suri A, Haydock M, Quayle S, Cemerski S, Leader M, Brown J, Pienta K, Simcox M. 354 A phase 1 trial of CUE-101 a novel HPV16 E7-pHLA-IL2-Fc fusion protein in patients with recurrent/metastatic HPV16+ head and neck cancer 2020, a216.1-a216. DOI: 10.1136/jitc-2020-sitc2020.0354.
  • LEAP-010: Phase III study of first-line pembrolizumab with or without lenvatinib in patients (pts) with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)Siu L, Burtness B, Cohen E, Harrington K, Licitra L, Rischin D, Zhu Y, Okpara C, Pinheiro C, Swaby R, Machiels J, Tahara M. LEAP-010: Phase III study of first-line pembrolizumab with or without lenvatinib in patients (pts) with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) Annals Of Oncology 2020, 31: s683-s684. DOI: 10.1016/j.annonc.2020.08.1088.
  • Long-term outcomes from KEYNOTE-048: Pembrolizumab (pembro) alone or with chemotherapy (pembro+C) vs EXTREME (E) as first-line (1L) therapy for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)Greil R, Rischin D, Harrington K, Soulières D, Tahara M, de Castro G, Psyrri A, Baste N, Neupane P, Bratland Å, Fuereder T, Hughes B, Mesia R, Ngamphaiboon N, Rordorf T, Ishak W, Lin J, Swaby R, Gumuscu B, Burtness B. Long-term outcomes from KEYNOTE-048: Pembrolizumab (pembro) alone or with chemotherapy (pembro+C) vs EXTREME (E) as first-line (1L) therapy for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) Annals Of Oncology 2020, 31: s660-s661. DOI: 10.1016/j.annonc.2020.08.1030.
  • Abstract LB-258: Efficacy of first-line (1L) pembrolizumab by PD-L1 combined positive score <1, 1-19, and ≥20 in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): KEYNOTE-048 subgroup analysisBurtness B, Rischin D, Greil R, Soulières D, Tahara M, de Castro G, Psyrri A, Basté N, Neupane P, Bratland Å, Fuereder T, Hughes B, Mesia R, Ngamphaiboon N, Rordorf T, Ishak W, Ge J, Swaby R, Gumuscu B, Harrington K. Abstract LB-258: Efficacy of first-line (1L) pembrolizumab by PD-L1 combined positive score <1, 1-19, and ≥20 in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): KEYNOTE-048 subgroup analysis Cancer Research 2020, 80: lb-258-lb-258. DOI: 10.1158/1538-7445.am2020-lb-258.
  • Abstract IA20: Radiotherapy plus cetuximab or cisplatin in human papilloma-virus positive oropharyngeal cancer (NRG 1016): A randomized multicenter noninferiority trial*Ridge J, Ringash J, Yao M, Blakaj D, Razaq M, Colevas A, Beitler J, Jones C, Dunlap N, Seaward S, Spencer S, Galloway T, Dignam J, Le Q, Gillison M, Sturgis E, Phan J, Trotti A, Harris J, Eisbruch A, Harari P, Adelstein D, Koyfman S, Burtness B. Abstract IA20: Radiotherapy plus cetuximab or cisplatin in human papilloma-virus positive oropharyngeal cancer (NRG 1016): A randomized multicenter noninferiority trial* Clinical Cancer Research 2020, 26: ia20-ia20. DOI: 10.1158/1557-3265.aacrahns19-ia20.
  • Transoral robotic surgical resection followed by randomization to low- or standard-dose IMRT in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN Cancer Research Group (E3311).Ferris R, Flamand Y, Weinstein G, Li S, Quon H, Mehra R, Garcia J, Chung C, Gillison M, Duvvuri U, O'malley B, Ozer E, Thomas G, Koch W, Kupferman M, Bell R, Saba N, Lango M, Mendez E, Burtness B. Transoral robotic surgical resection followed by randomization to low- or standard-dose IMRT in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN Cancer Research Group (E3311). Journal Of Clinical Oncology 2020, 38: 6500-6500. DOI: 10.1200/jco.2020.38.15_suppl.6500.
  • KEYNOTE-048: Progression after the next line of therapy following pembrolizumab (P) or P plus chemotherapy (P+C) vs EXTREME (E) as first-line (1L) therapy for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).Harrington K, Rischin D, Greil R, Soulieres D, Tahara M, Castro G, Psyrri A, Baste N, Neupane P, Bratland Å, Fuereder T, Hughes B, Mesia R, Ngamphaiboon N, Rordorf T, Wan Ishak W, Zhang Y, Gumuscu B, Swaby R, Burtness B. KEYNOTE-048: Progression after the next line of therapy following pembrolizumab (P) or P plus chemotherapy (P+C) vs EXTREME (E) as first-line (1L) therapy for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2020, 38: 6505-6505. DOI: 10.1200/jco.2020.38.15_suppl.6505.
  • Pembrolizumab (P) or P + chemotherapy (C) versus EXTREME (E) as first-line (1L) therapy for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): analysis of KEYNOTE-048 by disease state.Rischin D, Harrington K, Greil R, Soulieres D, Tahara M, Castro G, Psyrri A, Baste N, Neupane P, Bratland Å, Fuereder T, Hughes B, Mesia R, Ngamphaiboon N, Rordorf T, Wan Ishak W, Lin J, Gumuscu B, Swaby R, Burtness B. Pembrolizumab (P) or P + chemotherapy (C) versus EXTREME (E) as first-line (1L) therapy for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): analysis of KEYNOTE-048 by disease state. Journal Of Clinical Oncology 2020, 38: 6530-6530. DOI: 10.1200/jco.2020.38.15_suppl.6530.
  • Correlation of tumor mutational burden (TMB) with CDKN2A and TP53 mutation in HPV-negative head and neck squamous cell carcinoma (HNSCC).Burtness B, Deneka A, Baca Y, Serebriiskii I, Parker M, Nicolas E, Lee J, Wise-Draper T, Sukari A, Somer B, Golemis E. Correlation of tumor mutational burden (TMB) with CDKN2A and TP53 mutation in HPV-negative head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2020, 38: 6552-6552. DOI: 10.1200/jco.2020.38.15_suppl.6552.
  • Phase III LEAP-010 study: first-line pembrolizumab with or without lenvatinib in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).Siu L, Burtness B, Cohen E, Harrington K, Licitra L, Rischin D, Zhu Y, Lee C, Pinheiro C, Swaby R, Machiels J, Tahara M. Phase III LEAP-010 study: first-line pembrolizumab with or without lenvatinib in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2020, 38: tps6589-tps6589. DOI: 10.1200/jco.2020.38.15_suppl.tps6589.
  • Randomized, phase II study of ficlatuzumab with or without cetuximab in patients with pan-refractory, recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).Bauman J, Roe D, Saba N, Bauman J, Kaczmar J, Burtness B, Muzaffar J, Julian R, Wang S, Bearelly S, Baker A, Steuer C, Bhatia A, Giri A, Caulin C, Stabile L, Centuori S, Chung C. Randomized, phase II study of ficlatuzumab with or without cetuximab in patients with pan-refractory, recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2020, 38: tps6594-tps6594. DOI: 10.1200/jco.2020.38.15_suppl.tps6594.
  • Devising novel imaging biomarkers for Human Papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC): applying radiomics and machine learning algorithmsHaider S, Mahajan A, Zeevi T, Forghani R, Kann B, Judson B, Burtness B, Sharaf K, Reichel C, Baumeister P, Payabvash S. Devising novel imaging biomarkers for Human Papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC): applying radiomics and machine learning algorithms Laryngo-Rhino-Otologie 2020, 99: s163. DOI: 10.1055/s-0040-1711024.
  • Entwicklung bildbasierter Radiomics-Biomarker für den Humanen Papillomavirus (HPV)-Status beim oropharyngealen Plattenepithelkarzinom (OPSCC) mittels Machine-Learning-AlgorithmenHaider S, Mahajan A, Zeevi T, Forghani R, Kann B, Judson B, Burtness B, Sharaf K, Reichel C, Baumeister P, Payabvash S. Entwicklung bildbasierter Radiomics-Biomarker für den Humanen Papillomavirus (HPV)-Status beim oropharyngealen Plattenepithelkarzinom (OPSCC) mittels Machine-Learning-Algorithmen Laryngo-Rhino-Otologie 2020, 99: s116. DOI: 10.1055/s-0040-1711657.
  • Assessment of Lymph Node Evaluation in Patients with Clinically Node Negative Merkel Cell Carcinoma of the Head and NeckJacobs D, Park H, Young M, Olino K, Rahmati R, Mehra S, Burtness B, Judson B. Assessment of Lymph Node Evaluation in Patients with Clinically Node Negative Merkel Cell Carcinoma of the Head and Neck International Journal Of Radiation Oncology • Biology • Physics 2020, 106: 1191-1192. DOI: 10.1016/j.ijrobp.2019.11.099.
  • Chapter 11 Trials and tribulations: Clinical trials and the futureKhanna S, Burtness B. Chapter 11 Trials and tribulations: Clinical trials and the future 2020, 197-215. DOI: 10.1016/b978-0-12-820679-9.00011-6.
  • 1127P Brachytherapy and non-cancer mortality in patients with oral cavity and oropharynx SCCsYu J, Tsay C, Sasaki C, Son Y, Decker R, Mehra S, Burtness B. 1127P Brachytherapy and non-cancer mortality in patients with oral cavity and oropharynx SCCs Annals Of Oncology 2019, 30: v457. DOI: 10.1093/annonc/mdz252.019.
  • 1115PD Analysis of efficacy outcomes based on programmed death ligand 1 (PD-L1) scoring techniques in patients with head and neck squamous cell carcinoma (HNSCC) from KEYNOTE-040Cohen E, Harrington K, Soulières D, Le Tourneau C, Licitra L, Burtness B, Bal T, Juco J, Aurora-Garg D, Huang L, Swaby R, Emancipator K. 1115PD Analysis of efficacy outcomes based on programmed death ligand 1 (PD-L1) scoring techniques in patients with head and neck squamous cell carcinoma (HNSCC) from KEYNOTE-040 Annals Of Oncology 2019, 30: v452-v453. DOI: 10.1093/annonc/mdz252.007.
  • 1149P Pathologic staging changes in oral cavity squamous cell carcinoma: Stage migration and implications for adjuvant treatmentHusain Z, Lee N, Eskander A, Park H, mehra S, Burtness B. 1149P Pathologic staging changes in oral cavity squamous cell carcinoma: Stage migration and implications for adjuvant treatment Annals Of Oncology 2019, 30: v466. DOI: 10.1093/annonc/mdz252.041.
  • External Validation and Radiologist Comparison of a Deep Learning Model (DLM) to Identify Extranodal Extension (ENE) in Head and Neck Squamous Cell Carcinoma (HNSCC) with Pretreatment Computed Tomography (CT) ImagingKann B, Hicks D, Payabvash S, Mahajan A, Gupta V, Burtness B, Husain Z, Aneja S. External Validation and Radiologist Comparison of a Deep Learning Model (DLM) to Identify Extranodal Extension (ENE) in Head and Neck Squamous Cell Carcinoma (HNSCC) with Pretreatment Computed Tomography (CT) Imaging International Journal Of Radiation Oncology • Biology • Physics 2019, 105: s71. DOI: 10.1016/j.ijrobp.2019.06.525.
  • Clinical Outcomes of Head and Neck Cancer Patients who Undergo Resection, but Forgo Adjuvant TherapyLoganadane G, Kann B, Park H, Johnson S, Mehra S, Judson B, Bhatia A, Belkacemi Y, Yarbrough W, Burtness B, Husain Z. Clinical Outcomes of Head and Neck Cancer Patients who Undergo Resection, but Forgo Adjuvant Therapy International Journal Of Radiation Oncology • Biology • Physics 2019, 105: e375-e376. DOI: 10.1016/j.ijrobp.2019.06.1628.
