John Rose, PhD
Cards
About
Titles
Professor Emeritus of Pathology and Senior Research Scientist
Director, Molecular Virology ProgramBiography
Dr. Rose earned his Ph.D. at Stanford University in 1973 in the laboratory of Dr. Charles Yanofsky. His thesis research focused on regulation of the tryptophan operon of E. coli. He then did postdoctoral research at MIT in the laboratories of Drs. David Baltimore and Harvey Lodish, where he began work on eucaryotic RNA viruses. In 1978, Dr. Rose took a faculty position at the Salk Institute, where he continued work on RNA virus transcription, as well as structure, function, and transport of the vesicular stomatitis virus (VSV) glycoprotein. In 1986, he moved to become Professor of Pathology and Cell Biology at Yale University School of Medicine. In 1994, his laboratory developed a system for recovering non-segmented, negative-strand RNA viruses from DNA plasmids. His work at Yale during the past fifteen years has focused largely on new approaches to vaccine development using vectors based on recombinant VSV and other viral replicons. This work has led to development of robust vaccine platforms that can protect animals against numerous viral and bacterial pathogens, typically after a single dose. A VSV-based HIV vaccine advanced from the Rose laboratory has recently completed a successful Phase I clinical trial.
Appointments
Pathology
EmeritusPrimaryPathology
Senior Research ScientistSecondary
Other Departments & Organizations
Education & Training
- Fellow
- Massachusetts Institute of Technology (1978)
- PhD
- Stanford University (1973)
- BS
- Brandeis University (1969)
Research
Academic Achievements and Community Involvement
Links & Media
News
- April 29, 2020Source: YaleNews
Researchers at Yale Pursuing COVID-19 Vaccine Based on Powerful Yale Platform
- April 17, 2020
Laying the groundwork
- December 01, 2008
Grants and contracts awarded to Yale School of Medicine
- April 15, 2006
The virus behind the cancer