Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines
Kellnerová S, Chatterjee S, Bayarri-Olmos R, Justesen L, Talasz H, Posch W, Kenno S, Garred P, Orth-Höller D, Grasse M, Würzner R. Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines. Toxins 2020, 13: 8. PMID: 33374102, PMCID: PMC7824702, DOI: 10.3390/toxins13010008.Peer-Reviewed Original ResearchConceptsCell linesHemolytic uremic syndromeRole of complementHK-2 cellsHuman target cell linesTarget cell linesMain virulent factorShiga toxin 2aEffective subtypeUremic syndromeReal-time PCRStx2aComplement component C3bShiga toxinWestern blotGene transcriptionComplement proteinsProtein synthesisVirulent factorsHuman cell linesComplement protein C3bInfectionC3bFurther investigationELISA
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply