2019
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
Gao Q, Zhu H, Dong L, Shi W, Chen R, Song Z, Huang C, Li J, Dong X, Zhou Y, Liu Q, Ma L, Wang X, Zhou J, Liu Y, Boja E, Robles A, Ma W, Wang P, Li Y, Ding L, Wen B, Zhang B, Rodriguez H, Gao D, Zhou H, Fan J. Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma. Cell 2019, 179: 561-577.e22. PMID: 31585088, DOI: 10.1016/j.cell.2019.08.052.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsbeta CateninCarcinoma, HepatocellularCell ProliferationCohort StudiesFemaleFructose-Bisphosphate AldolaseGene Expression ProfilingGene Expression Regulation, NeoplasticHep G2 CellsHepatitis B virusHepatitis B, ChronicHumansLiver NeoplasmsMaleMiceMice, Inbred BALB CMiddle AgedProteogenomicsTumor MicroenvironmentConceptsHepatitis B virus (HBV)-related hepatocellular carcinomaHBV-related HCCMetabolic reprogrammingHepatocellular carcinomaProteogenomic characterizationHBV-related hepatocellular carcinomaCell proliferationAdjacent liver tissuesIntegrative proteogenomic analysisMicroenvironment dysregulationBenefit clinical practiceTumor thrombusPatient survivalPaired tumorPrognostic biomarkerMetabolic profileActivation statusClinical practiceGenetic profileCarcinomaLiver tissueTumorSignaling pathwayPromote glycolysisPatients
2018
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS
Sajic T, Liu Y, Arvaniti E, Surinova S, Williams EG, Schiess R, Hüttenhain R, Sethi A, Pan S, Brentnall TA, Chen R, Blattmann P, Friedrich B, Niméus E, Malander S, Omlin A, Gillessen S, Claassen M, Aebersold R. Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Cell Reports 2018, 23: 2819-2831.e5. PMID: 29847809, DOI: 10.1016/j.celrep.2018.04.114.Peer-Reviewed Original ResearchConceptsN-glycoproteinsAvailable proteomic dataSWATH mass spectrometryImmense clinical interestCancer-type specificProteomic changesProteomic dataN-glycositesProteomic workflowParticular carcinomaProtein compositionClinical stageMetastatic stageBlood samplesPatient plasmaSolid carcinomasEarly cancer detectionSWATH-MSTumor tissueSystemic responseCarcinomaProteinEarly detectionClinical interestCancer
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