2024
Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Ke S, Dang F, Wang L, Chen J, Naik M, Li W, Thavamani A, Kim N, Naik N, Sui H, Tang W, Qiu C, Koikawa K, Batalini F, Stern Gatof E, Isaza D, Patel J, Wang X, Clohessy J, Heng Y, Lahav G, Liu Y, Gray N, Zhou X, Wei W, Wulf G, Lu K. Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry. Nature Communications 2024, 15: 3220. PMID: 38622115, PMCID: PMC11018817, DOI: 10.1038/s41467-024-47427-w.Peer-Reviewed Original ResearchConceptsCyclin-dependent protein kinasesCell cycle entryMitotic proteinsProtein stabilityActivator of anaphase-promoting complexPermanent cell cycle exitAnaphase-promoting complexE3 ligase activityCo-activator Cdh1Cell cycle exitLigase activityPositive feedback loopProlyl isomerizationProteomic screenProtein kinaseCycle entryProtein turnoverPin1Oncoprotein degradationCo-activationAPC/CCdh1Pin1 inhibitionTriple-negative breast cancerProteinPhosphorylation
2021
Cross-compartment signal propagation in the mitotic exit network
Zhou X, Li W, Liu Y, Amon A. Cross-compartment signal propagation in the mitotic exit network. ELife 2021, 10: e63645. PMID: 33481703, PMCID: PMC7822594, DOI: 10.7554/elife.63645.Peer-Reviewed Original Research
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