  • Protocol-specified final analysis of the phase 3 KEYNOTE-048 trial of pembrolizumab (pembro) as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC).Rischin D, Harrington K, Greil R, Soulieres D, Tahara M, de Castro G, Psyrri A, Baste N, Neupane P, Bratland A, Fuereder T, Hughes B, Mesia R, Ngamphaiboon N, Rordorf T, Wan Ishak W, Zhang Y, Jin F, Gumuscu B, Burtness B. Protocol-specified final analysis of the phase 3 KEYNOTE-048 trial of pembrolizumab (pembro) as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). Journal Of Clinical Oncology 2019, 37: 6000-6000. DOI: 10.1200/jco.2019.37.15_suppl.6000.
  • Alliance A091404: A phase II study of enzalutamide (NSC# 766085) for patients with androgen receptor-positive salivary cancers.Ho A, Foster N, Zoroufy A, Worden F, Price K, Adkins D, Bowles D, Kang H, Burtness B, Sherman E, Morton R, Katabi N, Munster P, Schwartz G. Alliance A091404: A phase II study of enzalutamide (NSC# 766085) for patients with androgen receptor-positive salivary cancers. Journal Of Clinical Oncology 2019, 37: 6020-6020. DOI: 10.1200/jco.2019.37.15_suppl.6020.
  • Pembrolizumab (pembro) for recurrent head and neck squamous cell carcinoma (HNSCC): Post hoc analyses of phase 3 KEYNOTE-040 prior radiation treatment (RT) and disease state.Harrington K, Cohen E, Soulieres D, Dinis J, Licitra L, Ahn M, Soria A, Machiels J, Mach N, Mehra R, Burtness B, Lin J, Cheng J, Swaby R, Le Tourneau C. Pembrolizumab (pembro) for recurrent head and neck squamous cell carcinoma (HNSCC): Post hoc analyses of phase 3 KEYNOTE-040 prior radiation treatment (RT) and disease state. Journal Of Clinical Oncology 2019, 37: 6026-6026. DOI: 10.1200/jco.2019.37.15_suppl.6026.
  • OA01 Impact of Contralateral Lymph Node Involvement on Survival of Surgically-Managed HPV-Positive Oropharyngeal Cancer Staged with the AJCC Eighth EditionMiccio J, Kelly J, Kann B, An Y, Park H, Verma V, Mehra S, Judson B, Burtness B, Husain Z. OA01 Impact of Contralateral Lymph Node Involvement on Survival of Surgically-Managed HPV-Positive Oropharyngeal Cancer Staged with the AJCC Eighth Edition International Journal Of Radiation Oncology • Biology • Physics 2019, 103: e1. DOI: 10.1016/s0360-3016(19)30402-x.
  • Adjuvant External Beam Radiation Therapy for Surgically Resected, Non-Metastatic Anaplastic Thyroid CancerSaeed N, Kelly J, Deshpande H, Bhatia A, Burtness B, Judson B, Mehra S, Osborn H, Yarbrough W, Peter P, Holt E, Decker R, Husain Z, Park H. Adjuvant External Beam Radiation Therapy for Surgically Resected, Non-Metastatic Anaplastic Thyroid Cancer International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e290-e291. DOI: 10.1016/j.ijrobp.2018.07.923.
  • Successful Identification of Head and Neck Cancer (HNC) Nodal Metastasis (NM) and Extranodal Extension (ENE) Using Deep Learning Neural NetworksKann B, Aneja S, Loganadane G, Kelly J, Smith S, Decker R, Yarbrough W, Malhotra A, Burtness B, Husain Z. Successful Identification of Head and Neck Cancer (HNC) Nodal Metastasis (NM) and Extranodal Extension (ENE) Using Deep Learning Neural Networks International Journal Of Radiation Oncology • Biology • Physics 2018, 102: s60. DOI: 10.1016/j.ijrobp.2018.06.169.
  • 1047PD Pembrolizumab for recurrent head and neck squamous cell carcinoma (HNSCC): Post hoc analyses of treatment options from the phase III KEYNOTE-040 trialLe Tourneau C, Cohen E, Harrington K, Dinis J, Licitra L, Ahn M, Soria A, Machiels J, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby R, Soulières D. 1047PD Pembrolizumab for recurrent head and neck squamous cell carcinoma (HNSCC): Post hoc analyses of treatment options from the phase III KEYNOTE-040 trial Annals Of Oncology 2018, 29: viii373-viii374. DOI: 10.1093/annonc/mdy287.003.
  • 1052PD Predictor of effectiveness of treatment intensification on overall survival in head and neck cancer (HNC)Zakeri K, Rotolo F, Lacas B, Vitzthum L, Le Q, Gregoire V, Overgaard J, Tobias J, Zackrisson B, Parmar M, Burtness B, Ghi M, Sanguineti G, O'Sullivan B, Fortpied C, Bourhis J, Shen H, Harris J, Pignon J, Mell L. 1052PD Predictor of effectiveness of treatment intensification on overall survival in head and neck cancer (HNC) Annals Of Oncology 2018, 29: viii375-viii376. DOI: 10.1093/annonc/mdy287.008.
  • 1121TiP KEYNOTE-412: Phase III study of pembrolizumab plus chemoradiation vs chemoradiation alone for locally advanced head and neck squamous cell carcinoma (HNSCC)Machiels J, Licitra L, Tao Y, Yen C, Rischin D, Waldron J, Burtness B, Gregoire V, Agarwala S, Yorio J, Delord J, Aksoy S, Ikeda S, Hong R, Ge J, Brown H, Bidadi B, Siu L. 1121TiP KEYNOTE-412: Phase III study of pembrolizumab plus chemoradiation vs chemoradiation alone for locally advanced head and neck squamous cell carcinoma (HNSCC) Annals Of Oncology 2018, 29: viii398. DOI: 10.1093/annonc/mdy287.078.
  • LBA8_PR KEYNOTE-048: Phase III study of first-line pembrolizumab (P) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC)Burtness B, Harrington K, Greil R, Soulières D, Tahara M, De Castro G, Psyrri A, Rotllan N, Neupane P, Bratland Å, Fuereder T, Hughes B, Mesia R, Ngamphaiboon N, Rordorf T, Ishak W, Roy A, Cheng J, Jin F, Rischin D. LBA8_PR KEYNOTE-048: Phase III study of first-line pembrolizumab (P) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) Annals Of Oncology 2018, 29: viii729. DOI: 10.1093/annonc/mdy424.045.
  • Overview: The Pathobiology of Head and Neck CancerBurtness B, Golemis E. Overview: The Pathobiology of Head and Neck Cancer 2018, 1-5. DOI: 10.1007/978-3-319-78762-6_1.
  • Targeting the ErbB Family in Head and Neck CancerKiseleva A, Beck T, Serebriiskii I, Liu H, Burtness B, Golemis E. Targeting the ErbB Family in Head and Neck Cancer 2018, 7-61. DOI: 10.1007/978-3-319-78762-6_2.
  • P53 in Head and Neck Squamous Cell CarcinomaParameswaran J, Burtness B. P53 in Head and Neck Squamous Cell Carcinoma 2018, 249-274. DOI: 10.1007/978-3-319-78762-6_9.
  • Abstract 5814: Synthetic lethal therapy to overcome resistance to AURKA inhibition in HPV-negative head and neck cancerDeneka A, Einarson M, Lee J, Nikonova A, Burtness B, Golemis E. Abstract 5814: Synthetic lethal therapy to overcome resistance to AURKA inhibition in HPV-negative head and neck cancer Cancer Research 2018, 78: 5814-5814. DOI: 10.1158/1538-7445.am2018-5814.
  • Abstract CT115: Updated survival results of the KEYNOTE-040 study of pembrolizumab vs standard-of-care chemotherapy for recurrent or metastatic head and neck squamous cell carcinomaSoulieres D, Cohen E, Tourneau C, Dinis J, Licitra L, Ahn M, Soria A, Machiels J, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby R, Harrington K. Abstract CT115: Updated survival results of the KEYNOTE-040 study of pembrolizumab vs standard-of-care chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma Cancer Research 2018, 78: ct115-ct115. DOI: 10.1158/1538-7445.am2018-ct115.
  • Abstract CT158: Phase II study of monalizumab, a first-in-class NKG2A monoclonal antibody, in combination with cetuximab in previously treated recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Preliminary assessment of safety and efficacyCohen R, Fayette J, Posner M, Lefebvre G, Bauman J, Salas S, Even C, Seiwert T, Colevas D, Jimeno A, Saada E, Burtness B, André P, Paturel C, Bonnafous C, Soulié A, Tirouvanziam-Martin A, Zerbib R, Boyer-Chammard A. Abstract CT158: Phase II study of monalizumab, a first-in-class NKG2A monoclonal antibody, in combination with cetuximab in previously treated recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Preliminary assessment of safety and efficacy Cancer Research 2018, 78: ct158-ct158. DOI: 10.1158/1538-7445.am2018-ct158.
  • Abstract CT163: KEYNOTE-412: Pembrolizumab plus chemoradiation vs chemoradiation alone for locally advanced head and neck squamous cell carcinomaSiu L, Licitra L, Tao Y, Yen C, Rischin D, Waldron J, Burtness B, Gregoire V, Agarwala S, Yorio J, DeLord J, Aksoy S, Ikeda S, Hong R, Ge J, Brown H, Bidadi B, Machiels J. Abstract CT163: KEYNOTE-412: Pembrolizumab plus chemoradiation vs chemoradiation alone for locally advanced head and neck squamous cell carcinoma Cancer Research 2018, 78: ct163-ct163. DOI: 10.1158/1538-7445.am2018-ct163.
  • Abstract LB-339: Biomarkers predictive of response to pembrolizumab in head and neck cancer (HNSCC)Seiwert T, Haddad R, Bauml J, Weiss J, Pfister D, Gupta S, Mehra R, Gluck I, Kang H, Worden F, Eder J, Tahara M, Burtness B, Liu S, Webber A, Huang L, Mogg R, Cristescu R, Cheng J, Chow L. Abstract LB-339: Biomarkers predictive of response to pembrolizumab in head and neck cancer (HNSCC) Cancer Research 2018, 78: lb-339-lb-339. DOI: 10.1158/1538-7445.am2018-lb-339.
  • Oropharyngeal Cancer: HPV-Positive DiseaseKluwe C, Cmelak A, Burtness B. Oropharyngeal Cancer: HPV-Positive Disease 2018 DOI: 10.1891/9780826137784.0013.
  • Health-related quality of life (HRQoL) of pembrolizumab (pembro) vs standard of care (SOC) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) in KEYNOTE-040.Cohen E, Soulieres D, Le Tourneau C, Dinis J, Licitra L, Ahn M, Soria A, Machiels J, Mach N, Mehra R, Burtness B, Ellison M, Cheng J, Chirovsky D, Swaby R, Harrington K. Health-related quality of life (HRQoL) of pembrolizumab (pembro) vs standard of care (SOC) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) in KEYNOTE-040. Journal Of Clinical Oncology 2018, 36: 6013-6013. DOI: 10.1200/jco.2018.36.15_suppl.6013.
  • Pembrolizumab plus chemoradiation vs chemoradiation alone for locally advanced head and neck squamous cell carcinoma: The phase 3 KEYNOTE-412 study.Machiels J, Licitra L, Tao Y, Yen C, Rischin D, Waldron J, Burtness B, Gregoire V, Agarwala S, Yorio J, Delord J, Aksoy S, Ikeda S, Hong R, Ge J, Brown H, Bidadi B, Siu L. Pembrolizumab plus chemoradiation vs chemoradiation alone for locally advanced head and neck squamous cell carcinoma: The phase 3 KEYNOTE-412 study. Journal Of Clinical Oncology 2018, 36: tps6094-tps6094. DOI: 10.1200/jco.2018.36.15_suppl.tps6094.
  • 96TiP Phase 3 KEYNOTE-412 trial: Pembrolizumab plus chemoradiation (CRT) vs CRT alone for locally advanced head and neck squamous cell carcinoma (LA-HNSCC)Machiels J, Yen C, Licitra L, Rischin D, Waldron J, Burtness B, Gregoire V, Tao Y, Yorio J, Aksoy S, Ikeda S, Hong R, Ge J, Brown H, Bidadi B, Siu L. 96TiP Phase 3 KEYNOTE-412 trial: Pembrolizumab plus chemoradiation (CRT) vs CRT alone for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) Annals Of Oncology 2017, 28: xi28. DOI: 10.1093/annonc/mdx711.077.
