Emily Johns
About
Research
Publications
2026
Characterizing amyloid and tau positron emission tomography‐based stages across the clinical continuum
Cody K, Sokołowski A, Johns E, Guerra L, Winer J, Young C, Younes K, Dumitrescu L, Archer D, Durant A, Sathe A, Koran M, Mez J, Saykin A, Toga A, Cuccaro M, Tosun D, Insel P, Johnson S, Harrison T, Hohman T, Mormino E. Characterizing amyloid and tau positron emission tomography‐based stages across the clinical continuum. Alzheimer's & Dementia 2026, 22: e71017. PMID: 41505234, PMCID: PMC12782155, DOI: 10.1002/alz.71017.Peer-Reviewed Original Research
2025
Intervention on Modifiable Lifestyle and Physiological Factors via Variational Autoencoder Reveals Changes in Functional Connectivity-Mediated Risk for Alzheimer's Disease.
Orlichenko A, Ding S, Johns E, Gu Z, Tian X, Li X, Zhao Y. Intervention on Modifiable Lifestyle and Physiological Factors via Variational Autoencoder Reveals Changes in Functional Connectivity-Mediated Risk for Alzheimer's Disease. MedRxiv 2025 PMID: 41001445, DOI: 10.1101/2025.09.16.25335925.Peer-Reviewed Original ResearchAmyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort
Younes K, Johns E, Young C, Kennedy G, Mukherjee S, Vossler H, Winer J, Cody K, Henderson V, Poston K, Betthauser T, Bevis B, Brooks W, Burns J, Coombes S, DeCarli C, DiFilippo F, Duara R, Fan A, Gibbons L, Golde T, Johnson S, Lepping R, Leverenz J, McDougall S, Rogalski E, Sanders E, Pasaye J, Sridhar J, Saykin A, Sridharan A, Swerdlow R, Trittschuh E, Vaillancourt D, Vidoni E, Wang W, Mez J, Hohman T, Tosun D, Biber S, Kukull W, Crane P, Mormino E. Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort. Alzheimer's & Dementia 2025, 21: e70075. PMID: 40145384, PMCID: PMC11947745, DOI: 10.1002/alz.70075.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentGlobal cognitionAmyloid positron emission tomographyPositron emission tomographyCognitive impairmentExecutive functionAmyloid burdenAssociated with lower initial levelsAssociated with poorer memoryNational Alzheimer's Coordinating Center participantsAlzheimer's diseaseEmission tomographyCognitively unimpaired individualsLow initial levelsPoor memoryInitial memoryUnimpaired groupCognitive trajectoriesCognition to mild cognitive impairmentCognitionCognitive declineImpairment groupUnimpaired individualsProportion of declineAmyloid levels
2024
MRI-free processing of tau PET images for early detection
Carlson M, Smith V, Johns E, Young C, Vossler H, Ward T, Harrison T, Tosun D, Hohman T, Landau S, Mormino E. MRI-free processing of tau PET images for early detection. Imaging Neuroscience 2024, 2: imag-2-00369. PMID: 40800382, PMCID: PMC12315776, DOI: 10.1162/imag_a_00369.Peer-Reviewed Original ResearchChildhood sexual abuse and lifetime depressive symptoms: the importance of type and timing of childhood emotional maltreatment
Hutson L, Dan R, Brown A, Esfand S, Ruberto V, Johns E, Null K, Ohashi K, Khan A, Du F, Teicher M, Pizzagalli D. Childhood sexual abuse and lifetime depressive symptoms: the importance of type and timing of childhood emotional maltreatment. Psychological Medicine 2024, 54: 4385-4395. PMID: 39618324, PMCID: PMC11650171, DOI: 10.1017/s003329172400268x.Peer-Reviewed Original ResearchConceptsChildhood sexual abuseMajor depressive disorderCurrent depressive symptomsDepressive symptomsEmotional maltreatmentMaltreatment subtypesDevelopment of Major Depressive DisorderEffects of emotional maltreatmentSexual abuseChildhood emotional maltreatmentParental verbal abuseSelf-report measuresSeverity of maltreatmentBeck Depression InventoryDepressive disorderAbuse ChronologyDepressive symptomatologyMaltreatment historyBDI-IIDepression InventorySalient risk factorsLate adolescenceIntervention effortsMaltreatmentAbuseBrain encoding during perceived control as a prospective predictor of improvement in quality of life
