2007
Sinomenine suppresses TNF-α-induced VCAM-1 expression in human umbilical vein endothelial cells
Huang J, Lin Z, Luo M, Lu C, Kim M, Yu B, Gu J. Sinomenine suppresses TNF-α-induced VCAM-1 expression in human umbilical vein endothelial cells. Journal Of Ethnopharmacology 2007, 114: 180-185. PMID: 17869461, DOI: 10.1016/j.jep.2007.07.036.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalCell SeparationCell SurvivalCells, CulturedEndothelial CellsEndothelium, VascularFactor VIIIFlow CytometryHumansImmunohistochemistryIndicators and ReagentsMorphinansNF-kappa BReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStimulation, ChemicalTumor Necrosis Factor-alphaUmbilical VeinsVascular Cell Adhesion Molecule-1ConceptsVCAM-1 expressionHuman umbilical vein endothelial cellsTNF-alpha-induced VCAM-1 expressionTNF-alphaVCAM-1 mRNA expressionVCAM-1MRNA expressionMethods of immunotherapyExpression of VCAM-1Rheumatic heart diseaseTNF-alpha-induced human umbilical vein endothelial cellsEffects in vitroUmbilical vein endothelial cellsInhibitory effect in vitroVCAM-1 mRNASymptoms of rheumatismRheumatic carditisVein endothelial cellsReal-time quantitative PCRSinomenium acutum RehdFlow cytometryHeart diseaseExperimental groupEndothelial cellsEvaluated in vitro
1991
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
Sofuoglu M, Portoghese P, Takemori A. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 676-680. PMID: 1851833, DOI: 10.1016/s0022-3565(25)24699-7.Peer-Reviewed Original ResearchConceptsAntinociceptive ED50Antinociceptive actionMorphine sulfateAntinociceptive assaysDelta-opioid receptor agonistDelta opioid receptor subtypesDelta-opioid subtypesOpioid receptor agonistsOpioid receptor subtypesSingle large doseDelta-opioid agonistsPretreatment of animalsOpioid subtypesOpioid agonistsSpinal sitesDifferential antagonismReceptor agonistReceptor subtypesAntinociceptive activityD-Ala2Large doseDSLETDPDPENaltrindoleAntagonist activity
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