2018
The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats
Costa G, Serra M, Pintori N, Casu M, Zanda M, Murtas D, De Luca M, Simola N, Fattore L. The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats. Neuropharmacology 2018, 144: 219-232. PMID: 30366005, DOI: 10.1016/j.neuropharm.2018.10.031.Peer-Reviewed Original ResearchConceptsEffects of methoxetamineElevated plus mazePersistent behavioral abnormalitiesBehavioral effectsPlus mazeLocomotor activityBehavioral abnormalitiesDensity of dopamine transportersLocomotor activity of ratsImpaired non-spatial memoryNovel object recognition testEmission of ultrasonic vocalizationsMedial prefrontal cortexMarble burying testVentral tegmental areaPersistent behavioral effectsNon-spatial memoryNovel object recognitionObject recognition testActivity of ratsNeurotoxic effectsSubstantia nigra pars compactaSerotonergic damageNucleus accumbensBurying testDivergent Stereoselectivity in Phosphothreonine (pThr)-Catalyzed Reductive Aminations of 3‑Amidocyclohexanones
Shugrue C, Featherston AL, Lackner RM, Lin A, Miller SJ. Divergent Stereoselectivity in Phosphothreonine (pThr)-Catalyzed Reductive Aminations of 3‑Amidocyclohexanones. The Journal Of Organic Chemistry 2018, 83: 4491-4504. PMID: 29547285, PMCID: PMC5963540, DOI: 10.1021/acs.joc.8b00207.Peer-Reviewed Original ResearchConceptsReductive aminationNumerous reactive sitesPeptide catalystsParallel kinetic resolutionDFT calculationsNMR studiesReactive sitesDivergent selectivitySecondary interactionsNatural productsKinetic resolutionCatalystAminationDivergent stereoselectivitiesCatalyzed Reductive AminationPeptide sequencesSelectivityComplex substratesSubstrateDiastereoselectivityStereoselectivityProductsReactivityPhosphopeptidesPhosphothreonine
2017
Methoxetamine affects brain processing involved in emotional response in rats
Zanda M, Fadda P, Antinori S, Di Chio M, Fratta W, Chiamulera C, Fattore L. Methoxetamine affects brain processing involved in emotional response in rats. British Journal Of Pharmacology 2017, 174: 3333-3345. PMID: 28718892, PMCID: PMC5595753, DOI: 10.1111/bph.13952.Peer-Reviewed Original ResearchConceptsBehaviorally active dosesDecreased social interaction timeMotor activityMedial prefrontal cortexObsessive-compulsive traitsReduced immobility timeSocial interaction timeSelf-grooming behaviorIncreased phosphorylation of ribosomal protein S6Antidepressant effectsImmobility timePrefrontal cortexBehavioral effectsIncreased sociabilitySpatial anxietyAcute administrationBrain processesHigh dosesIncreased swimming activityEmotional responsesDissociative effectsEmotional statesIntermediate dosePsychoactive substancesMethoxetamine
2016
A 54‐year‐old woman with arthritis and discoloration of the hands, ears, and sclerae
Yin ES, Knispel JD, McNiff JM, Leventhal JS. A 54‐year‐old woman with arthritis and discoloration of the hands, ears, and sclerae. International Journal Of Dermatology 2016, 56: 715-717. PMID: 27651033, DOI: 10.1111/ijd.13415.Peer-Reviewed Original ResearchSolution Structures and Molecular Associations of a Peptide-Based Catalyst for the Stereoselective Baeyer–Villiger Oxidation
Abascal NC, Miller SJ. Solution Structures and Molecular Associations of a Peptide-Based Catalyst for the Stereoselective Baeyer–Villiger Oxidation. Organic Letters 2016, 18: 4646-4649. PMID: 27588823, PMCID: PMC5130343, DOI: 10.1021/acs.orglett.6b02282.Peer-Reviewed Original ResearchMeSH KeywordsCatalysisCyclohexanonesMolecular StructureOxidation-ReductionPeptidesSolutionsStereoisomerismConceptsBaeyer-Villiger oxidationPeptide-based catalystsStereoselective Baeyer–Villiger oxidationsCatalytic reactionStereoselective catalystsEffect of additivesSolution conformationCatalystMolecular associationSubstrate-specific interactionsUnique structureSolution structureOxidationStructural analysisAdvantageous featuresSelectivityExperimental observationsPeptidesConformationStructureAdditivesReactionMethoxetamine, a novel psychoactive substance with serious adverse pharmacological effects
Zanda M, Fadda P, Chiamulera C, Fratta W, Fattore L. Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects. Behavioural Pharmacology 2016, 27: 489-496. PMID: 27128862, DOI: 10.1097/fbp.0000000000000241.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclohexanonesCyclohexylaminesDopamineHumansIllicit DrugsSubstance-Related DisordersTime FactorsConceptsEffects of methoxetamineN-methyl-d-aspartate receptor antagonistic propertiesPsychoactive substancesReceptor antagonist propertiesOccurrence of adverse effectsAdverse pharmacological effectsDopamine neurotransmissionMesolimbic pathwayAntidepressant activityPreclinical dataPreclinical findingsAntagonistic propertiesLong-term effectsPharmacological effectsStimulatory effectMethoxetamineAdverse effectsKetamineLegal highsResearch chemicalsToxicological effectsPhencyclidineDopamineNeurotransmissionIncreasing number
2011
Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease
Oh U, McCormick M, Datta D, Turner R, Bobb K, Monie D, Sliskovic D, Tanaka Y, Zhang J, Meshulam J, Jacobson S. Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease. Blood 2011, 117: 3363-3369. PMID: 21212284, PMCID: PMC3069676, DOI: 10.1182/blood-2010-10-306571.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsHAM/TSPNF-κB activationImmune activationHuman T-lymphotropic virus type IMyelopathy/tropical spastic paraparesisNuclear factor-kappa B (NF-κB) inhibitorChronic inflammatory disordersBlood mononuclear cellsLymphocyte activation markersTropical spastic paraparesisCentral nervous systemNF-κB pathwayNF-κB inhibitionNovel small molecule inhibitorVirus type ICanonical NF-κB activationViral protein expressionSpontaneous lymphoproliferationShort-term cultureActivation markersInflammatory disordersMononuclear cellsSpastic paraparesisNeurologic disease
2009
Chemical Dissection of an Essential Redox Switch in Yeast
Paulsen CE, Carroll KS. Chemical Dissection of an Essential Redox Switch in Yeast. Cell Chemical Biology 2009, 16: 217-225. PMID: 19230722, DOI: 10.1016/j.chembiol.2009.01.003.Peer-Reviewed Original ResearchConceptsSulfenic acidCell-permeable chemical probesSulfenic acid modificationCysteine sulfenic acid modificationTranscription factor Yap1Chemical probesCysteine oxidationRedox switchElectrostatic calculationsIntermolecular disulfide formationCharge distributionHydrogen peroxideAcid modificationNuclear accumulationIntermolecular disulfideConformational rearrangementsDisulfide formationCentral unresolved questionYAP1 activationYAP1GPX3Chemical dissectionCatalysisUnresolved questionsAcid
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