Dan R, Brown A, Hutson L, Belleau E, Esfand S, Ruberto V, Johns E, Null K, Du F, Pizzagalli D. Brain encoding during perceived control as a prospective predictor of improvement in quality of life. Social Cognitive And Affective Neuroscience 2024, 19: nsae075. PMID: 39420578, PMCID: PMC11556337, DOI: 10.1093/scan/nsae075.Peer-Reviewed Original ResearchConceptsProspective predictorsBrain activityPerceived ControlPrefrontal cortexBrain predictorsPredictors of improvementPerceived stressFunctional magnetic resonance imaging scannerDorsolateral prefrontal cortexStress-related disordersNeural underpinningsMid-cingulatePosterior cingulateQuality of lifeQuality of life 6 monthsControl taskActivity to controlMagnetic resonance imaging scannerMental healthLife EnjoymentCortexExploratory analysisLack of controlMotor cortexBrainFlorbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation
Johns E, Vossler H, Young C, Carlson M, Winer J, Younes K, Park J, Rathmann‐Bloch J, Smith V, Harrison T, Landau S, Henderson V, Wagner A, Sha S, Zeineh M, Zaharchuk G, Poston K, Davidzon G, Mormino E. Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation. Alzheimer's & Dementia 2024, 20: 5299-5310. PMID: 38962867, PMCID: PMC11350032, DOI: 10.1002/alz.13893.Peer-Reviewed Original ResearchConceptsPositron emission tomographyImpact of acquisition timeReference regionPositron emission tomography scanFlorbetaben positron emission tomographyAmyloid-positive individualsScan acquisition timeAmyloid-positive participantsAcquisition timeCerebellar gray matterStandardized acquisition protocolClinical protocolsCognitive impairmentEmission tomographyPET imagingPost-injectionGray matterPET dataAcquisition protocolsT-testFlorbetabenLinear mixed modelsTemporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer‘s disease
Younes K, Smith V, Johns E, Carlson M, Winer J, He Z, Henderson V, Greicius M, Young C, Mormino E, Researchers A. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer‘s disease. Brain Behavior And Immunity 2024, 119: 807-817. PMID: 38710339, PMCID: PMC12188992, DOI: 10.1016/j.bbi.2024.05.002.Peer-Reviewed Original ResearchConceptsAlzheimer s diseasePsychiatric symptomsAlzheimer's Disease Neuroimaging InitiativeSocial cognitive measuresAmyloid-positive participantsRight-sided asymmetryAssociated with worse behaviorsExecutive functionCognitive profileCognitive measuresNeuropsychiatric InventoryBehavioral symptomsLaterality indexTemporal lobeComposite scorePET asymmetryLanguage patternsTau progressionExtremity groupBad languageAlzheimer's diseaseTau burdenTauS diseaseLanguage
2023
Impact of florbetaben acquisition timing on continuous and dichotomous measures of amyloid burden: implications for real‐world amyloid PET interpretation
Johns E, Young C, Vossler H, Younes K, Trelle A, Poston K, Davidzon G, Mormino E. Impact of florbetaben acquisition timing on continuous and dichotomous measures of amyloid burden: implications for real‐world amyloid PET interpretation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080405.Peer-Reviewed Original ResearchImpact of florbetaben acquisition timing on continuous and dichotomous measures of amyloid burden: implications for real‐world amyloid PET interpretation
Johns E, Young C, Vossler H, Younes K, Trelle A, Poston K, Davidzon G, Mormino E. Impact of florbetaben acquisition timing on continuous and dichotomous measures of amyloid burden: implications for real‐world amyloid PET interpretation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.082004.Peer-Reviewed Original Research
Get In Touch
Contacts
Email