2025
Differential results of genetic risk scoring for multiple sclerosis in European and African American populations
Rivier C, Xu L, Clocchiatti-Tuozzo S, Zhao H, Ohno-Machado L, Hafler D, Falcone G, Longbrake E. Differential results of genetic risk scoring for multiple sclerosis in European and African American populations. Multiple Sclerosis Journal 2025, 31: 1304-1313. PMID: 40991630, DOI: 10.1177/13524585251377607.Peer-Reviewed Original ResearchConceptsGenetic risk scoreInternational ClassificationSystematized Nomenclature of MedicineAfrican ancestryRisk scoreCross-sectional studyHigh-risk individualsMultiple sclerosisSystematized NomenclatureAfrican American populationAfrican ancestry groupMS prevalenceAncestry groupsMS riskNomenclature of MedicineAmerican populationParticipantsAfrican participantsAncestryEuropean populationsClinical trialsDifferentiation resultsScoresIndividualsPopulationPolygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program
Huo S, Rivier C, Clocchiatti‐Tuozzo S, Renedo D, Petersen N, de Havenon A, Meeker D, Zhao H, Ohno‐Machado L, Sheth K, Falcone G. Polygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program. Annals Of Neurology 2025 PMID: 40827941, DOI: 10.1002/ana.78009.Peer-Reviewed Original ResearchUs Research ProgramUncontrolled hypertensionSystolic BPGenetic riskSusceptibility to hypertensionRates of uncontrolled hypertensionPolygenic risk scoresAssociated with higher systolic BPOdds of uncontrolled hypertensionCox proportional hazards regressionUnited Kingdom BiobankGenetic association studiesHigh-risk individualsHigher systolic BPProportional hazards regressionBlood pressure treatmentIncident strokeStroke hazardBlood pressureHigher RatesSystolic blood pressureHypertensive adultsDiagnosed hypertensionBP medicationsHazards regression
2003
A nationwide adaptive prediction tool for coronary heart disease prevention.
Holt T, Ohno-Machado L. A nationwide adaptive prediction tool for coronary heart disease prevention. British Journal Of General Practice 2003, 53: 866-70. PMID: 14702907, PMCID: PMC1314730.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdditional cardiovascular risk factorsCardiovascular risk factor dataCoronary heart disease preventionCardiovascular risk profileCardiovascular risk factorsHeart disease preventionRisk factor dataCardiovascular disease developmentHigh-risk individualsPrimary care deliveryPrimary prevention interventionsRisk modificationPrimary careRisk factorsPrevention interventionsDisease preventionCare deliveryRisk profileRisk patternsFeedback of dataDisease developmentInterventionPopulation levelFactor dataLong term
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