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Daryl Klein, MD, PhD

Associate Professor of Pharmacology
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About

Titles

Associate Professor of Pharmacology

Appointments

Education & Training

Research Fellow
Boston Children's Hospital (2016)
Postdoctoral Fellow
Harvard Medical School (2016)
MD
University of Pennsylvania, Medicine (2009)
PhD
University of Pennsylvania, Biochemistry and Biophysics (2008)
BA
University of Pennsylvania, Biology (1999)

Research

Overview

Dr. Klein is a trained physician-scientist committed to studying the molecular mechanisms of cancer, and ways to control pathways that lead to metastases. Both personally and as a medical professional, he has witnessed the devastation that cancer causes and its toll on families. This drives him everyday to find new and different ways to approach treatment strategies. Over the past two decades, Dr. Klein's basic science research has spanned multiple aspects of information transfer across biological membranes. Perception of environmental information across this barrier is essential for proper development and health - allowing each cell to know its "time" and "place" in a tissue. This circuitry can go awry in cancer, usurping the typical development logic-gates for adventitious growth. Dr. Klein's independent research focus is to decipher the underlying logic of signal integration across membranes to better understand how disease states take advantage of these signaling "codes." These codes are written in the three dimensional structures, kinetics and regulation of receptor activation. Ultimately, with physical and mathematical models of this signaling logic, Dr. Klein hopes to design synthetic circuitry to override the disease program, driving cells away from metastatic potential and enhancing the body's own targeted immune response. His goal is to bring together ideas from disparate fields including signaling, virology, biophysics, and high throughput screening - to realize the potential of "tuning" receptor activity to control metastatic disease.

Medical Subject Headings (MeSH)

Medical Oncology; Pharmacology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Daryl Klein's published research.

Publications

2023

2022

2016

2009

2001

1998

Get In Touch

Contacts

Academic Office Number
Lab Number

Administrative Support

Locations

  • Klein Lab

    Lab

    West Campus Advanced Biosciences Center

    840 West Campus Drive, Rm 367

    West Haven, CT 06516

Events