Carolina Lucas, PhD
Assistant ProfessorDownloadHi-Res Photo
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Immunobiology
Primary
Additional Titles
Affiliated Faculty, Center for Infection and Immunity
Affiliated Faculty, Yale Institute for Global Health
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Appointments
Immunobiology
Primary
Additional Titles
Affiliated Faculty, Center for Infection and Immunity
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Appointments
Immunobiology
Primary
Additional Titles
Affiliated Faculty, Center for Infection and Immunity
Affiliated Faculty, Yale Institute for Global Health
Contact Info
About
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Titles
Assistant Professor
Affiliated Faculty, Center for Infection and Immunity; Affiliated Faculty, Yale Institute for Global Health
Biography
Carolina Lucas PhD is an Assistant Professor of Immunobiology and a member of the Center for Infection and Immunity at Yale University. She received her Ph.D. from UFRJ/ETH in Brazil and Switzerland and completed her postdoctoral training at Yale in Dr. Akiko Iwasaki Lab studying emerging virus pathogenesis, including Zika virus, CHIKV and SARS-CoV-2. The Lucas Lab is dedicated to understanding basic immune mechanisms necessary for controlling emerging viral infections and to lay the groundwork for new therapeutic approaches and vaccination strategies. Specifically, the lab explores immune responses following vaccination or infection that contribute to both resistance and disease tolerance mechanisms across different age groups.
Last Updated on May 17, 2025.
Appointments
Immunobiology
Assistant ProfessorPrimary
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Research
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Overview
Medical Research Interests
Adaptive Immunity; Aging; DNA Virus Infections; Immunity; Immunity, Innate; Immunity, Mucosal; Infectious Disease Medicine; RNA Virus Infections; Virology
Public Health Interests
Aging; Emerging Infectious Diseases; Global Health
ORCID
0000-0003-4590-2756
Research at a Glance
Yale Co-Authors
Frequent collaborators of Carolina Lucas, PhD's published research.
Publications Timeline
A big-picture view of Carolina Lucas, PhD's research output by year.
Research Interests
Research topics Carolina Lucas, PhD is interested in exploring.
Akiko Iwasaki, PhD
Valter Silva Monteiro
Albert Icksang Ko, MD
Nathan Grubaugh, PhD
Chantal Vogels, PhD
Inci Yildirim, MD, PhD, MSc
29Publications
2,797Citations
Adaptive Immunity
Aging
Immunity
Immunity, Innate
Publications
2026
Neutralising antibody responses to MPXV clades Ia, Ib, and IIb after infection or vaccination: a multicountry observational study
Crandell J, Fantin R, de Araújo L, Lawres L, Pischel L, Monteiro V, Conde L, Kottkamp A, Samanovic M, Cordeiro R, Póvoas D, Melo M, Castineiras T, Vale A, Yildirim I, Mulligan M, de Almeida L, Coelho C, Lucas C. Neutralising antibody responses to MPXV clades Ia, Ib, and IIb after infection or vaccination: a multicountry observational study. The Lancet Infectious Diseases 2026 PMID: 42314719, DOI: 10.1016/s1473-3099(26)00173-8.Peer-Reviewed Original ResearchCitationsAltmetric
2025
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity
Fang Z, Monteiro V, Oh C, Janabi K, Romero L, Ahsan N, Yang L, Peng L, DiMaio D, Lucas C, Chen S. A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity. Nature Biomedical Engineering 2025, 10: 501-516. PMID: 40855125, DOI: 10.1038/s41551-025-01478-6.Peer-Reviewed Original ResearchCitationsAltmetricImpact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID
Grady C, Bhattacharjee B, Silva J, Jaycox J, Lee L, Silva Monteiro V, Sawano M, Massey D, Caraballo C, Gehlhausen J, Tabachnikova A, Mao T, Lucas C, Peña-Hernandez M, Xu L, Tzeng T, Takahashi T, Herrin J, Güthe D, Akrami A, Assaf G, Davis H, Harris K, McCorkell L, Schulz W, Griffin D, Wei H, Ring A, Guan L, Dela Cruz C, Krumholz H, Iwasaki A. Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID. Communications Medicine 2025, 5: 163. PMID: 40346201, PMCID: PMC12064684, DOI: 10.1038/s43856-025-00829-3.Peer-Reviewed Original ResearchCitationsAltmetricThe impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study
Crandell J, Monteiro V, Pischel L, Fang Z, Conde L, Zhong Y, Lawres L, de Asis G, Maciel G, Zaleski A, Lira G, Higa L, Breban M, Vogels C, Caria J, Pinto A, Almeida V, Maltez F, Cordeiro R, Póvoas D, Grubaugh N, Aoun-Barakat L, Grifoni A, Sette A, Castineiras T, Chen S, Yildirim I, Vale A, Omer S, Lucas C. The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study. The Lancet Microbe 2025, 6: 101098. PMID: 40311645, DOI: 10.1016/j.lanmic.2025.101098.Peer-Reviewed Original ResearchCitationsAltmetric
2024
The Benjamin Button effect on stem cells: Reversing the clock on aging immunity.
Conde L, Lucas C. The Benjamin Button effect on stem cells: Reversing the clock on aging immunity. Science Immunology 2024, 9: eadq0013. PMID: 38701191, DOI: 10.1126/sciimmunol.adq0013.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchCitationsAltmetricCytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis. Science Immunology 2023, 8: eadh3455-eadh3455. PMID: 37146127, PMCID: PMC10468758, DOI: 10.1126/sciimmunol.adh3455.Peer-Reviewed Original ResearchCitationsAltmetricEnhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Moriyama M, Lucas C, Monteiro V, Initiative Y, Iwasaki A, Chen N, Breban M, Hahn A, Pham K, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Vogels C, Grubaugh N. Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2221652120. PMID: 37036977, PMCID: PMC10120007, DOI: 10.1073/pnas.2221652120.Peer-Reviewed Original ResearchCitationsAltmetricNonsystematic Reporting Biases of the SARS-CoV-2 Variant Mu Could Impact Our Understanding of the Epidemiological Dynamics of Emerging Variants
Petrone M, Lucas C, Menasche B, Breban M, Yildirim I, Campbell M, Omer S, Holmes E, Ko A, Grubaugh N, Iwasaki A, Wilen C, Vogels C, Fauver J. Nonsystematic Reporting Biases of the SARS-CoV-2 Variant Mu Could Impact Our Understanding of the Epidemiological Dynamics of Emerging Variants. Genome Biology And Evolution 2023, 15: evad052. PMID: 36974986, PMCID: PMC10113931, DOI: 10.1093/gbe/evad052.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsSARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity
Jaycox J, Lucas C, Yildirim I, Dai Y, Wang E, Monteiro V, Lord S, Carlin J, Kita M, Buckner J, Ma S, Campbell M, Ko A, Omer S, Lucas C, Speake C, Iwasaki A, Ring A. SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity. Nature Communications 2023, 14: 1299. PMID: 36894554, PMCID: PMC9996559, DOI: 10.1038/s41467-023-36686-8.Peer-Reviewed Original ResearchCitationsAltmetric
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