  • 373TiP KEYNOTE-412: Phase 3 trial of pembrolizumab plus chemoradiation (CRT) vs CRT alone for locally advanced head and neck squamous cell carcinoma (LA-HNSCC)Yen C, Machiels J, Licitra L, Rischin D, Waldron J, Burtness B, Gregoire V, Tao Y, Yorio J, Aksoy S, Ikeda S, Hong R, Ge J, Brown H, Bidadi B, Siu L. 373TiP KEYNOTE-412: Phase 3 trial of pembrolizumab plus chemoradiation (CRT) vs CRT alone for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) Annals Of Oncology 2017, 28: x110. DOI: 10.1093/annonc/mdx665.036.
  • Evaluation of Pathology-Based Staging for HPV-Associated Squamous Cell Carcinoma of the Oropharynx in a Large National SampleKelly J, An Y, Park H, Yarbrough W, Burtness B, Husain Z. Evaluation of Pathology-Based Staging for HPV-Associated Squamous Cell Carcinoma of the Oropharynx in a Large National Sample International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e347. DOI: 10.1016/j.ijrobp.2017.06.1430.
  • Survival Outcomes Among Human Papillomavirus-Associated Oropharyngeal Squamous Cell Cancer Patients Treated with Upfront Surgery Versus Definitive Chemoradiation TherapyKelly J, An Y, Park H, Yarbrough W, Burtness B, Husain Z. Survival Outcomes Among Human Papillomavirus-Associated Oropharyngeal Squamous Cell Cancer Patients Treated with Upfront Surgery Versus Definitive Chemoradiation Therapy International Journal Of Radiation Oncology • Biology • Physics 2017, 99: s43-s44. DOI: 10.1016/j.ijrobp.2017.06.114.
  • LBA45_PR Pembrolizumab (pembro) vs standard of care (SOC) for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): Phase 3 KEYNOTE-040 trialCohen E, Harrington K, Le Tourneau C, Dinis J, Licitra L, Ahn M, Soria A, Machiels J, Mach N, Mehra R, Burtness B, Wang Y, Tuozzo A, Swaby R, Soulieres D. LBA45_PR Pembrolizumab (pembro) vs standard of care (SOC) for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): Phase 3 KEYNOTE-040 trial Annals Of Oncology 2017, 28: v628. DOI: 10.1093/annonc/mdx440.040.
  • 1105TiP Pembrolizumab plus chemoradiation (CRT) for the treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC): Phase 3 KEYNOTE-412 trialMachiels J, Licitra L, Rischin D, Waldron J, Burtness B, Grégoire V, Shekar T, Brown H, Cheng J, Siu L. 1105TiP Pembrolizumab plus chemoradiation (CRT) for the treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC): Phase 3 KEYNOTE-412 trial Annals Of Oncology 2017, 28: v392. DOI: 10.1093/annonc/mdx374.056.
  • Abstract 4732: Analysis of KRAS variant in a cohort of resected HPV negative HNSCCMufson J, Handorf E, Weidhaas J, Lango M, Burtness B, Golemis E, Ridge J, Mehra R. Abstract 4732: Analysis of KRAS variant in a cohort of resected HPV negative HNSCC Cancer Research 2017, 77: 4732-4732. DOI: 10.1158/1538-7445.am2017-4732.
  • (S027) Hypofractionated Radiotherapy Is associated With Improved Overall Survival Among Patients With Early-Stage Glottic CancerBledsoe T, Park H, Stahl J, Yarbrough W, Burtness B, Decker R, Husain Z. (S027) Hypofractionated Radiotherapy Is associated With Improved Overall Survival Among Patients With Early-Stage Glottic Cancer International Journal Of Radiation Oncology • Biology • Physics 2017, 98: e8-e9. DOI: 10.1016/j.ijrobp.2017.02.063.
  • (S040) The Risk of Level IB Nodal Involvement in Oropharynx Cancer: Guidance for Submandibular Gland Sparing IrradiationLee N, Kelly J, Park H, Yarbrough W, Burtness B, Husain Z. (S040) The Risk of Level IB Nodal Involvement in Oropharynx Cancer: Guidance for Submandibular Gland Sparing Irradiation International Journal Of Radiation Oncology • Biology • Physics 2017, 98: e12. DOI: 10.1016/j.ijrobp.2017.02.076.
  • Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma.Parameswaran J, Lee J, Sandoval-Schaefer T, Koo J, Burtness B. Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma. Journal Of Clinical Oncology 2017, 35: e14105-e14105. DOI: 10.1200/jco.2017.35.15_suppl.e14105.
  • PTEN loss as a predictive biomarker in head and neck squamous cell cancer (HNSCC) patients treated with cetuximab (C).Eze N, Chung C, Neumeister V, Sandoval-Schaefer T, Lee J, Burtness B. PTEN loss as a predictive biomarker in head and neck squamous cell cancer (HNSCC) patients treated with cetuximab (C). Journal Of Clinical Oncology 2017, 35: e17520-e17520. DOI: 10.1200/jco.2017.35.15_suppl.e17520.
  • A randomized phase II pilot study prospectively evaluating treatment for patients based on ERCC1 for advanced/ metastatic esophageal, gastric, or gastroesophageal junction cancer: SWOG S1201.Iqbal S, McDonough S, Lenz H, Ilson D, Burtness B, Nangia C, Barzi A, Schneider C, Liu J, Dotan E, Guthrie K, Hochster H. A randomized phase II pilot study prospectively evaluating treatment for patients based on ERCC1 for advanced/ metastatic esophageal, gastric, or gastroesophageal junction cancer: SWOG S1201. Journal Of Clinical Oncology 2017, 35: 4009-4009. DOI: 10.1200/jco.2017.35.15_suppl.4009.
  • Phase III randomized trial of chemotherapy with or without bevacizumab (B) in patients (pts) with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Survival analysis of E1305, an ECOG-ACRIN Cancer Research Group trial.Argiris A, Li S, Savvides P, Ohr J, Gilbert J, Levine M, Haigentz M, Saba N, Chakravarti A, Ikpeazu C, Schneider C, Pinto H, Forastiere A, Burtness B. Phase III randomized trial of chemotherapy with or without bevacizumab (B) in patients (pts) with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Survival analysis of E1305, an ECOG-ACRIN Cancer Research Group trial. Journal Of Clinical Oncology 2017, 35: 6000-6000. DOI: 10.1200/jco.2017.35.15_suppl.6000.
  • LUX-head and neck 2: Randomized, double-blind, placebo-controlled, phase III trial of afatinib as adjuvant therapy after chemoradiation (CRT) in primary unresected, high/intermediate-risk, squamous cell cancer of the head and neck (HNSCC) patients (pts).Burtness B, Haddad R, Dinis J, Trigo Perez J, Yokota T, Viana L, Romanov I, Vermorken J, Bourhis J, Tahara M, Segalla J, Psyrri A, Vasilevskaya I, Nangia C, Chaves-Conde M, Wang B, Gibson N, Ehrnrooth E, Harrington K, Cohen E. LUX-head and neck 2: Randomized, double-blind, placebo-controlled, phase III trial of afatinib as adjuvant therapy after chemoradiation (CRT) in primary unresected, high/intermediate-risk, squamous cell cancer of the head and neck (HNSCC) patients (pts). Journal Of Clinical Oncology 2017, 35: 6001-6001. DOI: 10.1200/jco.2017.35.15_suppl.6001.
  • Genomic determinants of response to pembrolizumab in head and neck squamous cell carcinoma (HNSCC).Haddad R, Seiwert T, Chow L, Gupta S, Weiss J, Gluck I, Eder J, Burtness B, Tahara M, Keam B, Kang H, Muro K, Albright A, Huang L, Ayers M, Mogg R, Cristescu R, Cheng J, Mehra R. Genomic determinants of response to pembrolizumab in head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2017, 35: 6009-6009. DOI: 10.1200/jco.2017.35.15_suppl.6009.
  • IDO1 as a mechanism of adaptive immune resistance to anti-PD1 monotherapy in HNSCC.Wirth L, Burtness B, Mehra R, Bauman J, Lee J, Smith N, Lefranc-Torres A, Westra W, Bishop J, Faquin W, Lin D, Pai S. IDO1 as a mechanism of adaptive immune resistance to anti-PD1 monotherapy in HNSCC. Journal Of Clinical Oncology 2017, 35: 6053-6053. DOI: 10.1200/jco.2017.35.15_suppl.6053.
  • Assessment of established patient reported outcomes (PROs) instruments measuring toxicities and quality of life (QOL) for patients (pts) with head and neck cancer (HNC) treated on ECOG 1308 and 2399 studies.Cmelak A, Flamand Y, Li S, Marur S, Murphy B, Cella D, Forastiere A, Burtness B. Assessment of established patient reported outcomes (PROs) instruments measuring toxicities and quality of life (QOL) for patients (pts) with head and neck cancer (HNC) treated on ECOG 1308 and 2399 studies. Journal Of Clinical Oncology 2017, 35: 6074-6074. DOI: 10.1200/jco.2017.35.15_suppl.6074.
  • KEYNOTE-412: Pembrolizumab (pembro) in combination with chemoradiation versus chemoradiation alone in locally advanced head and neck squamous cell carcinoma (LA-HNSCC).Machiels J, Licitra L, Rischin D, Waldron J, Burtness B, Gregoire V, Shekar T, Brown H, Cheng J, Siu L. KEYNOTE-412: Pembrolizumab (pembro) in combination with chemoradiation versus chemoradiation alone in locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Journal Of Clinical Oncology 2017, 35: tps6090-tps6090. DOI: 10.1200/jco.2017.35.15_suppl.tps6090.
  • Phase II trial of ribociclib and everolimus in p16 low anaplastic thyroid cancer (ATC).Tawfik B, Gerber D, Burtness B, Hughes R, Myers L, Sumer B, Truelson J, Strom T, Kurian P, Saleem S, Pearson J, Zhu H, Khan S. Phase II trial of ribociclib and everolimus in p16 low anaplastic thyroid cancer (ATC). Journal Of Clinical Oncology 2017, 35: tps6098-tps6098. DOI: 10.1200/jco.2017.35.15_suppl.tps6098.
  • Comparison of Upfront Surgery Versus Chemoradiation for cT1-2 N1-2b Oropharynx Squamous Cell Carcinoma Based on Human Papillomavirus StatusKelly J, Park H, An Y, Decker R, Contessa J, Yarbrough W, Burtness B, Judson B, Husain Z. Comparison of Upfront Surgery Versus Chemoradiation for cT1-2 N1-2b Oropharynx Squamous Cell Carcinoma Based on Human Papillomavirus Status International Journal Of Radiation Oncology • Biology • Physics 2016, 96: e327. DOI: 10.1016/j.ijrobp.2016.06.1451.
  • 950O Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 100 randomized trials and 19,248 patients, on behalf of MACH-NC groupBlanchard P, Landais C, Petit C, Zhang Q, Grégoire V, Tobias J, Burtness B, Ghi M, Janot F, Overgaard J, Wolf G, Lewin F, Hitt R, Corvo R, Budach V, Trotti A, Fortpied C, Hackshaw A, Bourhis J, Pignon J. 950O Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 100 randomized trials and 19,248 patients, on behalf of MACH-NC group Annals Of Oncology 2016, 27: vi328. DOI: 10.1093/annonc/mdw376.02.
  • Effect of Neoadjuvant Chemoradiotherapy on Pathologic Stage and Survival in Patients with Locally Advanced Esophageal CancerL K, B B, A F, RF H, E H, MK G. Effect of Neoadjuvant Chemoradiotherapy on Pathologic Stage and Survival in Patients with Locally Advanced Esophageal Cancer Journal Of Cancer Science And Clinical Oncology 2016, 3 DOI: 10.15744/2394-6520.3.105.
