Faye Rogers, PhD

Professor of Therapeutic Radiology

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Appointments

Therapeutic Radiology

Primary

Additional Titles

Associate Cancer Center Director, YCC Collaborative Excellence

Vice Chair for Collaborative Excellence, Therapeutic Radiology

Associate Director, Yale MD-PhD Program

Director, Yale BioMed Amgen Scholars Program

Contact Info

faye.rogers@yale.edu

203.737.3658

Therapeutic Radiology

PO Box 208040

New Haven, CT 06520-8040

United States

About

Titles

Professor of Therapeutic Radiology

Associate Cancer Center Director, YCC Collaborative Excellence; Vice Chair for Collaborative Excellence, Therapeutic Radiology; Associate Director, Yale MD-PhD Program; Director, Yale BioMed Amgen Scholars Program

Appointments

Therapeutic Radiology
Professor
Primary
Therapeutic Radiology

BioMed Amgen Scholars Program
DNA Damage and Genome Integrity
MD-PhD Program
Molecular Medicine, Pharmacology, and Physiology
Program in Translational Biomedicine (PTB)
Radiobiology
Therapeutic Radiology
Yale Cancer Center
Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Yale Ventures
YCC Collaborative Excellence
YSM Office of Collaborative Excellence

Education & Training

PhD: University of Maryland at Baltimore (1998)

Research

Overview

Medical Research Interests

Apoptosis; Biochemistry; Breast Neoplasms; DNA Repair; Drug Design; Genomic Instability; Nucleic Acids; Radiation Oncology

ORCID
0000-0002-1454-9892

Research at a Glance

Yale Co-Authors

Frequent collaborators of Faye Rogers's published research.

Adam Krysztofiak, PhD
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View 6 Common Publications
Peter M. Glazer, MD, PhD
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View 5 Common Publications
Daniel Andrés Colón Ríos
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View 4 Common Publications
Yanfeng Liu
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View 3 Common Publications
Jonathan Dow
View 2 Common Publications
Leonard Milstone, MD
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View 2 Common Publications

Publications

2025

PARP inhibitor resistance in IDH1-mutant cancers due to loss of end protection factors, 53BP1 and REV7
Colón-Ríos D, Dow J, Krysztofiak A, Liu Y, Rogers F, Glazer P. PARP inhibitor resistance in IDH1-mutant cancers due to loss of end protection factors, 53BP1 and REV7. NAR Cancer 2025, 7: zcaf047. PMID: 41357766, PMCID: PMC12675010, DOI: 10.1093/narcan/zcaf047.
Peer-Reviewed Original Research
This study investigates how IDH1-mutant cancers develop resistance to PARP inhibitors through loss of end protection factors, 53BP1 and REV7, and shows that the drug cediranib can overcome this resistance, highlighting potential therapeutic strategies for improving cancer treatment outcomes.
Full Summary
Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers
Minnah A, Tubéns N, Krysztofiak A, Liu Y, Glazer P, Rogers F. Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers. Molecular Therapy - Nucleic Acids 2025, 36: 102720. PMID: 41127334, PMCID: PMC12538099, DOI: 10.1016/j.omtn.2025.102720.
Peer-Reviewed Original Research

2024

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition
Rackear M, Quijano E, Ianniello Z, Colón-Ríos D, Krysztofiak A, Abdullah R, Liu Y, Rogers F, Ludwig D, Dwivedi R, Bleichert F, Glazer P. Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition. Oncotarget 2024, 15: 699-713. PMID: 39352803, PMCID: PMC11444335, DOI: 10.18632/oncotarget.28651.
Peer-Reviewed Original Research
MeSH Keywords

2022

The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus
Jimenez-Sainz J, Krysztofiak A, Garbarino J, Rogers F, Jensen RB. The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus. Frontiers In Genetics 2022, 13: 884210. PMID: 35711920, PMCID: PMC9197106, DOI: 10.3389/fgene.2022.884210.
Peer-Reviewed Original Research

