2023
Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans
Kimbrel N, Ashley-Koch A, Qin X, Lindquist J, Garrett M, Dennis M, Hair L, Huffman J, Jacobson D, Madduri R, Trafton J, Coon H, Docherty A, Mullins N, Ruderfer D, Harvey P, McMahon B, Oslin D, Beckham J, Hauser E, Hauser M, Agarwal K, Ashley-Koch A, Aslan M, Beckham J, Begoli E, Bhattacharya T, Brown B, Calhoun P, Cheung K, Choudhury S, Cliff A, Cohn J, Crivelli S, Cuellar-Hengartner L, Deangelis H, Dennis M, Dhaubhadel S, Finley P, Ganguly K, Garvin M, Gelernter J, Hair L, Harvey P, Hauser E, Hauser M, Hengartner N, Jacobson D, Jones P, Kainer D, Kaplan A, Katz I, Kember R, Kimbrel N, Kirby A, Ko J, Kolade B, Lagergren J, Lane M, Levey D, Levin D, Lindquist J, Liu X, Madduri R, Manore C, Martins S, McCarthy J, McDevitt-Cashman M, McMahon B, Miller I, Morrow D, Oslin D, Pavicic-Venegas M, Pestian J, Pyarajan S, Qin X, Rajeevan N, Ramsey C, Ribeiro R, Rodriguez A, Romero J, Santel D, Schaefferkoetter N, Shi Y, Stein M, Sullivan K, Sun N, Tamang S, Townsend A, Trafton J, Walker A, Wang X, Wangia-Anderson V, Yang R, Yoon H, Yoo S, Zamora-Resendiz R, Zhao H, Docherty A, Mullins N, Coleman J, Shabalin A, Kang J, Murnyak B, Wendt F, Adams M, Campos A, DiBlasi E, Fullerton J, Kranzler H, Bakian A, Monson E, Rentería M, Andreassen O, Bulik C, Edenberg H, Kessler R, Mann J, Nurnberger J, Pistis G, Streit F, Ursano R, Awasthi S, Bergen A, Berrettini W, Bohus M, Brandt H, Chang X, Chen H, Chen W, Christensen E, Crawford S, Crow S, Duriez P, Edwards A, Fernández-Aranda F, Fichter M, Galfalvy H, Gallinger S, Gandal M, Gorwood P, Guo Y, Hafferty J, Hakonarson H, Halmi K, Hishimoto A, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan A, Kaye W, Keel P, Kennedy J, Kim M, Klump K, Levey D, Li D, Liao S, Lieb K, Lilenfeld L, Lori A, Magistretti P, Marshall C, Mitchell J, Myers R, Okazaki S, Otsuka I, Pinto D, Powers A, Ramoz N, Ripke S, Roepke S, Rozanov V, Scherer S, Schmahl C, Sokolowski M, Starnawska A, Strober M, Su M, Thornton L, Treasure J, Ware E, Watson H, Witt S, Woodside D, Yilmaz Z, Zillich L, Agerbo E, Børglum A, Breen G, Demontis D, Erlangsen A, Esko T, Gelernter J, Glatt S, Hougaard D, Hwu H, Kuo P, Lewis C, Li Q, Liu C, Martin N, McIntosh A, Medland S, Mors O, Nordentoft M, Nurnberger J, Olsen C, Porteous D, Smith D, Stahl E, Stein M, Wasserman D, Werge T, Whiteman D, Willour V, Coon H, Ruderfer D, Dedert E, Elbogen E, Fairbank J, Hurley R, Kilts J, Martindale S, Marx C, McDonald S, Moore S, Morey R, Naylor J, Rowland J, Shura R, Swinkels C, Tupler L, Van Voorhees E, Yoash-Gantz R, Gaziano J, Muralidhar S, Ramoni R, Chang K, O’Donnell C, Tsao P, Breeling J, Hauser E, Sun Y, Huang G, Casas J, Moser J, Whitbourne S, Brewer J, Conner T, Argyres D, Stephens B, Brophy M, Humphries D, Selva L, Do N, Shayan S, Cho K, Churby L, Wilson P, McArdle R, Dellitalia L, Mattocks K, Harley J, Whittle J, Jacono F, Wells J, Gutierrez S, Gibson G, Hammer K, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Mathew R, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Ivins D, Mastorides S, Moorman J, Gappy S, Klein J, Ratcliffe N, Florez H, Okusaga O, Murdoch M, Sriram P, Yeh S, Tandon N, Jhala D, Liangpunsakul S, Oursler K, Whooley M, Ahuja S, Constans J, Meyer P, Greco J, Rauchman M, Servatius R, Gaddy M, Wallbom A, Morgan T, Stapley T, Sherman S, Ross G, Strollo P, Boyko E, Meyer L, Gupta S, Huq M, Fayad J, Hung A, Lichy J, Hurley R, Robey B, Striker R. Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans. JAMA Psychiatry 2023, 80: 135-145. PMID: 36515925, PMCID: PMC9857322, DOI: 10.1001/jamapsychiatry.2022.3896.Peer-Reviewed Original ResearchConceptsMolecular genetic basisRisk lociSingle nucleotide variantsGWS lociGenetic basisGenomic risk lociRisk genesGenome-wide association studiesSignificant enrichmentGene-based analysisGenetic risk lociCandidate risk genesCyclic adenosine monophosphate (cAMP) signalingIdentification of novelPolygenic risk score analysisGene clusterFocal adhesionsGenetic substructureUbiquitination processChromosome 2Enrichment analysisAssociation studiesAxon guidanceAfrican ancestryNCAM1-TTC12
2019
Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci
Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB, Program D, Program M. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biological Psychiatry 2019, 86: 365-376. PMID: 31151762, PMCID: PMC6919570, DOI: 10.1016/j.biopsych.2019.03.984.Peer-Reviewed Original ResearchConceptsAdditional genome-wide significant lociRisk lociWide association study (GWAS) analysisAssociation studiesGenome-wide significant lociGenome-wide association studiesGenetic correlationsWide association studyNovel risk lociAlcohol-related traitsStrong statistical supportSmoking-related traitsAdditional genomesSignificant lociPancreatic delta cellsChromosome 4Chromosome 11Protein productsChromosome 8Quantitative phenotypesMillion Veteran ProgramVeterans Affairs Million Veteran ProgramLociCell typesChromosome 17
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