  • Double blind phase III trial of effects of low dose 13-cisretinoic acid on prevention of second primaries in stages I-II head and neck cancer: A trial of the ECOG-ACRIN Cancer Research Group (C0590).Bhatia A, Lee J, Pinto H, Jacobs C, Limburg P, Arusell R, Dunphy E, Khandekar J, Reiner S, Baez-Diaz L, Celano P, Li S, Li Y, Burtness B, Pandya K. Double blind phase III trial of effects of low dose 13-cisretinoic acid on prevention of second primaries in stages I-II head and neck cancer: A trial of the ECOG-ACRIN Cancer Research Group (C0590). Journal Of Clinical Oncology 2016, 34: 1507-1507. DOI: 10.1200/jco.2016.34.15_suppl.1507.
  • Biomarkers and response to pembrolizumab (pembro) in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC).Chow L, Mehra R, Haddad R, Mahipal A, Weiss J, Berger R, Eder J, Burtness B, Tahara M, Keam B, Le D, Muro K, Geva R, Chung H, Lin C, Ayers M, Aurora-Garg D, Lunceford J, Cheng J, Seiwert T. Biomarkers and response to pembrolizumab (pembro) in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). Journal Of Clinical Oncology 2016, 34: 6010-6010. DOI: 10.1200/jco.2016.34.15_suppl.6010.
  • Efficacy and safety of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC): Pooled analyses after long-term follow-up in KEYNOTE-012.Mehra R, Seiwert T, Mahipal A, Weiss J, Berger R, Eder J, Burtness B, Tahara M, Keam B, Le D, Muro K, Geva R, Chung H, Lin C, Meister A, Hille D, Cheng J, Chow L, Haddad R. Efficacy and safety of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC): Pooled analyses after long-term follow-up in KEYNOTE-012. Journal Of Clinical Oncology 2016, 34: 6012-6012. DOI: 10.1200/jco.2016.34.15_suppl.6012.
  • Comprehensive genomic sequencing (CGS) of 90 patient samples of anaplastic thyroid cancer (ATC).Khan S, Ci B, Gerber D, McFadden D, Beg M, Xie Y, Kurian P, Cabanillas M, Busaidy N, Sherman S, Heilmann A, Ross J, Bailey M, Burtness B, Ali S. Comprehensive genomic sequencing (CGS) of 90 patient samples of anaplastic thyroid cancer (ATC). Journal Of Clinical Oncology 2016, 34: 6014-6014. DOI: 10.1200/jco.2016.34.15_suppl.6014.
  • Phase II trial of carboplatin/paclitaxel and cetuximab, followed by carboplatin/paclitaxel/cetuximab and erlotinib, in metastatic or recurrent squamous cell carcinoma of the head and neck.Bhatia A, Mehra R, Khan S, Egleston B, Alpaugh R, Lango M, Ridge J, Burtness B. Phase II trial of carboplatin/paclitaxel and cetuximab, followed by carboplatin/paclitaxel/cetuximab and erlotinib, in metastatic or recurrent squamous cell carcinoma of the head and neck. Journal Of Clinical Oncology 2016, 34: 6027-6027. DOI: 10.1200/jco.2016.34.15_suppl.6027.
  • E3311 trial of transoral surgery for oropharynx cancer: Implementation of a novel surgeon credentialing and quality assurance process.Li S, Ferris R, Holsinger F, Weinstein G, Quon H, Mehra R, Garcia J, Chung C, Gillison M, Wagner L, Ringash J, Lewin J, Mendez E, Ridge J, Richmon J, Magnuson S, Bell R, Smith R, Thomas G, Burtness B. E3311 trial of transoral surgery for oropharynx cancer: Implementation of a novel surgeon credentialing and quality assurance process. Journal Of Clinical Oncology 2016, 34: 6054-6054. DOI: 10.1200/jco.2016.34.15_suppl.6054.
  • Tumor Biomarker Association With Clinical Outcomes in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) Patients (Pts) Treated With Afatinib Versus Methotrexate (MTX): LUX-Head & Neck 1 (LHN1)Cohen E, Licitra L, Burtness B, Fayette J, Gauler T, Clement P, Grau J, del Campo J, Mailliez A, Haddad R, Vermorken J, Tahara M, Guigay J, Geoffrois L, Merlano M, Cong X, Gibson N, Solca F, Ehrnrooth E, Machiels J. Tumor Biomarker Association With Clinical Outcomes in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) Patients (Pts) Treated With Afatinib Versus Methotrexate (MTX): LUX-Head & Neck 1 (LHN1) International Journal Of Radiation Oncology • Biology • Physics 2016, 94: 868-869. DOI: 10.1016/j.ijrobp.2015.12.032.
  • 342TiP Phase 3 trial of pembrolizumab as a first-line treatment in subjects with recurrent/metastatic head and neck squamous cell carcinoma: KEYNOTE-048Yen C, Klochikhin A, Cohen E, Vermorken J, Harrington K, Tahara M, Ge J, Geib J, Jin F, Burtness B. 342TiP Phase 3 trial of pembrolizumab as a first-line treatment in subjects with recurrent/metastatic head and neck squamous cell carcinoma: KEYNOTE-048 Annals Of Oncology 2015, 26: ix93. DOI: 10.1093/annonc/mdv527.29.
  • 314O_PR Second-line afatinib vs methotrexate (MTX) in patients (pts) with recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC): subgroup/biomarker analysis of LUX-head and neck 1 (LUX-H&N1)Tahara M, Cohen E, Haddad R, Fayette J, Licitra L, Clement P, Vermorken J, Gauler T, Cupissol D, Grau J, Guigay J, del Campo J, Okami K, Takahashi S, Burtness B, Cong X, Gibson N, Solca F, Ehrnrooth E, Machiels J. 314O_PR Second-line afatinib vs methotrexate (MTX) in patients (pts) with recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC): subgroup/biomarker analysis of LUX-head and neck 1 (LUX-H&N1) Annals Of Oncology 2015, 26: ix93. DOI: 10.1093/annonc/mdv527.01.
  • 343TiP Pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer: Methodology of phase 3 randomized trialMachiels J, Shin S, Cohen E, Harrington K, Burtness B, Gause C, Swift A, Swaby R, Le Tourneau C. 343TiP Pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer: Methodology of phase 3 randomized trial Annals Of Oncology 2015, 26: ix93. DOI: 10.1093/annonc/mdv527.30.
  • Abstract C172: Concomitant disruption of WEE1 and AurKA synergistically enhances anti-cancer effects in p53 mutated head and neck squamous cell carcinomaLee J, Parameswaran J, Koo J, Burtness B. Abstract C172: Concomitant disruption of WEE1 and AurKA synergistically enhances anti-cancer effects in p53 mutated head and neck squamous cell carcinoma Molecular Cancer Therapeutics 2015, 14: c172-c172. DOI: 10.1158/1535-7163.targ-15-c172.
  • Phase I/II study of ADXS11-001 or MEDI4736 immunotherapies alone and in combination, in patients with recurrent/metastatic cervical or human papillomavirus (HPV)-positive head and neck cancerCohen E, Moore K, Slomovitz B, Chung C, Anderson M, Morris S, Mauro D, Burtness B. Phase I/II study of ADXS11-001 or MEDI4736 immunotherapies alone and in combination, in patients with recurrent/metastatic cervical or human papillomavirus (HPV)-positive head and neck cancer Journal For ImmunoTherapy Of Cancer 2015, 3: p147. PMCID: PMC4645484, DOI: 10.1186/2051-1426-3-s2-p147.
  • 11TiP Phase 3 trial of pembrolizumab as a first-line treatment in subjects with recurrent/metastatic head and neck squamous cell carcinoma: KEYNOTE-048Klochikhin A, Greil R, Cohen E, Vermorken J, Harrington K, Tahara M, Ge J, Geib J, Jin F, Burtness B. 11TiP Phase 3 trial of pembrolizumab as a first-line treatment in subjects with recurrent/metastatic head and neck squamous cell carcinoma: KEYNOTE-048 Annals Of Oncology 2015, 26: viii5. DOI: 10.1093/annonc/mdv514.01.
  • 13TiP Pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer: methodology of phase 3 randomized trialHarrington K, Machiels J, Shin S, Cohen E, Burtness B, Gause C, Swift A, Swaby R, Le Tourneau C. 13TiP Pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer: methodology of phase 3 randomized trial Annals Of Oncology 2015, 26: viii5. DOI: 10.1093/annonc/mdv514.03.
  • 2866 Antitumor activity of the Anti-PD-1 antibody pembrolizumab in subgroups of patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC): Exploratory analyses from KEYNOTE-012Chow L, Mehra R, Haddad R, Gupta S, Weiss J, Berger R, Burtness B, Tahara M, Keam B, Le D, Cheng J, Heath K, Pathiraja K, Seiwert T. 2866 Antitumor activity of the Anti-PD-1 antibody pembrolizumab in subgroups of patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC): Exploratory analyses from KEYNOTE-012 European Journal Of Cancer 2015, 51: s579. DOI: 10.1016/s0959-8049(16)31604-5.
  • Abstract LB-178: Genomic analysis identifies a subset of laryngeal tumors with poor prognosisPeri S, Slifker M, Mehra R, Burtness B, Ross E, Golemis E. Abstract LB-178: Genomic analysis identifies a subset of laryngeal tumors with poor prognosis 2015, lb-178-lb-178. DOI: 10.1158/1538-7445.am2015-lb-178.
  • Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): Preliminary results from KEYNOTE-012 expansion cohort.Seiwert T, Haddad R, Gupta S, Mehra R, Tahara M, Berger R, Lee S, Burtness B, Le D, Heath K, Blum A, Dolled-Filhart M, Emancipator K, Pathiraja K, Cheng J, Chow L. Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): Preliminary results from KEYNOTE-012 expansion cohort. Journal Of Clinical Oncology 2015, 33: lba6008-lba6008. DOI: 10.1200/jco.2015.33.18_suppl.lba6008.
  • Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients.Seiwert T, Burtness B, Weiss J, Eder J, Yearley J, Murphy E, Nebozhyn M, McClanahan T, Ayers M, Lunceford J, Mehra R, Heath K, Cheng J, Chow L. Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients. Journal Of Clinical Oncology 2015, 33: 6017-6017. DOI: 10.1200/jco.2015.33.15_suppl.6017.
  • Symptom reduction from IMRT dose deintensification: Results from ECOG 1308 using the Vanderbilt Head and Neck Symptom Survey version 2 (VHNSS V2).Cmelak A, Li S, Marur S, Zhao W, Westra W, Chung C, Gillison M, Gilbert J, Bauman J, Wagner L, Ferris R, Trevarthen D, Murphy B, Galloway T, Burtness B. Symptom reduction from IMRT dose deintensification: Results from ECOG 1308 using the Vanderbilt Head and Neck Symptom Survey version 2 (VHNSS V2). Journal Of Clinical Oncology 2015, 33: 6021-6021. DOI: 10.1200/jco.2015.33.15_suppl.6021.
  • Safety analysis of a phase III randomized trial of chemotherapy with or without bevacizumab (B) in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN).Argiris A, Li S, Savvides P, Forastiere A, Burtness B. Safety analysis of a phase III randomized trial of chemotherapy with or without bevacizumab (B) in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). Journal Of Clinical Oncology 2015, 33: 6022-6022. DOI: 10.1200/jco.2015.33.15_suppl.6022.
  • Biomarker analysis in recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients (pts) treated with second-line afatinib versus methotrexate (MTX): LUX-Head & Neck 1 (LUX-H&N1).Cohen E, Licitra L, Fayette J, Gauler T, Clement P, Grau J, Del Campo J, Mailliez A, Haddad R, Vermorken J, Tahara M, Guigay J, Geoffrois L, Merlano M, Dupuis N, Burtness B, Gibson N, Solca F, Ehrnrooth E, Machiels J. Biomarker analysis in recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients (pts) treated with second-line afatinib versus methotrexate (MTX): LUX-Head & Neck 1 (LUX-H&N1). Journal Of Clinical Oncology 2015, 33: 6023-6023. DOI: 10.1200/jco.2015.33.15_suppl.6023.
  • Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): Preliminary results from KEYNOTE-012 expansion cohort.Seiwert T, Haddad R, Gupta S, Mehra R, Tahara M, Berger R, Lee S, Burtness B, Le D, Heath K, Blum A, Dolled-Filhart M, Emancipator K, Pathiraja K, Cheng J, Chow L. Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): Preliminary results from KEYNOTE-012 expansion cohort. Journal Of Clinical Oncology 2015, 33: lba6008-lba6008. DOI: 10.1200/jco.2015.33.15_suppl.lba6008.
  • KEYNOTE-040: A phase III randomized trial of pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer.Cohen E, Machiels J, Harrington K, Burtness B, Shin S, Gause C, Swift A, Brown H, Perrone A, Cheng J, Swaby R, Le Tourneau C. KEYNOTE-040: A phase III randomized trial of pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer. Journal Of Clinical Oncology 2015, 33: tps6084-tps6084. DOI: 10.1200/jco.2015.33.15_suppl.tps6084.
  • Ceritinib in anaplastic thyroid cancer (ATC) with ALK abnormalities.Khan S, Bauman J, Burtness B, Frankel A, Harper J, Hughes R, Kurian P, Myers L, Nedzi L, Schwartz D, Sumer B, Truelson J, Zhu H. Ceritinib in anaplastic thyroid cancer (ATC) with ALK abnormalities. Journal Of Clinical Oncology 2015, 33: tps6085-tps6085. DOI: 10.1200/jco.2015.33.15_suppl.tps6085.
  • Abstract 4743: Analysis of a protein expression biomarkers in HPV negative SCCHNMehra R, Yang D, Handorf E, Serebriiskii I, Ross E, Lango M, Ridge J, Golemis E, Burtness B. Abstract 4743: Analysis of a protein expression biomarkers in HPV negative SCCHN 2014, 4743-4743. DOI: 10.1158/1538-7445.am2014-4743.
  • Evaluation of Primary Treatment Technique for Squamous Cell Carcinoma of the Buccal Mucosa: A Single-Center ExperienceScher E, Handorf E, Ridge J, Mehra R, Lango M, Burtness B, Liu J, Galloway T. Evaluation of Primary Treatment Technique for Squamous Cell Carcinoma of the Buccal Mucosa: A Single-Center Experience International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s507. DOI: 10.1016/j.ijrobp.2014.05.1558.
  • LBA31 A Phase Ib Study of Pembrolizumab (Pembro; Mk-3475) in Patients (Pts) with Human Papiilloma Virus (Hpv)-Positive and Negative Head and Neck Cancer (Hnc)Chow L, Burtness B, Weiss J, Berger R, Eder J, Gonzalez E, Pulini J, Johnson J, Dolled-Filhart M, Emancipator K, Lunceford J, Pathiraja K, Gause C, Cheng J, Seiwert T. LBA31 A Phase Ib Study of Pembrolizumab (Pembro; Mk-3475) in Patients (Pts) with Human Papiilloma Virus (Hpv)-Positive and Negative Head and Neck Cancer (Hnc) Annals Of Oncology 2014, 25: v1. DOI: 10.1093/annonc/mdu438.32.
  • E1308: Reduced-dose IMRT in human papilloma virus (HPV)-associated resectable oropharyngeal squamous carcinomas (OPSCC) after clinical complete response (cCR) to induction chemotherapy (IC).Cmelak A, Li S, Marur S, Zhao W, Westra W, Chung C, Gillison M, Gilbert J, Bauman J, Wagner L, Ferris R, Trevarthen D, Colevas A, Jahagirdar B, Burtness B. E1308: Reduced-dose IMRT in human papilloma virus (HPV)-associated resectable oropharyngeal squamous carcinomas (OPSCC) after clinical complete response (cCR) to induction chemotherapy (IC). Journal Of Clinical Oncology 2014, 32: lba6006-lba6006. DOI: 10.1200/jco.2014.32.18_suppl.lba6006.
  • E2208: Randomized phase II study of paclitaxel with or without the anti-IGF-IR antibody cixutumumab (IMC-A12) as second-line treatment for patients with metastatic esophageal or GE junction cancer.Cohen S, Feng Y, Catalano P, Mitchell E, O'Dwyer P, Lubner S, Fisher G, Mulcahy M, Burtness B, Benson A. E2208: Randomized phase II study of paclitaxel with or without the anti-IGF-IR antibody cixutumumab (IMC-A12) as second-line treatment for patients with metastatic esophageal or GE junction cancer. Journal Of Clinical Oncology 2014, 32: 4020-4020. DOI: 10.1200/jco.2014.32.15_suppl.4020.
  • A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV–associated head and neck (H/N) cancer.Seiwert T, Burtness B, Weiss J, Gluck I, Eder J, Pai S, Dolled-Filhart M, Emancipator K, Pathiraja K, Gause C, Iannone R, Brown H, Houp J, Cheng J, Chow L. A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV–associated head and neck (H/N) cancer. Journal Of Clinical Oncology 2014, 32: 6011-6011. DOI: 10.1200/jco.2014.32.15_suppl.6011.
  • Evaluation of computational tools to determine prognostic significance of TP53 mutation in head and neck squamous cell carcinoma (HNSCC).Masica D, Li S, Douville C, Manola J, Ferris R, Burtness B, Forastiere A, Koch W, Karchin R, Chung C. Evaluation of computational tools to determine prognostic significance of TP53 mutation in head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2014, 32: 6035-6035. DOI: 10.1200/jco.2014.32.15_suppl.6035.
  • E1308: Reduced-dose IMRT in human papilloma virus (HPV)-associated resectable oropharyngeal squamous carcinomas (OPSCC) after clinical complete response (cCR) to induction chemotherapy (IC).Cmelak A, Li S, Marur S, Zhao W, Westra W, Chung C, Gillison M, Gilbert J, Bauman J, Wagner L, Ferris R, Trevarthen D, Colevas A, Jahagirdar B, Burtness B. E1308: Reduced-dose IMRT in human papilloma virus (HPV)-associated resectable oropharyngeal squamous carcinomas (OPSCC) after clinical complete response (cCR) to induction chemotherapy (IC). Journal Of Clinical Oncology 2014, 32: lba6006-lba6006. DOI: 10.1200/jco.2014.32.15_suppl.lba6006.
  • Overview: The Pathobiology of Head and Neck CancerBurtness B, Golemis E. Overview: The Pathobiology of Head and Neck Cancer 2014, 1-5. DOI: 10.1007/978-1-4614-8815-6_1.
  • Projections: Novel Therapies for HPV-Negative Cancers of the Head and NeckBurtness B. Projections: Novel Therapies for HPV-Negative Cancers of the Head and Neck 2014, 343-359. DOI: 10.1007/978-1-4614-8815-6_17.
  • HPV Association and the Increasing Incidence of Unknown Primary Head-and-Neck Squamous Cell Carcinoma Epidemiology and PreventionGalloway T, Davis K, Burtness B, Ferris R, Mehra R, Ridge J, Flieder D, Duvvuri U. HPV Association and the Increasing Incidence of Unknown Primary Head-and-Neck Squamous Cell Carcinoma Epidemiology and Prevention International Journal Of Radiation Oncology • Biology • Physics 2014, 88: 494. DOI: 10.1016/j.ijrobp.2013.11.102.
  • Freedom from recurrence after induction cisplatin/5-FU/RT versus carboplatin/paclitaxel/RT in patients with esophageal cancer.Thomay A, Su S, Friedant A, Ruth K, Astsaturov I, Burtness B, Denlinger C, Dotan E, Hall M, Meyer J, Shah P, Cohen S, Scott W. Freedom from recurrence after induction cisplatin/5-FU/RT versus carboplatin/paclitaxel/RT in patients with esophageal cancer. Journal Of Clinical Oncology 2014, 32: 126-126. DOI: 10.1200/jco.2014.32.3_suppl.126.
  • Abstract B268: A Phase I Study of CUDC-101, a multitarget inhibitor of HDACs, EGFR, and HER2, in combination with chemoradiation in patients with intermediate/high risk locally advanced squamous cell carcinoma of the head and neck.Jimeno A, Galloway T, Wirth L, Gilbert J, Saba N, Bauman J, Colevas D, Mehra R, Raben D, Lai C, Laliberte R, Voi M, Burtness B. Abstract B268: A Phase I Study of CUDC-101, a multitarget inhibitor of HDACs, EGFR, and HER2, in combination with chemoradiation in patients with intermediate/high risk locally advanced squamous cell carcinoma of the head and neck. Molecular Cancer Therapeutics 2013, 12: b268-b268. DOI: 10.1158/1535-7163.targ-13-b268.
  • Can It Stay or Should It Go? A Comparison of T4 Laryngeal Cancer ManagementLemons J, Ruth K, Ridge J, Burtness B, Lango M, Mehra R, Liu J, Galloway T. Can It Stay or Should It Go? A Comparison of T4 Laryngeal Cancer Management International Journal Of Radiation Oncology • Biology • Physics 2013, 87: s452. DOI: 10.1016/j.ijrobp.2013.06.1193.
  • E 1308: A phase II trial of induction chemotherapy (IC) followed by cetuximab with low dose versus standard dose IMRT in patients with human papilloma virus (HPV)-associated resectable squamous cell carcinoma of the oropharynx (OPSCC).Marur S, Li S, Cmelak A, Gillison M, Ferris R, Bauman J, Zhao W, Westra W, Chung C, Wagner L, Trevarthen D, Jahagirdar B, Colevas A, Burtness B. E 1308: A phase II trial of induction chemotherapy (IC) followed by cetuximab with low dose versus standard dose IMRT in patients with human papilloma virus (HPV)-associated resectable squamous cell carcinoma of the oropharynx (OPSCC). Journal Of Clinical Oncology 2013, 31: 6005-6005. DOI: 10.1200/jco.2013.31.15_suppl.6005.
  • Analysis of HPV and ERCC1 in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN).Mehra R, Egloff A, Li S, Yang D, Wang L, Zhu F, Forastiere A, Burtness B, Argiris A. Analysis of HPV and ERCC1 in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). Journal Of Clinical Oncology 2013, 31: 6006-6006. DOI: 10.1200/jco.2013.31.15_suppl.6006.
  • Association of the 3'-untranslated region KRAS-variant with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.Weidhaas J, Lee J, Slebos R, Howard J, Perez J, Gilbert J, Nallur S, Paranjape T, Garcia J, Burtness B, Forastiere A, Chung C. Association of the 3'-untranslated region KRAS-variant with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Journal Of Clinical Oncology 2013, 31: 6016-6016. DOI: 10.1200/jco.2013.31.15_suppl.6016.
  • Activity of cetuximab (C) in head and neck squamous cell carcinoma (HNSCC) patients (pts) with PTEN loss or PIK3CA mutation treated on E5397, a phase III trial of cisplatin (CDDP) with placebo (P) or C.Burtness B, Lee J, Yang D, Zhu F, Garcia J, Forastiere A, Chung C. Activity of cetuximab (C) in head and neck squamous cell carcinoma (HNSCC) patients (pts) with PTEN loss or PIK3CA mutation treated on E5397, a phase III trial of cisplatin (CDDP) with placebo (P) or C. Journal Of Clinical Oncology 2013, 31: 6028-6028. DOI: 10.1200/jco.2013.31.15_suppl.6028.
  • Predictive biomarkers in a phase II trial of weekly carboplatin (CBDCA), paclitaxel (P), and cetuximab (C) induction and chemoradiation (CRT) in patients (pts) with resectable stage III/IVa,b head and neck squamous cell carcinoma (HNSCC): Eastern Cooperative Oncology Group E2303.Psyrri A, Lee J, Vasilakopoulou M, Pectasides E, Burtness B, Rimm D, Wanebo H, Forastiere A. Predictive biomarkers in a phase II trial of weekly carboplatin (CBDCA), paclitaxel (P), and cetuximab (C) induction and chemoradiation (CRT) in patients (pts) with resectable stage III/IVa,b head and neck squamous cell carcinoma (HNSCC): Eastern Cooperative Oncology Group E2303. Journal Of Clinical Oncology 2013, 31: 6081-6081. DOI: 10.1200/jco.2013.31.15_suppl.6081.
