Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5–dependent and –independent mechanisms
Treviño-Villarreal J, Reynolds J, Bartelt A, Langston P, MacArthur M, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace L, Mejia P, Trocha K, Kajitani G, Longchamp A, Harputlugil E, Gathungu R, Bird S, Bullock A, Figenshau R, Andriole G, Thompson A, Heeren J, Ozaki C, Kristal B, Fontana L, Mitchell J. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5–dependent and –independent mechanisms. JCI Insight 2018, 3: e99470. PMID: 30385734, PMCID: PMC6238732, DOI: 10.1172/jci.insight.99470.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoprotein A-VApolipoproteinsCyclic AMP Response Element-Binding ProteinDiet, Protein-RestrictedFemaleHumansHydrolysisHypertriglyceridemiaLipid MetabolismLipoproteins, VLDLLiverMaleMechanistic Target of Rapamycin Complex 1MiceProtein Serine-Threonine KinasesRandomized Controlled Trials as TopicRisk FactorsTriglyceridesConceptsAPOA5 expressionProtein restrictionTG-lowering effectVLDL-TGIntegrated stress responseFatty acid oxidation-related genesHepatic expressionVLDL triglyceride levelsIndependent risk factorRandomized controlled clinical trialVLDL-TG secretionVLDL-TG hydrolysisDietary protein restrictionDiet-induced obese miceOxidation-related genesVLDL particle numberStress responseExpression of fatty acid oxidation-related genesTriglyceride levelsDietary interventionClinical trialsPlasma triglyceridesAxis activityClinical relevanceObese mice
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