Frederic Pincet, PhD
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2026
Molecular Flexibility and Electrostatic Interactions Drive the Nanoscale Structure of Coiled-Coil GM130 Protein Condensates
Mateos-Gil P, Feito A, Cava D, Tejedor A, Almendro-Vedia V, Coleman J, Zheng H, Simanjuntak M, Goder J, Rothman J, Espinosa J, Pincet F, López-Montero I. Molecular Flexibility and Electrostatic Interactions Drive the Nanoscale Structure of Coiled-Coil GM130 Protein Condensates. PRX Life 2026, 4: 023021. DOI: 10.1103/lp87-svtc.Peer-Reviewed Original ResearchSynaptic transmission: Munc13 assembles onto PI(4,5)P2-rich domains into trimers that cooperate to capture vesicles
Li F, Radhakrishnan A, Gautam S, Diaz G, Sundaram R, Coleman J, Zheng H, Grushin K, Chavent M, Rothman J, Pincet F. Synaptic transmission: Munc13 assembles onto PI(4,5)P2-rich domains into trimers that cooperate to capture vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2523347123. PMID: 41671179, PMCID: PMC12912961, DOI: 10.1073/pnas.2523347123.Peer-Reviewed Original Research
2025
Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release
Bera M, Grushin K, Kalyana Sundaram R, Hinzen J, Chen J, Chatterjee A, Radhakrishnan A, Lee S, Padmanarayana M, Coleman J, Pincet F, Rothman J, Dittman J. Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release. Nature Communications 2025, 16: 7222. PMID: 40764329, PMCID: PMC12325603, DOI: 10.1038/s41467-025-62420-7.Peer-Reviewed Original ResearchHighly stable planar asymmetric suspended membranes for investigating protein dynamics and membrane fusion
Bera M, Kalyana Sundaram R, Coleman J, Chatterjee A, Thoduvayil S, Pincet F, Ramakrishnan S. Highly stable planar asymmetric suspended membranes for investigating protein dynamics and membrane fusion. Nature Protocols 2025, 20: 3582-3606. PMID: 40461798, DOI: 10.1038/s41596-025-01192-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBiomimetic membrane in a microfluidic chip for the electrical and optical monitoring of biological reactions
Mion D, Bunel L, Ramakrishnan S, Heo P, Pincet F. Biomimetic membrane in a microfluidic chip for the electrical and optical monitoring of biological reactions. Nature Protocols 2025, 20: 3477-3508. PMID: 40461799, DOI: 10.1038/s41596-025-01171-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLithium fine tunes lipid membranes through phospholipid binding
Bunel L, Adrien V, Coleman J, Heo P, Pincet F. Lithium fine tunes lipid membranes through phospholipid binding. Scientific Reports 2025, 15: 13366. PMID: 40246965, PMCID: PMC12006515, DOI: 10.1038/s41598-025-97828-0.Peer-Reviewed Original Research
2024
Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers
Li F, Coleman J, Redondo-Morata L, Kalyana Sundaram R, Stroeva E, Rothman J, Pincet F. Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers. Communications Biology 2024, 7: 1608. PMID: 39627539, PMCID: PMC11615320, DOI: 10.1038/s42003-024-07317-9.Peer-Reviewed Original ResearchPhotosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations (Adv. Funct. Mater. 34/2024)
Weerakkody J, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides T, Gunasekara R, Ramakrishnan S. Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations (Adv. Funct. Mater. 34/2024). Advanced Functional Materials 2024, 34 DOI: 10.1002/adfm.202470191.Peer-Reviewed Original ResearchDual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion
Caruel M, Pincet F. Dual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion. Biomolecules 2024, 14: 600. PMID: 38786007, PMCID: PMC11117985, DOI: 10.3390/biom14050600.Peer-Reviewed Original ResearchAuthor Correction: Kinetic study of membrane protein interactions: from three to two dimensions
Adrien V, Reffay M, Taulier N, Verchère A, Monlezun L, Picard M, Ducruix A, Broutin I, Pincet F, Urbach W. Author Correction: Kinetic study of membrane protein interactions: from three to two dimensions. Scientific Reports 2024, 14: 8222. PMID: 38589433, PMCID: PMC11001852, DOI: 10.1038/s41598-024-58201-9.Commentaries, Editorials and Letters