  • Long-term disease control of ≥2 years achieved with cabozantinib in subjects with metastatic medullary thyroid carcinoma on a phase I study.Cohen E, Hong D, Pfister D, Salgia R, Burtness B, Cohen R, Ball D, Mehra R, Mangeshkar M, Yaron Y, Bentzien F, Kurzrock R. Long-term disease control of ≥2 years achieved with cabozantinib in subjects with metastatic medullary thyroid carcinoma on a phase I study. Journal Of Clinical Oncology 2013, 31: 6090-6090. DOI: 10.1200/jco.2013.31.15_suppl.6090.
  • 445 Modern Chemotherapy Mitigates Adverse Prognostic Effect of Regional Nodal Metastases in Stage IV Colorectal CancerChun Y, Cohen S, Donohue J, Burtness B, Hall M, Nagorney D. 445 Modern Chemotherapy Mitigates Adverse Prognostic Effect of Regional Nodal Metastases in Stage IV Colorectal Cancer Gastroenterology 2013, 144: s-1048. DOI: 10.1016/s0016-5085(13)63901-3.
  • Dysplasia at the Margin? Investigating the Case for Subsequent Therapy in Squamous Cell Carcinoma of the Oral TongueSopka D, Li T, Lango M, Mehra R, Burtness B, Flieder D, Ridge J, Galloway T. Dysplasia at the Margin? Investigating the Case for Subsequent Therapy in Squamous Cell Carcinoma of the Oral Tongue International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s205. DOI: 10.1016/j.ijrobp.2012.07.531.
  • p16 Status, Pathologic and Clinical Characteristics, and Long-term Outcomes in Unknown Primary Carcinomas of the Head and NeckKeller L, Galloway T, Holdbrook T, Flieder D, Ruth K, Lango M, Mehra R, Burtness B, Ridge J. p16 Status, Pathologic and Clinical Characteristics, and Long-term Outcomes in Unknown Primary Carcinomas of the Head and Neck International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s514. DOI: 10.1016/j.ijrobp.2012.07.1370.
  • 59IN Strategies to Optimize EGFR TherapiesBurtness B. 59IN Strategies to Optimize EGFR Therapies Annals Of Oncology 2012, 23: ix42. DOI: 10.1016/s0923-7534(20)32673-9.
  • ECOG 1308: A phase II trial of induction chemotherapy followed by cetuximab with low dose versus standard dose IMRT in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx (OP).Marur S, Lee J, Cmelak A, Zhao W, Westra W, Chung C, Gillison M, Gilbert J, Bauman J, Wagner L, Ferris R, Trevarthen D, Colevas A, Jahagirdar B, Burtness B. ECOG 1308: A phase II trial of induction chemotherapy followed by cetuximab with low dose versus standard dose IMRT in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx (OP). Journal Of Clinical Oncology 2012, 30: 5566-5566. DOI: 10.1200/jco.2012.30.15_suppl.5566.
  • Predictors for response to cetuximab in a prospective clinical trial (E2303) of patients with head and neck squamous cell carcinoma (HNSCC).Psyrri A, Lee J, Pectasides E, Vassilakopoulou M, Burtness B, Rimm D, Wanebo H, Forastiere A. Predictors for response to cetuximab in a prospective clinical trial (E2303) of patients with head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2012, 30: 5576-5576. DOI: 10.1200/jco.2012.30.15_suppl.5576.
  • LUX head and neck 2: A randomized, double-blind, placebo-controlled, phase III study of afatinib as adjuvant therapy after chemoradiation in primarily unresected, clinically high-risk, head and neck cancer patients.Burtness B, Bourhis J, Vermorken J, Dai L, Lind C, Ehrnrooth E, Cohen E. LUX head and neck 2: A randomized, double-blind, placebo-controlled, phase III study of afatinib as adjuvant therapy after chemoradiation in primarily unresected, clinically high-risk, head and neck cancer patients. Journal Of Clinical Oncology 2012, 30: tps5599-tps5599. DOI: 10.1200/jco.2012.30.15_suppl.tps5599.
  • Abstract 714: Survivin expression in patients with resected pancreatic adenocarcinomaKhan S, Yang D, Zhu F, Dubyk C, Tejani M, Cohen S, Hoffman J, Burtness B. Abstract 714: Survivin expression in patients with resected pancreatic adenocarcinoma Cancer Research 2012, 72: 714-714. DOI: 10.1158/1538-7445.am2012-714.
  • Abstract 721: Expression of Aurora A and Phospho-Aurora-A is predictive of survival in patients with head and neck cancerFidler C, Yang D, Zhu F, Mehra R, Astsaturov I, Ridge J, Golemis E, Burtness B. Abstract 721: Expression of Aurora A and Phospho-Aurora-A is predictive of survival in patients with head and neck cancer Cancer Research 2012, 72: 721-721. DOI: 10.1158/1538-7445.am2012-721.
  • A phase I evaluation of vandetanib plus paclitaxel, carboplatin, 5-fluorouracil, and XRT induction therapy followed by surgery for previously untreated locally advanced cancer of the esophagus and GE junction.Astsaturov I, Meyer J, Cheng J, Olszanski A, Dushkin H, Berger A, Davey M, Cohen S, Burtness B, Scott W. A phase I evaluation of vandetanib plus paclitaxel, carboplatin, 5-fluorouracil, and XRT induction therapy followed by surgery for previously untreated locally advanced cancer of the esophagus and GE junction. Journal Of Clinical Oncology 2012, 30: 74-74. DOI: 10.1200/jco.2012.30.4_suppl.74.
  • Effect of increased time from chemoradiation to surgery on the pathologic complete response rate in patients with esophageal cancer.Shaikh T, Ruth K, Scott W, Burtness B, Cohen S, Konski A, Cooper H, Astsaturov I, Meyer J. Effect of increased time from chemoradiation to surgery on the pathologic complete response rate in patients with esophageal cancer. Journal Of Clinical Oncology 2012, 30: 84-84. DOI: 10.1200/jco.2012.30.4_suppl.84.
  • Maximizing the Effect of Neoadjuvant Chemoradiation in Patients with Borderline Resectable Pancreatic CancerSopka D, Chun Y, Cohen S, Zhu F, Milestone B, Cooper H, Freedman G, Burtness B, Hoffman J, Meyer J. Maximizing the Effect of Neoadjuvant Chemoradiation in Patients with Borderline Resectable Pancreatic Cancer International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s335. DOI: 10.1016/j.ijrobp.2011.06.1804.
  • Low Rates of Gastrostomy Tube Dependence in Patients with T1-T2 Oropharynx Cancer Treated without Pharyngeal Constrictor SparingGalloway T, Turaka A, Ruth K, Mehra R, Lango M, Burtness B, Ridge J, Horwitz E. Low Rates of Gastrostomy Tube Dependence in Patients with T1-T2 Oropharynx Cancer Treated without Pharyngeal Constrictor Sparing International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s504. DOI: 10.1016/j.ijrobp.2011.06.1029.
  • ERCC1 and RRM1 expression in resected pancreatic adenocarcinoma.Tejani M, Cai K, Zhu F, Dubyk C, Chun Y, Cohen S, Hoffman J, Burtness B. ERCC1 and RRM1 expression in resected pancreatic adenocarcinoma. Journal Of Clinical Oncology 2011, 29: e14606-e14606. DOI: 10.1200/jco.2011.29.15_suppl.e14606.
  • p16 protein status and response to treatment in a prospective clinical trial (ECOG 2303) of patients with head and neck squamous cell carcinoma (HNSCC).Psyrri A, Ghebremichael M, Pectasides E, Dimou A, Burtness B, Rimm D, Wanebo H, Forastiere A. p16 protein status and response to treatment in a prospective clinical trial (ECOG 2303) of patients with head and neck squamous cell carcinoma (HNSCC). Journal Of Clinical Oncology 2011, 29: e16032-e16032. DOI: 10.1200/jco.2011.29.15_suppl.e16032.
  • Abstract 2254: Nuclear and cytoplasmic epidermal growth factor receptor and p16 expression as prognostic biomarkers in head and neck squamous cell carcinomaHusain H, Psyrri A, Slebos R, Ross D, Burtness B, Chung C. Abstract 2254: Nuclear and cytoplasmic epidermal growth factor receptor and p16 expression as prognostic biomarkers in head and neck squamous cell carcinoma Cancer Research 2011, 71: 2254-2254. DOI: 10.1158/1538-7445.am2011-2254.
  • Antibody-Based Therapies for Solid TumorsShanbhag S, Burtness B. Antibody-Based Therapies for Solid Tumors 2010, 245-256. DOI: 10.1007/978-90-481-9704-0_13.
  • Intensity Modulated Radiation Therapy (IMRT) for the Para-nasal Sinus (PNS) MalignanciesRichard C, Turaka A, Li T, Nicolaou N, Horwitz E, Lango M, Burtness B, Ridge J, Feigenberg S. Intensity Modulated Radiation Therapy (IMRT) for the Para-nasal Sinus (PNS) Malignancies International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s478-s479. DOI: 10.1016/j.ijrobp.2010.07.1122.
  • SU‐GG‐T‐178: Intensity‐Modulated Radiation Therapy (IMRT) in the Treatment of Oropharyngeal Carcinoma: Clinical Outcomes and Relation of Parotid Gland Volume with XerostomiaTuraka A, Weinberg B, Li T, Nicos N, Burtness B, Lango M, Ridge J, Feigenberg S. SU‐GG‐T‐178: Intensity‐Modulated Radiation Therapy (IMRT) in the Treatment of Oropharyngeal Carcinoma: Clinical Outcomes and Relation of Parotid Gland Volume with Xerostomia Medical Physics 2010, 37: 3226-3226. DOI: 10.1118/1.3468568.
  • SU‐GG‐T‐180: Intensity‐Modulated Radiation Therapy (IMRT) for the Para‐Nasal Sinus (PNS) Malignancies: Outcomes from Fox Chase Cancer Center (FCCC)Turaka A, Cattaneo R, Nicos N, Lango M, Burtness B, Ridge J, Feigenberg S. SU‐GG‐T‐180: Intensity‐Modulated Radiation Therapy (IMRT) for the Para‐Nasal Sinus (PNS) Malignancies: Outcomes from Fox Chase Cancer Center (FCCC) Medical Physics 2010, 37: 3226-3226. DOI: 10.1118/1.3468570.
  • CALGB 80403/ECOG 1206: A randomized phase II study of three standard chemotherapy regimens (ECF, IC, FOLFOX) plus cetuximab in metastatic esophageal and GE junction cancer.Enzinger P, Burtness B, Hollis D, Niedzwiecki D, Ilson D, Benson A, Mayer R, Goldberg R. CALGB 80403/ECOG 1206: A randomized phase II study of three standard chemotherapy regimens (ECF, IC, FOLFOX) plus cetuximab in metastatic esophageal and GE junction cancer. Journal Of Clinical Oncology 2010, 28: 4006-4006. DOI: 10.1200/jco.2010.28.15_suppl.4006.
  • Phase II induction cetuximab (C225), paclitaxel (P), and carboplatin (C) followed by chemoradiation with C225, P, C, and RT 68-72Gy for stage III/IV head and neck squamous cancer: Primary site organ preservation and disease control at 2 years (ECOG, E2303).Wanebo H, Ghebremichael M, Burtness B, Ridge J, Spencer S, Rosen F, Hancock M, Tolba K, Forastiere A. Phase II induction cetuximab (C225), paclitaxel (P), and carboplatin (C) followed by chemoradiation with C225, P, C, and RT 68-72Gy for stage III/IV head and neck squamous cancer: Primary site organ preservation and disease control at 2 years (ECOG, E2303). Journal Of Clinical Oncology 2010, 28: 5513-5513. DOI: 10.1200/jco.2010.28.15_suppl.5513.
  • Tumor molecular correlates of unresectable, locally advanced head and neck squamous cell carcinoma (SCCHN) response to concurrent radiation (RT), cisplatin (DDP), and cetuximab (C225) in a phase II trial (ECOG 3303).Egloff A, Lee J, Vaezi A, Langer C, Forastiere A, Quon H, Burtness B, Grandis J. Tumor molecular correlates of unresectable, locally advanced head and neck squamous cell carcinoma (SCCHN) response to concurrent radiation (RT), cisplatin (DDP), and cetuximab (C225) in a phase II trial (ECOG 3303). Journal Of Clinical Oncology 2010, 28: 5537-5537. DOI: 10.1200/jco.2010.28.15_suppl.5537.
