2020
Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines
Kellnerová S, Chatterjee S, Bayarri-Olmos R, Justesen L, Talasz H, Posch W, Kenno S, Garred P, Orth-Höller D, Grasse M, Würzner R. Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines. Toxins 2020, 13: 8. PMID: 33374102, PMCID: PMC7824702, DOI: 10.3390/toxins13010008.Peer-Reviewed Original ResearchMeSH KeywordsCell LineCell SurvivalComplement C3bComplement C5Gene Expression RegulationHumansProtein BindingShiga ToxinUp-RegulationConceptsCell linesHemolytic uremic syndromeRole of complementHK-2 cellsHuman target cell linesTarget cell linesMain virulent factorShiga toxin 2aEffective subtypeUremic syndromeReal-time PCRStx2aComplement component C3bShiga toxinWestern blotGene transcriptionComplement proteinsProtein synthesisVirulent factorsHuman cell linesComplement protein C3bInfectionC3bFurther investigationELISA
2015
Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway
Ma Y, Hein E, Munthe-Fog L, Skjoedt M, Bayarri-Olmos R, Romani L, Garred P. Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway. The Journal Of Immunology 2015, 195: 3365-3373. PMID: 26290605, DOI: 10.4049/jimmunol.1500493.Peer-Reviewed Original ResearchConceptsSoluble pattern recognition moleculesPattern recognition moleculesUmbilical cord plasmaVascular endothelial cellsTerminal complement complexCollectin-12Natural soluble formWestern blot analysisCord plasmaAlternative pathwaySoluble formInnate immunityComplement activationSoluble collectinsWestern blotComplement complexEndothelial cellsC3b depositionCL-12Blot analysisHuman umbilical cord plasmaElectrophoretic mobility patternsCollectin familyA. fumigatusNovel mechanism
2012
The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection
Wetzel DM, McMahon-Pratt D, Koleske AJ. The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection. Molecular And Cellular Biology 2012, 32: 3176-3186. PMID: 22665498, PMCID: PMC3434515, DOI: 10.1128/mcb.00086-12.Peer-Reviewed Original ResearchConceptsComplement receptor 3Leishmania infectionIgG-coated beadsMurine cutaneous leishmaniasisPotential therapeutic targetLeishmania uptakeVisceral diseaseObligate intracellular parasitesCutaneous leishmaniasisTherapeutic targetFc receptorsAmastigote uptakeTreatment resultsReceptor 3Small lesionsInfection severityLeishmania amazonensisKinase inhibitorsIntracellular parasitesBead phagocytosisPhagocytosisReceptorsC3biInfectionLeishmaniasis
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