Sathish Ramakrishnan, PhD

Dr. Ramakrishnan is an Assistant Professor of Pathology at Yale School of Medicine. His laboratory focuses on understanding the cellular and molecular mechanisms of fusion proteins, which mediate a wide range of cellular processes, including hormone and neurotransmitter release, cell growth, cytokinesis, cancer signaling, progression, and onset. He and his colleagues quantitively dissect the role of SNAREs, and their regulators in normal and diseased conditions using engineered suspended lipid bilayer platforms and single-molecule imaging methods. Understanding the key players of exocytosis can drive therapeutic discovery by clarifying which proteins are critical for each step in the signaling pathway and block the disease progression.