  • Evaluation of the incidence and prognostic value of mutant epidermal growth factor receptor (EGFRvIII) protein expression in head and neck squamous cell carcinomas (HNSCC) using AQUA.Pectasides E, Fountzilas G, Kountourakis P, Gouveris P, Sasaki C, Duffey D, Rimm D, Burtness B, Psyrri D. Evaluation of the incidence and prognostic value of mutant epidermal growth factor receptor (EGFRvIII) protein expression in head and neck squamous cell carcinomas (HNSCC) using AQUA. Journal Of Clinical Oncology 2010, 28: 5538-5538. DOI: 10.1200/jco.2010.28.15_suppl.5538.
  • Analysis of ERCC1 (excision repair cross complementing group 1) in squamous cell carcinoma of the head and neck (SCCHN) by quantitative immunohistochemistry (IHC) using FL297.Mehra R, Cai K, Zhu F, Weaver J, Nicolaou N, Cohen R, Lango M, Ridge J, Godwin A, Burtness B. Analysis of ERCC1 (excision repair cross complementing group 1) in squamous cell carcinoma of the head and neck (SCCHN) by quantitative immunohistochemistry (IHC) using FL297. Journal Of Clinical Oncology 2010, 28: 5539-5539. DOI: 10.1200/jco.2010.28.15_suppl.5539.
  • The prognostic value of STAT3 protein in patients with head and neck squamous cell carcinoma (HNSCC) harboring PTEN loss.Fountzilas G, Pectasides E, Kountourakis P, Gouveris P, Sasaki C, Duffey D, Pectasides D, Rimm D, Burtness B, Psyrri D. The prognostic value of STAT3 protein in patients with head and neck squamous cell carcinoma (HNSCC) harboring PTEN loss. Journal Of Clinical Oncology 2010, 28: 5550-5550. DOI: 10.1200/jco.2010.28.15_suppl.5550.
  • Abstract 2804: ERCC1 (excision repair cross complementing group 1) is a predictive biomarker of survival in squamous cell carcinoma of the head and neck (SCCHN)Mehra R, Cai K, Zhu F, Weaver J, Nicolaou N, Lango M, Ridge J, Godwin A, Burtness B. Abstract 2804: ERCC1 (excision repair cross complementing group 1) is a predictive biomarker of survival in squamous cell carcinoma of the head and neck (SCCHN) Cancer Research 2010, 70: 2804-2804. DOI: 10.1158/1538-7445.am10-2804.
  • The use of a Low Neck Field (LNF) and Intensity-Modulated Radiation Therapy (IMRT): No Clinical Detriment of IMRT to an Anterior LNF during the Treatment of Head and Neck CancerTuraka A, Li T, Nicolaou N, Lango M, Burtness B, Horwitz E, Ridge J, Feigenberg S. The use of a Low Neck Field (LNF) and Intensity-Modulated Radiation Therapy (IMRT): No Clinical Detriment of IMRT to an Anterior LNF during the Treatment of Head and Neck Cancer International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s427-s428. DOI: 10.1016/j.ijrobp.2009.07.978.
  • Initial Results of a Phase I Dose Escalation Trial of Concurrent and Maintenance Erlotinib and Re-irradiation for Recurrent and New Primary Head and Neck CancerRusthoven K, Feigenberg S, Raben D, Kane M, Song J, Nicolaou N, Mehra R, Burtness B, Swing R, Chen C. Initial Results of a Phase I Dose Escalation Trial of Concurrent and Maintenance Erlotinib and Re-irradiation for Recurrent and New Primary Head and Neck Cancer International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s408. DOI: 10.1016/j.ijrobp.2009.07.935.
  • A phase III randomized, placebo-controlled trial of docetaxel (D) with or without gefitinib (G) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): A trial of the Eastern Cooperative Oncology Group (ECOG)Argiris A, Ghebremichael M, Gilbert J, Burtness B, Forastiere A. A phase III randomized, placebo-controlled trial of docetaxel (D) with or without gefitinib (G) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): A trial of the Eastern Cooperative Oncology Group (ECOG) Journal Of Clinical Oncology 2009, 27: 6011-6011. DOI: 10.1200/jco.2009.27.15_suppl.6011.
  • Phase II randomized trial of bortezomib (B) plus irinotecan (I) or B with addition of I at progression in recurrent (R) or metastatic (M) squamous cell carcinoma of the head and neck (SCCHN) (E1304): A trial of the Eastern Cooperative Oncology GroupGilbert J, Lee J, Argiris A, Feldman L, Haigentz M, Burtness B, Forastiere A. Phase II randomized trial of bortezomib (B) plus irinotecan (I) or B with addition of I at progression in recurrent (R) or metastatic (M) squamous cell carcinoma of the head and neck (SCCHN) (E1304): A trial of the Eastern Cooperative Oncology Group Journal Of Clinical Oncology 2009, 27: 6020-6020. DOI: 10.1200/jco.2009.27.15_suppl.6020.
  • Outcome and molecular features of head and neck squamous cell carcinomas (HNSCC) bearing a p16 high phenotypePsyrri D, Pectasides E, Weinberger P, Sasaki C, Burtness B, Fountzilas G. Outcome and molecular features of head and neck squamous cell carcinomas (HNSCC) bearing a p16 high phenotype Journal Of Clinical Oncology 2009, 27: 6031-6031. DOI: 10.1200/jco.2009.27.15_suppl.6031.
  • Phase II study of pemetrexed (P) and gemcitabine (G) in patients with advanced head and neck cancer (SCCHN)Mehra R, Sherman E, Ruth K, Litwin S, Sylvester J, Tuttle H, Burtness B, Cohen R, Langer C. Phase II study of pemetrexed (P) and gemcitabine (G) in patients with advanced head and neck cancer (SCCHN) Journal Of Clinical Oncology 2009, 27: 6052-6052. DOI: 10.1200/jco.2009.27.15_suppl.6052.
  • Assessment of phosphatidylinositol-3 kinase (PI3K) as a prognostic marker in head and neck squamous cell carcinoma (HNSCC)Pectasides E, Founztilas G, Sasaki C, Burtness B, Psyrri A. Assessment of phosphatidylinositol-3 kinase (PI3K) as a prognostic marker in head and neck squamous cell carcinoma (HNSCC) Journal Of Clinical Oncology 2009, 27: e17028-e17028. DOI: 10.1200/jco.2009.27.15_suppl.e17028.
  • 246 INVITED Targeting Her: Can resistance to EGFR inhibitors be overcome?Burtness B, Weiner L, Astsaturov I, Golemis E. 246 INVITED Targeting Her: Can resistance to EGFR inhibitors be overcome? European Journal Of Cancer Supplements 2008, 6: 80. DOI: 10.1016/s1359-6349(08)72178-5.
  • Phase II ECOG trial of irinotecan/docetaxel with or without cetuximab in metastatic pancreatic cancer: Updated survival and CA19–9 resultsBurtness B, Powell M, Berlin J, Liles D, Chapman A, Mitchell E, Benson A. Phase II ECOG trial of irinotecan/docetaxel with or without cetuximab in metastatic pancreatic cancer: Updated survival and CA19–9 results Journal Of Clinical Oncology 2008, 26: 4642-4642. DOI: 10.1200/jco.2008.26.15_suppl.4642.
  • Regulation of cytoplasmic and nuclear PTEN levels by human papillomavirus (HPV) type 16 E6 and E7 oncogenes in HPV16+ oropharyngeal cancer cell linePsyrri A, Sasaki C, Burtness B, Rampias T. Regulation of cytoplasmic and nuclear PTEN levels by human papillomavirus (HPV) type 16 E6 and E7 oncogenes in HPV16+ oropharyngeal cancer cell line Journal Of Clinical Oncology 2008, 26: 6034-6034. DOI: 10.1200/jco.2008.26.15_suppl.6034.
  • Molecular prognostic markers in squamous cell carcinoma of the head and neck: the role of E-cadherinKountourakis P, Pectasides E, Burtness B, Pectasides D, Psyrri A, Fountzilas G. Molecular prognostic markers in squamous cell carcinoma of the head and neck: the role of E-cadherin Journal Of Clinical Oncology 2008, 26: 6040-6040. DOI: 10.1200/jco.2008.26.15_suppl.6040.
  • E2399: Correlation of objective and self report measures of swallowing function after concurrent chemoradiation (CCR) for head and neck cancer (HNC)Murphy B, Dietrich M, Cmelak A, Burtness B, Forastiere A. E2399: Correlation of objective and self report measures of swallowing function after concurrent chemoradiation (CCR) for head and neck cancer (HNC) Journal Of Clinical Oncology 2008, 26: 6022-6022. DOI: 10.1200/jco.2008.26.15_suppl.6022.
  • Evaluation of the prognostic significance of activated STAT3 expression levels in head and neck squamous cell carcinoma (HNSCC)Pectasides E, Kountourakis P, Fountzilas G, Burtness B, Psyrri A. Evaluation of the prognostic significance of activated STAT3 expression levels in head and neck squamous cell carcinoma (HNSCC) Journal Of Clinical Oncology 2008, 26: 6015-6015. DOI: 10.1200/jco.2008.26.15_suppl.6015.
  • Gene expression differences associated with silencing of E6 and E7 viral oncogenes in HPV16 + oropharyngeal cancer cell linesRampias T, Sasaki C, Burtness B, Psyrri A. Gene expression differences associated with silencing of E6 and E7 viral oncogenes in HPV16 + oropharyngeal cancer cell lines Journal Of Clinical Oncology 2008, 26: 6009-6009. DOI: 10.1200/jco.2008.26.15_suppl.6009.
  • Correlates and determinants of nuclear epidermal growth factor receptor (EGFR) content in an oropharyngeal cancer tissue microarrayPsyrri A, Weinberger P, Yu Z, Sasaki C, Haffty B, Kowalski D, Burtness B. Correlates and determinants of nuclear epidermal growth factor receptor (EGFR) content in an oropharyngeal cancer tissue microarray Journal Of Clinical Oncology 2007, 25: 6022-6022. DOI: 10.1200/jco.2007.25.18_suppl.6022.
  • Gene copy number of epidermal growth factor receptor (EGFR) by fluorescent in situ hybridization (FISH) in head and neck squamous cell carcinomas (HNSCC) is closely correlated with EGFR protein levels assessed by automated quantitative protein analysis (AQUA)Weinberger P, Psyrri A, Kountourakis P, Rampias T, Sasaki C, Sasaki C, Haffty B, Kowalski D, Fountzilas G, Rimm D, Burtness B. Gene copy number of epidermal growth factor receptor (EGFR) by fluorescent in situ hybridization (FISH) in head and neck squamous cell carcinomas (HNSCC) is closely correlated with EGFR protein levels assessed by automated quantitative protein analysis (AQUA) Journal Of Clinical Oncology 2007, 25: 6023-6023. DOI: 10.1200/jco.2007.25.18_suppl.6023.
  • Phase II trial of irinotecan/docetaxel for advanced pancreatic cancer with randomization between irinotecan/docetaxel and irinotecan/docetaxel plus C225, a monoclonal antibody to the epidermal growth factor receptor (EGF-r) : Eastern Cooperative OncologyBurtness B, Powell M, Berlin J, Liles D, Chapman A, Mitchell E, Benson A. Phase II trial of irinotecan/docetaxel for advanced pancreatic cancer with randomization between irinotecan/docetaxel and irinotecan/docetaxel plus C225, a monoclonal antibody to the epidermal growth factor receptor (EGF-r) : Eastern Cooperative Oncology Journal Of Clinical Oncology 2007, 25: 4519-4519. DOI: 10.1200/jco.2007.25.18_suppl.4519.