2021

Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair
Dow J, Krysztofiak A, Liu Y, Colon-Rios DA, Rogers FA, Glazer PM. Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair. Molecular Cancer Research 2021, 19: 2057-2067. PMID: 34535560, PMCID: PMC8642278, DOI: 10.1158/1541-7786.mcr-21-0456.
Peer-Reviewed Original Research
MeSH Keywords
Direct targeting of amplified gene loci for proapoptotic anticancer therapy
Kaushik Tiwari M, Colon-Rios DA, Tumu HCR, Liu Y, Quijano E, Krysztofiak A, Chan C, Song E, Braddock DT, Suh HW, Saltzman WM, Rogers FA. Direct targeting of amplified gene loci for proapoptotic anticancer therapy. Nature Biotechnology 2021, 40: 325-334. PMID: 34711990, PMCID: PMC8930417, DOI: 10.1038/s41587-021-01057-5.
Peer-Reviewed Original Research
MeSH Keywords

2020

A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma
Adaku N, Park HB, Spakowicz DJ, Tiwari MK, Strobel SA, Crawford JM, Rogers FA. A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma. Journal Of Natural Products 2020, 83: 1899-1908. PMID: 32407116, DOI: 10.1021/acs.jnatprod.0c00012.
Peer-Reviewed Original Research
MeSH Keywords

2016

2014

Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases
Rogers FA, Lloyd JA, Tiwari MK. Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases. Artificial DNA PNA & XNA 2014, 5: e27792. PMID: 25483840, PMCID: PMC4014521, DOI: 10.4161/adna.27792.
Peer-Reviewed Original Research
MeSH Keywords

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Academic Achievements & Community Involvement

Honors

honor
Leadership in Diversity, Equity & Inclusion Award
03/24/2022Yale School of Medicine AwardYale Cancer Center
Details
honor
Translational Science Research Prize
03/24/2022Yale School of Medicine AwardYale Cancer Center
Details

News & Links

Media

Cellular Damage, Repair & Apoptosis - The Rogers Lab at Yale School of Medicine
A video about Dr. Rogers' research into cellular response to DNA damage in cancer.
Watch the video

News

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Related Links
- Selected PubMed Article Listing

Get In Touch

Contacts

faye.rogers@yale.edu

Academic Office Number

203.737.3658

Office Fax Number

203.785.6309

Mailing Address

Therapeutic Radiology

PO Box 208040

New Haven, CT 06520-8040

United States

Locations

Hunter Building
Academic Office
15 York Street, Ste 213B
New Haven, CT 06510
Appointments
203.737.3658
Fax
203.785.6309
Get Directions

Events

Feb 202716Tuesday

Yale Only
12:00 PM1:00 PM
Brian Capell, MD, PhD
PTB Translational Science Seminar Series
Brian Capell, MD, PhD (Penn University) - Title TBA
Hope Memorial Building
ZOOM LINK PASSWORD AVAILABLE UPON REQUEST (TIANA.SMITH@YALE.EDU)
https://yale.zoom.us/j/92398341165?pwd=ASSfI5cnQRemFh7G12OO1143HmpDrg.1
Add event to Calendar

Appointments

Additional Titles

Contact Info

Titles

Appointments

Therapeutic Radiology

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

Research at a Glance

Yale Co-Authors

Adam Krysztofiak, PhD

Peter M. Glazer, MD, PhD

Daniel Andrés Colón Ríos

Yanfeng Liu

Jonathan Dow

Leonard Milstone, MD

Publications

2025

2024

2022

2021

2020

2016

2014

Honors

Leadership in Diversity, Equity & Inclusion Award

Translational Science Research Prize

Media

News

Biomedical Summer Undergraduate Research Fellowship Symposium 2026

ACS Post-baccalaureate End-of-Year Celebration

Local High School Students Explore Cancer Biology at Yale

Biomedical Summer Undergraduate Research Fellowship Symposium 2025

Related Links

Contacts

Locations

Hunter Building

Events

PTB Translational Science Seminar Series