  • Phase II evaluation of cetuximab (C225) combined with induction paclitaxel and carboplatin followed by C225, paclitaxel, carboplatin, and radiation for stage III/IV operable squamous cancer of the head and neck (ECOG, E2303)Wanebo H, Ghebremichael M, Burtness B, Spencer S, Ridge J, Forastiere A, Ghebremichael M. Phase II evaluation of cetuximab (C225) combined with induction paclitaxel and carboplatin followed by C225, paclitaxel, carboplatin, and radiation for stage III/IV operable squamous cancer of the head and neck (ECOG, E2303) Journal Of Clinical Oncology 2007, 25: 6015-6015. DOI: 10.1200/jco.2007.25.18_suppl.6015.
  • EGFR expression by immunohistochemistry (IHC) and response to chemotherapy and cetuximab in squamous cell carcinoma of the head and neck (SCCHN)Kies M, Ghebremichael M, Katz T, Herbst R, Youssoufian H, Burtness B. EGFR expression by immunohistochemistry (IHC) and response to chemotherapy and cetuximab in squamous cell carcinoma of the head and neck (SCCHN) Journal Of Clinical Oncology 2007, 25: 6024-6024. DOI: 10.1200/jco.2007.25.18_suppl.6024.
  • 632 POSTER Randomized phase II study of BMS-247550 (NSC 710428) given daily X 5 days or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck: E2301Burtness B, Manola J, Argiris A, Altieri D, Axelrod R, Forastiere A. 632 POSTER Randomized phase II study of BMS-247550 (NSC 710428) given daily X 5 days or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck: E2301 European Journal Of Cancer Supplements 2006, 4: 190-191. DOI: 10.1016/s1359-6349(06)70637-1.
  • 2111 ECOG 1200: A Randomized Phase II Trial of Gemcitabine Plus Radiotherapy vs Gemcitabine, 5-Fluorouracil and Cisplatin Followed by Radiotherapy and 5-Fluorouracil in Patients With Locally Advanced, Potentially Resectable Pancreatic AdenocarcinomaLandry J, Catalano P, Hoffman J, Staley C, Harris W, Burtness B, Frontiera M, Berlin J, Benson A. 2111 ECOG 1200: A Randomized Phase II Trial of Gemcitabine Plus Radiotherapy vs Gemcitabine, 5-Fluorouracil and Cisplatin Followed by Radiotherapy and 5-Fluorouracil in Patients With Locally Advanced, Potentially Resectable Pancreatic Adenocarcinoma International Journal Of Radiation Oncology • Biology • Physics 2006, 66: s272. DOI: 10.1016/j.ijrobp.2006.07.515.
  • Neoadjuvant dose-dense (DD) concurrent doxorubicin (A) and docetaxel (T) for stage III breast cancer (BC)Abu-Khalaf M, Kim R, Cohenuram M, Chung G, Digiovanna M, Haffty B, Carter D, Horvath L, Tavassoli F, Burtness B. Neoadjuvant dose-dense (DD) concurrent doxorubicin (A) and docetaxel (T) for stage III breast cancer (BC) Journal Of Clinical Oncology 2006, 24: 10721-10721. DOI: 10.1200/jco.2006.24.18_suppl.10721.
  • Hepatic metastasectomy following FOLFOX therapy in patients with colorectal metastasesArciero C, Salem R, Lacy J, Sigurdson E, Hoffman J, Watson J, Joseph N, Cooper H, Meropol N, Burtness B. Hepatic metastasectomy following FOLFOX therapy in patients with colorectal metastases Journal Of Clinical Oncology 2006, 24: 13523-13523. DOI: 10.1200/jco.2006.24.18_suppl.13523.
  • A randomized phase II study of BMS-247550 (ixabepilone) given daily x 5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neckBurtness B, Goldwasser M, Axelrod R, Argiris A, Forastiere A. A randomized phase II study of BMS-247550 (ixabepilone) given daily x 5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck Journal Of Clinical Oncology 2006, 24: 5532-5532. DOI: 10.1200/jco.2006.24.18_suppl.5532.
  • A phase II trial of PS-341 (bortezomib) followed by the addition of doxorubicin at progression in incurable adenoid cystic carcinoma of the head and neck: An Eastern Cooperative Oncology Group studyArgiris A, Goldwasser M, Burtness B, Deconti R, Axelrod R, Van Waes C, Forastiere A. A phase II trial of PS-341 (bortezomib) followed by the addition of doxorubicin at progression in incurable adenoid cystic carcinoma of the head and neck: An Eastern Cooperative Oncology Group study Journal Of Clinical Oncology 2006, 24: 5573-5573. DOI: 10.1200/jco.2006.24.18_suppl.5573.
  • Analysis of epidermal growth factor receptor (EGFR) pathway in oropharyngeal squamous cell cancer patients in vivo (OSCC)Psyrri A, Yu Z, Haffty B, Sasaki C, Weinberger P, Camp R, Rimm D, Burtness B. Analysis of epidermal growth factor receptor (EGFR) pathway in oropharyngeal squamous cell cancer patients in vivo (OSCC) Journal Of Clinical Oncology 2005, 23: 5518-5518. DOI: 10.1200/jco.2005.23.16_suppl.5518.
  • Molecular prognostic markers in oropharyngeal squamous cell carcinoma: The role of phospho-AktYu Z, Weinberger P, Sasaki C, Haffty B, Camp R, Rimm D, Burtness B, Psyrri A. Molecular prognostic markers in oropharyngeal squamous cell carcinoma: The role of phospho-Akt Journal Of Clinical Oncology 2005, 23: 5517-5517. DOI: 10.1200/jco.2005.23.16_suppl.5517.
  • Phase II trial of docetaxel/irinotecan therapy in metastatic esophageal cancer: evidence for activity in previously untreated patientsBurtness B, Gibson M, Lacy J, Rowen E, Thomas L, Sipples R, McGurk M, Murren J, Forastiere A. Phase II trial of docetaxel/irinotecan therapy in metastatic esophageal cancer: evidence for activity in previously untreated patients Journal Of Clinical Oncology 2005, 23: 4070-4070. DOI: 10.1200/jco.2005.23.16_suppl.4070.
  • Effect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancerGibson M, Burtness B, Heath E, Heitmiller R, Forastiere A. Effect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancer Journal Of Clinical Oncology 2004, 22: 4032-4032. DOI: 10.1200/jco.2004.22.14_suppl.4032.
  • Phase II trial of irinotecan/docetaxel combination for advanced pancreatic cancerBurtness B, Sipples R, Mirto G, Thomas L, Rahman Z, Kloss R, Murren J, Lacy J. Phase II trial of irinotecan/docetaxel combination for advanced pancreatic cancer Journal Of Clinical Oncology 2004, 22: 4116-4116. DOI: 10.1200/jco.2004.22.14_suppl.4116.
  • Effect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancerGibson M, Burtness B, Heath E, Heitmiller R, Forastiere A. Effect of neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancer Journal Of Clinical Oncology 2004, 22: 4032-4032. DOI: 10.1200/jco.2004.22.90140.4032.
  • Phase II trial of irinotecan/docetaxel combination for advanced pancreatic cancerBurtness B, Sipples R, Mirto G, Thomas L, Rahman Z, Kloss R, Murren J, Lacy J. Phase II trial of irinotecan/docetaxel combination for advanced pancreatic cancer Journal Of Clinical Oncology 2004, 22: 4116-4116. DOI: 10.1200/jco.2004.22.90140.4116.
  • Chapter 23 Neoplastic DiseasesBurtness B. Chapter 23 Neoplastic Diseases 2004, 479-504. DOI: 10.1016/b978-0-7216-0435-0.50027-4.
  • Head and Neck CancerBurtness B. Head and Neck Cancer 2002, 339-346. DOI: 10.1016/b0-12-227555-1/00096-4.
  • Mature survival results with preoperative cisplatin, protracted infusion 5-FU, and 45 GY radiotherapy for esophageal cancerKleinberg L, Knisely J, Heitmiller R, Zahurak M, Yang S, Salem R, Heath E, Burtness B, Forastiere A. Mature survival results with preoperative cisplatin, protracted infusion 5-FU, and 45 GY radiotherapy for esophageal cancer International Journal Of Radiation Oncology • Biology • Physics 2001, 51: 32. DOI: 10.1016/s0360-3016(01)01880-6.
  • Weekly chemotherapy with irinotecan plus a taxane in advanced non small cell lung cancer (NSCLC)Rich R, Argiris A, Peccerillo K, McKeon A, Gallipoli M, Burtness B, Murren J. Weekly chemotherapy with irinotecan plus a taxane in advanced non small cell lung cancer (NSCLC) Lung Cancer 2000, 29: 6. DOI: 10.1016/s0169-5002(00)80014-8.
  • The maximum negative binomial distributionZhang Z, Burtness B, Zelterman D. The maximum negative binomial distribution Journal Of Statistical Planning And Inference 2000, 87: 1-19. DOI: 10.1016/s0378-3758(99)00177-9.
  • 83 Long term local control and survival with preoperative cisplatin, continuous infusion 5-FU, and 45 Gy radiotherapy for esophageal cancerKleinberg L, Knisley J, Heitmiller R, Yang S, Zahurak M, Salem R, Burtness B, Heath E, Forastiere A. 83 Long term local control and survival with preoperative cisplatin, continuous infusion 5-FU, and 45 Gy radiotherapy for esophageal cancer International Journal Of Radiation Oncology • Biology • Physics 1999, 45: 189-190. DOI: 10.1016/s0360-3016(99)90101-3.
  • 2036 The natural history of local regional breast cancer recurrence: Prognosis and implications for systemic therapyHaffty B, Burtness B, Papac R, Marsh J, Ward B, Farber L, Reiss M. 2036 The natural history of local regional breast cancer recurrence: Prognosis and implications for systemic therapy International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 258. DOI: 10.1016/s0360-3016(97)80804-8.

Clinical Trials

ConditionsStudy Title
Larynx; Lip, Oral Cavity and PharynxThe BURAN Study of Buparlisib (AN2025) In Combination With Paclitaxel Compared to Paclitaxel Alone, in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Larynx; Lip, Oral Cavity and PharynxA Randomized, Double-Blind Placebo-Controlled, Phase 3 Study of Debio 1143 in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)
Larynx; Lip, Oral Cavity and PharynxA Phase II Randomized Trial of Adjuvant Therapy With Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma With High Risk Features
Larynx; Lip, Oral Cavity and PharynxA Phase 2, Randomized, Open-label Three-arm Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) That Have Progressed After Platinum Therapy and Immunotherapy (PD-1/PD-L1 Inhibitors) (LEAP-009)
Phase IA Phase 1, First-in-human Study of the Safety, Single- and Multiple-Dose Pharmacokinetics, and Preliminary Activity of Escalating Doses of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors
Corpus Uteri; Larynx; Lung; Soft Tissue; Unknown SitesA Phase 2 Open Label Study of Sacituzumab Govitecan (IMMU-132) in Subjects With Metastatic Solid Tumors
Esophagus; Larynx; Lip, Oral Cavity and Pharynx; Thyroid; Phase IA Phase 1, First-in-Human, Open-Label, Dose Escalation and Expansion Study of CUE-101 Monotherapy in Patients With HPV+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
Esophagus; Larynx; Lip, Oral Cavity and PharynxA Phase II/III Randomized Study of Maintenance Nivolumab Versus Observation in Patients With Locally Advanced, Intermediate Risk HPV Positive OPCA
Other SkinA Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants With High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630)
Larynx; Lip, Oral Cavity and PharynxSingle-Arm Phase II Trial of Dual Inhibition of EGFR With Afatinib and Cetuximab With Correlative Studies in the Second-Line Treatment of Recurrent or Metastatic Squamous Cell Cancers of the Head and Neck
Larynx; Lip, Oral Cavity and PharynxPhase II Randomized Trial of Adjuvant Radiotherapy With or Without Cisplatin for p53 Mutated, Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Larynx; Lip, Oral Cavity and PharynxRadiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer
Lip, Oral Cavity and PharynxIndividualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
Lip, Oral Cavity and PharynxA Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers
Larynx; Lip, Oral Cavity and PharynxA Phase 1b/2 Study of the Combination of Pepinemab and Pembrolizumab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck